Results 41 to 50 of about 481 (138)

Additional file 1 of Palmitoyl transferases act as novel drug targets for pancreatic cancer

, 2023
Additional file 1: Fig. S1. Representative immunohistochemical images of ZDHHC family members in human pancreatic cancer tissue from the HPA database. Fig. S2.
Zhiqing Lin (496540), Keke Huang (15264535), Ziru Lv (15264532), Xin Liu (43569)   +3 more
core   +1 more source

Editorial: role of protein palmitoylation in synaptic plasticity and neuronal differentiation [PDF]

, 2020
© The Author(s), 2020. This article is distributed under the terms of the Creative Commons Attribution License. The definitive version was published in Yoshii, A., & Green, W. N.
Yoshii, Akira, Green, William N.
core   +1 more source

ZDHHC19 Is Dispensable for Spermatogenesis, but Is Essential for Sperm Functions in Mice

, 2021
Spermatogenesis is a complicated process involving mitotically proliferating spermatogonial cells, meiotically dividing spermatocytes, and spermatid going through maturation into spermatozoa.
Shuai Wang, Hongjie Qiao, Danian Qin, Yuan Wang, Pengxiang Wang   +4 more
core   +1 more source

Protein palmitoylation in bovine ovarian follicle

, 2021
International audienceProtein palmitoylation is a reversible post-translational modification by fatty acids (FA), mainly a palmitate (C16:0). Palmitoylation allows protein shuttling between the plasma membrane and cytosol to regulate protein stability ...
Jarrier-Gaillard, Peggy, Valerie Labas, Rustem Uzbekov, Pascal Papillier, Svetlana Uzbekova, Teixeira-Gomes, Ana-Paula, Shedova, Ekaterina, N., Uzbekova, Svetlana, Marestaing, Aurélie, Ana-Paula Teixeira-Gomes, Aurélie Marestaing, Singina, Galina, Peggy Jarrier-Gaillard, Papillier, Pascal, Labas, Valerie, Galina N. Singina, Uzbekov, Rustem, Ekaterina N. Shedova   +17 more
core   +1 more source

Molecular basis of fatty acid selectivity in the zDHHC family of S-acyltransferases revealed by click chemistry [PDF]

Proceedings of the National Academy of Sciences, 2017
Significance S-acylation, the attachment of different fatty acids onto cysteine residues, regulates the activity of a diverse array of cellular proteins. This reversible posttranslational modification is essential for normal physiology, and defects are linked to human disease.
Greaves, Jennifer, Munro, Kevin R., Davidson, Stuart C., Riviere, Matthieu, Wojno, Justyna, Smith, Terry K., Tomkinson, Nicholas C.O., Chamberlain, Luke H.   +7 more
openaire   +11 more sources

A fluorescence-based assay to monitor autopalmitoylation of zDHHC proteins applicable to high-throughput screening [PDF]

Analytical Biochemistry, 2014
Palmitoylation, the posttranslational thioester-linked modification of a 16-carbon saturated fatty acid onto the cysteine residue of a protein, has garnered considerable attention due to its implication in a multitude of disease states. The signature DHHC motif (Asp-His-His-Cys) identifies a family of protein acyltransferases (PATs) that catalyze the S-
Laura D, Hamel, Robert J, Deschenes, David A, Mitchell   +2 more
openaire   +2 more sources

The Growth Supporting Role of ZDHHC11 Is Linked to the MEF2B–BCL6 Regulatory Circuit in Burkitt Lymphoma

International Journal of Cancer, Volume 159, Issue 6, Page 1535-1545, 15 September 2026.
MEF2B and BCL6 have established functions in germinal center B‐cell biology and lymphomagenesis. The mechanism of MEF2B deregulation and its significance for cell survival in Burkitt lymphoma however remain unclear. This study highlights MEF2B as a crucial transcription factor in Burkitt lymphoma and suggests ZDHHC11 as an upstream regulator of MEF2B ...
Lotteke J. Y. M. Ziel‐Swier, Karolina Rassek, Yichen Liu, Annika Seitz, Jasper Koerts, Debora de Jong, Bea Rutgers, Anastasiia Kompaniiets, Julia Przybył, Martine E. D. Chamuleau, Anke van den Berg, Agnieszka Dzikiewicz‐Krawczyk, Joost Kluiver   +12 more
wiley   +1 more source

The Intrinsically Disordered Termini of zDHHC S-Palmitoyltransferases Facilitate Multiple Regulatory Functions [PDF]

Biophysical Journal, 2015
zDHHC protein acyltransferases (PATs) are a family of membrane proteins that catalyze the reversible post-translational lipidation known as palmitoylation, a process essential to normal cellular function through facilitation of membrane attachment, subcellular trafficking, and protein stability.
Krishna D., Reddy, Reddy, Krishna D., Baker, Jeremy D., Xue, Bin, Deschenes, Robert J., Uversky, Vladimir N.   +5 more
openaire   +2 more sources

ZDHHC17‐Mediated CDK4 Palmitoylation Drives Cell Cycle Progression and Orchestrates Cancer Immune Surveillance

Advanced Science, Volume 13, Issue 44, 7 August 2026.
ZDHHC17 palmitoylates CDK4, which together with TRAF6‐mediated ubiquitination, drives cell cycle progression and immune surveillance, revealing a rational combination of CDK4 inhibitors with immune checkpoint blockers for ZDHHC17‐driven cancers. ABSTRACT Uncontrolled cell cycle progression is a hallmark of cancer, tightly regulated by both intrinsic ...
Zekang Wang, Peipei Song, Xueji Wu, Lei Wang, Wei Xie, Pinning Feng, Chao Cheng, Jianping Guo   +7 more
wiley   +1 more source

ABHD17C‐Mediated S‐Depalmitoylation of BCL6B Enhances CD24 Transcription to Resist Macrophage Phagocytosis in Pancreatic Cancer

Advanced Science, Volume 13, Issue 45, 13 August 2026.
ABHD17C‐mediated depalmitoylation of BCL6B at Cys442 blocks its nuclear import and triggers ubiquitin‐dependent degradation, attenuating transcriptional repression of the anti‐phagocytic signal CD24. This mechanism enables pancreatic cancer cells to evade macrophage phagocytosis and fosters an immunosuppressive microenvironment.
Yalu Zhang, Di Cui, Fanzheng Meng, Xu Zhu, Liang Zhu, Liang Wu, Haifeng Hu, Jizhou Wang, Hanhui Yao, Lianxin Liu   +9 more
wiley   +1 more source