Results 51 to 60 of about 15,826,951 (219)
Discovery and Characterization of IFITM S-Palmitoylation
, 2023 Interferon-induced transmembrane proteins (IFITM1, 2 and 3) are important host antiviral defense factors. They are active against viruses like the influenza A virus (IAV), dengue virus (DENV), Ebola virus (EBOV), Zika virus (ZIKV) and severe acute ...
Tandrila Das, Howard C. Hang
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SwissPalm: Protein Palmitoylation database [v1; ref status: indexed, http://f1000r.es/5co]
F1000Research, 2015 Protein S-palmitoylation is a reversible post-translational modification that regulates many key biological processes, although the full extent and functions of protein S-palmitoylation remain largely unexplored.
Mathieu Blanc +6 more
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Steroid hormone rapid signaling: The pivotal role of S-Palmitoylation [PDF]
IUBMB Life, 2006 Nuclear receptors (NRs) comprise a large family of proteins essential to manipulate various aspects of human biology. The class III of the NR family includes steroid hormone receptors (SHRs) involved in embryonic development, maintenance of differentiated cellular phenotypes, metabolism, and cell death.
MARINO, Maria, ASCENZI, Paolo
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ZDHHC7-mediated S-palmitoylation of Scribble regulates cell polarity [PDF]
Nature Chemical Biology, 2016 Scribble (SCRIB) is a tumor-suppressor protein, playing critical roles in establishing and maintaining epithelial cell polarity. SCRIB is frequently amplified in human cancers but does not localize properly to cell-cell junctions, suggesting that mislocalization of SCRIB disrupts its tumor-suppressive activities.
Baoen Chen +6 more
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Frontiers in Immunology, 2022 The interferon-induced transmembrane protein 3 (IFITM3), a small molecule transmembrane protein induced by interferon, is generally conserved in vertebrates, which can inhibit infection by a diverse range of pathogenic viruses such as influenza virus ...
Shubo Wen +8 more
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Protein Lipidation by Palmitate Controls Macrophage Function
Cells, 2022 Macrophages are present in all tissues within our body, where they promote tissue homeostasis by responding to microenvironmental triggers, not only through clearance of pathogens and apoptotic cells but also via trophic, regulatory, and repair functions.
Jeroen Guns +3 more
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PLoS ONE, 2017 S-palmitoylation, the covalent attachment of 16-carbon palmitic acids to a cysteine residue via a thioester linkage, is an important reversible lipid modification that plays a regulatory role in a variety of physiological and biological processes. As the
Shun-Long Weng +3 more
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Palmitoylation-prone APP mutants exhibit increased APP dimerization compared to wtAPP.
, 2016 A. Schematic representation of the Cys to Ser mutants of APP used for the following co-immunoprecipitation assays. B. Co-immunoprecipitation assay in cells co-expressing APPV5 and HA-APPY and its mutants containing indicated Cys to Ser substitution.
Dora M. Kovacs (3359177) +4 more
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Palmitoylation and depalmitoylation defects [PDF]
, 2021 Palmitoylation describes the enzymatic attachment of a 16-carbon atom fatty acid to a target protein. Such lipidation events occur in all eukaryotes and can be of reversible (S-palmitoylation) or irreversible (N-palmitoylation) nature.
Hornemann, Thorsten
core
Frontiers in Molecular Neuroscience, 2021 Glutamate is the major excitatory neurotransmitter in the vertebrate brain and various modifications have been established in the glutamatergic synapses.
Takashi Hayashi
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