A facile assay for zDHHC palmitoyl transferase activation elucidates effects of mutation and modification [PDF]
Journal of Lipid ResearchAt least 10% of proteins constituting the human proteome are subject to S-acylation by a long-chain fatty acid, thioesterified to a Cys thiol side chain.
Naoko Adachi +2 more
exaly +8 more sources
Bioinformatics Analysis of the Prognostic and Biological Significance of ZDHHC-Protein Acyltransferases in Kidney Renal Clear Cell Carcinoma [PDF]
Frontiers in Oncology, 2020 ZDHHC-protein acyltransferases (ZDHHCs) are a family of 23 signature Asp-His-His-Cys (DHHC) domain-containing enzymes that mediate palmitoylation by covalent attachment of the 16-carbon fatty acid palmitate to thiol groups of specific cysteine residues ...
Zhuang Liu, Mingming Xiao, Yamei Han
exaly +6 more sources
Substrate recruitment by zDHHC protein acyltransferases [PDF]
Open Biology, 2021 Protein palmitoylation is the post-translational attachment of fatty acids, most commonly palmitate (C16 : 0), onto a cysteine residue of a protein. This reaction is catalysed by a family of integral membrane proteins, the zDHHC protein acyltransferases (
Martin Ian P. Malgapo, Maurine E. Linder
doaj +4 more sources
zDHHC-Mediated S-Palmitoylation in Skin Health and Its Targeting as a Treatment Perspective [PDF]
International Journal of Molecular SciencesS-acylation, which includes S-palmitoylation, is the only known reversible lipid-based post-translational protein modification. S-palmitoylation is mediated by palmitoyl acyltransferases (PATs), a family of 23 enzymes commonly referred to as zDHHCs, which catalyze the addition of palmitate to cysteine residues on specific target proteins.
Harrison Tsai, Nanjundan Meera
exaly +5 more sources
Diverse Roles of Protein Palmitoylation in Cancer Progression, Immunity, Stemness, and Beyond [PDF]
Cells, 2023 Protein S-palmitoylation, a type of post-translational modification, refers to the reversible process of attachment of a fatty acyl chain—a 16-carbon palmitate acid—to the specific cysteine residues on target proteins.
Mingli Li, Chun-Wei Chen, Li Mingli
exaly +4 more sources
A palmitoyl transferase chemical–genetic system to map ZDHHC-specific S-acylation [PDF]
Nature BiotechnologyAbstract The 23 human zinc finger Asp-His-His-Cys motif-containing (ZDHHC) S -acyltransferases catalyze long-chain S -acylation at cysteine residues across an extensive network of hundreds of proteins important for normal physiology or
Cory A Ocasio +2 more
exaly +7 more sources
Role of S-palmitoylation in digestive system diseases [PDF]
Cell Death DiscoveryDigestive system diseases, including liver diseases, gastrointestinal cancers, and inflammatory bowel diseases, pose major health challenges worldwide.
Qi Xing-Si Mm +2 more
exaly +3 more sources
The role of s-palmitoylation in neurological diseases: implication for zDHHC family. [PDF]
Front Pharmacol, 2023 S-palmitoylation is a reversible posttranslational modification, and the palmitoylation reaction in human-derived cells is mediated by the zDHHC family, which is composed of S-acyltransferase enzymes that possess the DHHC (Asp-His-His-Cys) structural domain.
Liao D +6 more
europepmc +6 more sources
Palmitoyl transferase zDHHCs: novel targets in Alzheimer’s disease [PDF]
Alzheimer's and Dementia, 2023 AbstractBackgroundGrowing evidence points to altered metabolic signals as a risk factor for Alzheimer’s disease (AD). The high fatty acid levels and brain insulin resistance (BIR) found in AD brains may impinge on protein S‐palmitoylation, which is a post‐translational modification critically involved in the regulation of neuronal protein localization ...
Salvatore Fusco, Claudio Grassi
exaly +3 more sources
Research progress on S-palmitoylation modification mediated by the ZDHHC family in glioblastoma. [PDF]
Front Cell Dev BiolS-Palmitoylation has been widely noticed and studied in a variety of diseases. Increasing evidence suggests that S-palmitoylation modification also plays a key role in Glioblastoma (GBM). The zDHHC family, as an important member of S-palmitoyltransferases, has received extensive attention for its function and mechanism in GBM which is one of the most ...
Tang B +7 more
europepmc +6 more sources