Results 61 to 70 of about 481 (138)

Palmitoylation‐Mediated Ubiquitination of SRPK1 Regulates Ferroptosis in High‐Fat‐Induced Erectile Dysfunction

Advanced Science, Volume 13, Issue 19, 2 April 2026.
Elevated exogenous palmitic acid promotes the S‐palmitoylation of SRPK1 in endothelial cells, a dynamic process governed by ZDHHC24 and APT1. This post‐translational modification strengthens the interaction between SRPK1 and the E3 ubiquitin ligase MIB1, thereby facilitating the proteasomal degradation of SRPK1.
Xiao‐Hui Tan, Ke‐Fan Li, Yi‐Ming Yuan, Man‐Cheng Xia, Fang‐Zhou Zhao, Hong‐Gang Ying, Zhuo Zhou, Peng‐Chao Gao, Guo‐Qing Xie, Xue‐Song Li, Hui Jiang, Rui‐Li Guan   +11 more
wiley   +1 more source

Regulation of dendritic morphology and synapse formation by the intellectual disability associated palmitoyl acyl transferases zDHHC15 and zDHHC9

, 2020
Palmitoylation is a reversible post-translational modification that facilitates vesicular transport and subcellular localization of modified proteins. This process is catalyzed by a family of palmitoyl acyltransferases known as zDHHC enzymes and mounting
Shimell, Jordan J.
core   +1 more source

Hemagglutinin of Influenza A, but not of Influenza B and C viruses is acylated by ZDHHC2, 8, 15 and 20

Hemagglutinin (HA), a glycoprotein of Influenza A viruses and its proton channel M2 are site-specifically modified with fatty acids. Whereas two cysteines in the short cytoplasmic tail of HA contain only palmitate, stearate is exclusively attached to one
Veit, Michael, Gadalla, Mohamed Rasheed, van der Goot, F. Gisou, Abrami, Laurence   +3 more
core   +1 more source

Post‐Translational Regulation of CD8+ T Cell Fate and Dysfunction in Tumor Immunity

Advanced Science, Volume 13, Issue 21, 13 April 2026.
This review delineates how post‐translational modifications (PTMs) function as a central regulatory interface governing CD8+ T cell activation, differentiation, persistence, and exhaustion in antitumor immunity. By integrating antigenic, metabolic, and microenvironmental cues, diverse PTM programs coordinate transcriptional and chromatin states that ...
Zihao Zhou, Xu Chen, Nina Li, Meiyan Zou, Yunfan Lin, Pei Lin, Weiyao Feng, Xinyuan Zhao, Li Cui   +8 more
wiley   +1 more source

Functional dissection of the zDHHC palmitoyltransferase 5–golgin A7 palmitoylation complex

Journal of Biological Chemistry
Small molecules serve as valuable tools for probing nonapoptotic cell death mechanisms. The small molecule caspase independent lethal 56 (CIL56) induces a unique form of nonapoptotic cancer cell death that is promoted by a complex formed between zDHHC palmitoyltransferase 5 (ZDHHC5) and an accessory protein, golgin A7 (GOLGA7, also known as GCP16). The
Martha A. Kahlson, Joan Ritho, João Victor Gomes, Haoqing Wang, Joel A. Butterwick, Scott J. Dixon   +5 more
openaire   +2 more sources

Zebrafish ZDHHC11 palmitoylates STING to potentiate antiviral immune response

Cell Communication and Signaling
In mammals, the activation of stimulator of interferon gene (STING), a pivotal adaptor protein mediating type I interferon (IFN-I) induction upon DNA virus infection, is regulated by palmitoylation.
Tingting Yu, Meifeng Li, Hongying Zhang, Jihuan Hu, Miaomiao Li, Quanling Zhang, Xuefeng Liu, Zhixin Fu, Chengyu Hu, Xiaowen Xu   +9 more
doaj   +1 more source

Role of S-acylating enzymes in ciliated cells

S-acylation is a post-translational modification that can regulate protein localization, function, and turnover by reversible attachment of fatty acid to specific cysteine residues.
Korotkova, Daria
core   +1 more source

DNA Methylation‐Regulated ZDHHC24 Exacerbates the Risk of Intracranial Aneurysms

Brain and Behavior, Volume 16, Issue 4, April 2026.
Multimodal Mendelian randomization integrating multi‐omics datasets pinpointed four DNA‐methylation loci that act in concert with the palmitoylation gene ZDHHC24 to modulate intracranial aneurysm risk, shedding new light on the molecular etiology of IA susceptibility and highlighting potential therapeutic targets.
Hao Yuan, Can Li, Xin Feng, Jiancheng Lin, Chi Huang, Mengshi Huang, Chuanzhi Duan   +6 more
wiley   +1 more source

Pharmacological Inhibition of APT2 by Solasonine Promotes Ferroptosis Through Palmitoylation Modulation in Gallbladder Cancer

Phytotherapy Research, Volume 40, Issue 4, Page 1642-1660, April 2026.
Schematic illustration of SS‐induced ferroptosis through targeting APT2‐mediated STAT3 palmitoylation in GBC cells. ABSTRACT Gallbladder cancer (GBC), the most prevalent and lethal biliary tract malignancy, lacks effective therapeutic strategies. Solasonine (SS), a bioactive steroidal alkaloid derived from Solanum nigrum L, exhibits antitumor activity ...
Liu‐qing Shi, Jing‐wei Zhao, Jia‐yun Zhu, Cheng Zhao, Zi‐yi Yang, Li‐jia Pan, Ben Ma, Zheng‐yu Chen, Zi‐ying Wang, Chun‐jie Li, Shi‐lei Liu, Jia‐wei Mei, Ping Dong   +12 more
wiley   +1 more source

Toward the identification of ZDHHC enzymes required for palmitoylation of viral protein as potential drug targets

Expert Opinion on Drug Discovery, 2019
Introduction: S-acylation is the attachment of fatty acids not only to cysteines of cellular, but also of viral proteins. The modification is often crucial for the protein´s function and hence for virus replication. Transfer of fatty acids is mediated by one or several of the 23 members of the ZDHHC family of proteins.
Gadalla, Mohamed Rasheed, Veit, Michael
openaire   +2 more sources