Results 11 to 20 of about 481 (138)

Protein S-Palmitoylation as Potential Therapeutic Target for Dermatoses [PDF]

Biomolecules
Protein S-palmitoylation is a pivotal yet poorly integrated research field in dermatology. This reversible post-translational lipid modification primarily occurs on cysteine residues and is principally catalyzed by zinc finger and Asp-His-His-Cys DHHC ...
Yanhai Feng, Jianxin Wu, Hui Tang, Shunying Liu, Honglin Jia, Yi Liang, Zhenglin Li, Lingbo Li, Lingfei Li, Xia Lei   +9 more
exaly   +4 more sources

A palmitoyl transferase chemical-genetic system to map ZDHHC-specific S-acylation [PDF]

Nat Biotechnol, 2023
The 23 human zinc finger Asp-His-His-Cys motif-containing (ZDHHC) S-acyltransferases catalyze long-chain S-acylation at cysteine residues across an extensive network of hundreds of proteins important for normal physiology or dysregulated in disease. Here
Ocasio, Cory A, Storck, Elisabeth M, Eggert, Ulrike S, Tavares, Manuel, Palma-Duran, Susana A, Sipthorp, James, Tate, Edward W, Tate, Edward W., Baggelaar, Marc P, Soudy, Christelle, Carr, Lotte, Eggert, Ulrike S., Volarić, Jana, Storck, Elisabeth M., MacRae, James I., Losada de la Lastra, Ana, MacRae, James I, Tomić, Goran, Palma-Duran, Susana A., Houghton, Jack W., Ocasio, Cory A., Baggelaar, Marc P., Houghton, Jack W, Downward, Julian   +23 more
core   +7 more sources

Recent advances in S-palmitoylation and its emerging roles in human diseases [PDF]

Journal of Hematology and Oncology
S-palmitoylation, one reversible post-translational modification (PTM) involving the binding of palmitate to proteins, influences protein stability, localization and interactions.
Xiangxiang Zhou, Juanjuan Shang
exaly   +3 more sources

zDHHC-Mediated S-Palmitoylation in Skin Health and Its Targeting as a Treatment Perspective [PDF]

Int J Mol Sci
S-acylation, which includes S-palmitoylation, is the only known reversible lipid-based post-translational protein modification. S-palmitoylation is mediated by palmitoyl acyltransferases (PATs), a family of 23 enzymes commonly referred to as zDHHCs ...
Brittany B. Rork, Andrew J. Maroun, Darya N. Shirzad, Harrison Tsai, Meera Nanjundan, Dea Fejzo, Evan C. Ratkus, Ashlynn E. Gilbert, Vincent L. Van Brunt, Farah A. Abdulrahman, Gregory T. Lin, Hugo Abasto Valle, Abdulrahman K. Shehadeh, Jafet E. Marquez, Zack Jones, Catherine A. McWee, Ethny Indico, Caleb Sammons, King A. Benford, Lexie F. Underwood   +19 more
core   +4 more sources

The emerging roles of ZDHHCs-mediated protein palmitoylation in the antiviral innate immune responses

Critical Reviews in Microbiology, 2021
Post-translational modifications (PTMs) play a pivotal role in expanding functional protein diversity. During viral infection, pathogen-associated molecular patterns derived from viruses are recognized by pattern recognition receptors present in the membrane surface and the cytoplasm of infected cells, which subsequently induces the antiviral innate ...
Chunfu Zheng
exaly   +4 more sources

The role of s-palmitoylation in neurological diseases: implication for zDHHC family. [PDF]

Front Pharmacol, 2023
S-palmitoylation is a reversible posttranslational modification, and the palmitoylation reaction in human-derived cells is mediated by the zDHHC family, which is composed of S-acyltransferase enzymes that possess the DHHC (Asp-His-His-Cys) structural domain.
Liao D, Huang Y, Liu D, Zhang H, Shi X, Li X, Luo P.   +6 more
europepmc   +4 more sources

siRNA Knockdown of Mammalian zDHHCs and Validation of mRNA Expression by RT-qPCR

Methods in Molecular Biology, 2019
The lack of specific pharmacological tools to interrogate the functional role of palmitoyl acyltransferases (zDHHCs) in mammalian cells has significantly hampered the understanding of this important gene family. Gene silencing by RNA interference (RNAi) is a process in eukaryotes that allows specific knockdown of the expression of proteins by targeting
Mike Shipston, Heather McClafferty
exaly   +4 more sources

ZDHHC18‐Mediated Palmitoylation of ORF3a Promotes SARS‐CoV‐2 Pathogenesis by Antagonizing TRIM16‐Mediated Ubiquitination and Proteasomal Degradation [PDF]

Advanced Science, Volume 13, Issue 43, 3 August 2026.
Palmitoylation by ZDHHC18 blocks ORF3a K27‐linked ubiquitination mediated by TRIM16, thereby preventing its proteasomal degradation and strengthening viral pathogenesis. Targeting palmitoylation through a pharmacological inhibitor (2‐BP), a competitive inhibitory peptide (OPIP), or adenovirus‐mediated knockdown of ZDHHC18 expression presents a ...
Sidi Yang, Kun Li, Lihong Liu, Linsen Zeng, Qifeng Deng, Jiacheng Huang, Xiaoran Dong, Xin Wang, Jianwei Liang, Hongchao Liu, Hong Peng, Yuxin Lin, Xiaolu Xie, Yuzhen Ye, Tiefeng Xu, Zhaohuan Wang, Chun‐Mei Li, Deyin Guo   +17 more
wiley   +2 more sources

Novel chemical genetic tools for the proteomic profiling of S-acylation by ZDHHC enzymes [PDF]

, 2023
Post-translational modifications (PTM) represent the largest source of proteome diversity, regulating the function and fate of almost every eukaryotic protein.
Losada De La Lastra, Ana
core   +3 more sources

Identifizierung von ZDHHC-Enzymen, die die Acylierung des Influenzavirus Hämagglutinin katalysieren

, 2020
Influenza viruses are negative sense segmented enveloped RNA viruses covered with 2 surface peplomers: the trimeric hemagglutinin (HA), which catalyzes virus entry by binding to sialic acid containing receptors and by performing fusion of viral with ...
Gadalla, Mohamed Rasheed Abdelalim Mohamed
core   +2 more sources