Results 41 to 50 of about 473 (132)

S-acylation and neuroinflammation: the therapeutic potential of zDHHC and deacylase modulation

European Journal of Medicinal Chemistry
Neuroinflammation is a hallmark of many neurodegenerative diseases, including Alzheimer's, Parkinson's and Huntington's disease, multiple sclerosis, and infantile neuronal ceroid lipofuscinosis. Dynamic protein S-acylation, a reversible lipid post-translational modification, is an important regulator in these processes.
Tiago A Duarte, Choa P. Ng, Jorge A. R. Salvador, Ludovico Pipitò, Jennifer Greaves, Vânia M. Moreira   +5 more
openalex   +3 more sources

A fluorescence-based assay to monitor autopalmitoylation of zDHHC proteins applicable to high-throughput screening [PDF]

Analytical Biochemistry, 2014
Palmitoylation, the posttranslational thioester-linked modification of a 16-carbon saturated fatty acid onto the cysteine residue of a protein, has garnered considerable attention due to its implication in a multitude of disease states. The signature DHHC motif (Asp-His-His-Cys) identifies a family of protein acyltransferases (PATs) that catalyze the S-
Laura D. Hamel, Robert J. Deschenes, David A. Mitchell   +2 more
openalex   +4 more sources

Molecular basis of fatty acid selectivity in the zDHHC family of S-acyltransferases revealed by click chemistry [PDF]

Proceedings of the National Academy of Sciences, 2017
Significance S-acylation, the attachment of different fatty acids onto cysteine residues, regulates the activity of a diverse array of cellular proteins. This reversible posttranslational modification is essential for normal physiology, and defects are linked to human disease.
Jennifer Greaves, Kevin R. Munro, Stuart C. Davidson, Matthieu Rivière, Justyna Wojno, Terry Smith, Nicholas C. O. Tomkinson, Luke Chamberlain   +7 more
openalex   +7 more sources

Bisphenol A (BPA) has transgenerational effects on the development of experimental asthma through BRD4/ZDHHC-1/STING axis [PDF]

Journal of Allergy and Clinical Immunology, 2023
Terumi Midoro‐Horiuti, Randall M. Goldblum, Kazuyo Kuzume, Kangling Zhang   +3 more
openalex   +2 more sources

Identification of ZDHHC enzymes catalyzing acylation of influenza virus Hemagglutinin

, 2020
Influenza viruses are negative sense segmented enveloped RNA viruses covered with 2 surface peplomers: the trimeric hemagglutinin (HA), which catalyzes virus entry by binding to sialic acid containing receptors and by performing fusion of viral with endosomal membranes and the neuraminidase (NA), which is required for release of virus particles from ...
Mohamed Rasheed Gadalla
openalex   +3 more sources

Construction and validation of prognostic risk model for hepatocellular carcinoma based on biological analysis of palmitoyl-associated enzyme long-chain non-coding RNA

Shanghai Jiaotong Daxue xuebao. Yixue ban, 2023
Objective·To explore the effect of screening the expression of long non-coding RNA (lncRNA) related to palmitoylation on prognosis of liver cancer based on The Cancer Genome Atlas (TCGA) database and construct a risk prediction model in liver cancer ...
YU Li, SU Xiandu, ZHANG Min, LI Yahui, WANG Le   +4 more
doaj   +1 more source

Cytoplasmic tail determines the membrane trafficking and localization of SARS-CoV-2 spike protein

Frontiers in Molecular Biosciences, 2022
The spike (S) glycoprotein of SARS-CoV-2 mediates viral entry through associating with ACE2 on host cells. Intracellular trafficking and palmitoylation of S protein are required for its function.
Qinlin Li, Qinlin Li, Qinlin Li, Yihan Liu, Yihan Liu, Leiliang Zhang, Leiliang Zhang, Leiliang Zhang   +7 more
doaj   +1 more source

ZDHHC16 restrains osteogenic differentiation of bone marrow mesenchymal stem cells by inhibiting phosphorylation of CREB

Heliyon, 2023
Aims: The osteogenesis of human bone marrow mesenchymal stem cells (hBMSCs) plays a critical role in fracture healing. Osteogenic differentiation is regulated by a variety of post-translational modifications, but the function of protein palmitoylation in
Zhiwei Li, Yuan Cheng, Xiangyun Jin, Feiyan Wang, Xinyi Wang, Shenghe Liu, Chao Zhang   +6 more
doaj   +1 more source

Functional dissection of the zDHHC palmitoyltransferase 5–golgin A7 palmitoylation complex

Journal of Biological Chemistry
Small molecules serve as valuable tools for probing nonapoptotic cell death mechanisms. The small molecule caspase independent lethal 56 (CIL56) induces a unique form of nonapoptotic cancer cell death that is promoted by a complex formed between zDHHC palmitoyltransferase 5 (ZDHHC5) and an accessory protein, golgin A7 (GOLGA7, also known as GCP16). The
Martha A. Kahlson, Joan Ritho, J. Gomes, Haoqing Wang, Joel A. Butterwick, Scott J. Dixon   +5 more
openalex   +3 more sources

STING Suppresses Mitochondrial VDAC2 to Govern RCC Growth Independent of Innate Immunity

Advanced Science, 2023
STING is an innate immune sensor for immune surveillance of viral/bacterial infection and maintenance of an immune‐friendly microenvironment to prevent tumorigenesis.
Zhichuan Zhu, Xin Zhou, Hongwei Du, Erica W. Cloer, Jiaming Zhang, Liu Mei, Ying Wang, Xianming Tan, Austin J. Hepperla, Jeremy M. Simon, Jeanette Gowen Cook, Michael B. Major, Gianpietro Dotti, Pengda Liu   +13 more
doaj   +1 more source