Results 31 to 40 of about 15,826,951 (219)
Akt Is S-Palmitoylated: A New Layer of Regulation for Akt [PDF]
Frontiers in Cell and Developmental Biology, 2021 The protein kinase Akt/PKB participates in a great variety of processes, including translation, cell proliferation and survival, as well as malignant transformation and viral infection. In the last few years, novel Akt posttranslational modifications have been found.
Matías Blaustein +23 more
openaire +5 more sources
Protein S -palmitoylation in immunity [PDF]
Open Biology, 2021 S -palmitoylation is a reversible posttranslational lipid modification of proteins. It controls protein activity, stability, trafficking and protein–protein interactions. Recent global profiling of immune cells and targeted analysis have identified many S -palmitoylated ...
Tandrila Das +2 more
openaire +3 more sources
PPT1 regulation of HSP90α depalmitoylation participates in the pathogenesis of hyperandrogenism
iScience, 2023 Summary: Ovarian granulosa cells (GCs) in the follicle are the important mediator of steroidogenesis and foster oocyte maturation. Evidences suggested that the function of GCs could be regulated by S-palmitoylation.
Tongmin Xue +13 more
doaj +1 more source
Palmitoylation-Dependent Small-Molecule Fluorescent Probes for Live-Cell Golgi Imaging
, 2023 Small-molecule fluorescent probes enabling visualization of the Golgi apparatus in living cells are essential tools for studying Golgi-associated biological processes and diseases.
Emi Mishiro-Sato (14426149) +13 more
core +3 more sources
S-palmitoylation and the regulation of NCX1 [PDF]
Channels, 2015 Investigations into reversible cysteine acylation (S-palmitoylation) have enjoyed a renaissance recently, thanks to numerous techniques that have improved the sensitivity of detection above the tra...
Fuller, William +2 more
openaire +3 more sources
S-Palmitoylation of Tyrosinase at Cysteine500 Regulates Melanogenesis
Journal of Investigative Dermatology, 2023 Palmitoylation is a lipid modification involving the attachment of palmitic acid to a cysteine residue, thereby affecting protein function. We investigated the effect of palmitoylation of tyrosinase, the rate-limiting enzyme in melanin synthesis, using a human three-dimensional skin model system and melanocyte culture.
Yoko Niki +14 more
openaire +2 more sources
Protein S-palmitoylation regulates different stages of meiosis in Schizosaccharomyces pombe
Life Science Alliance, 2023 The vital role of S-palmitoylation in cell differentiation is demonstrated in the fission yeast by showing that the modification is required at multiple meiotic stages including mating and karyogamy.
Thanh-Vy Pham +4 more
doaj +1 more source
S-Palmitoylation of Synaptic Proteins in Neuronal Plasticity in Normal and Pathological Brains
Cells, 2023 Protein lipidation is a common post-translational modification of proteins that plays an important role in human physiology and pathology. One form of protein lipidation, S-palmitoylation, involves the addition of a 16-carbon fatty acid (palmitate) onto ...
Anna Buszka +4 more
doaj +1 more source
eLife, 2022 Protein S-palmitoylation is a reversible post-translational lipid modification that plays a critical role in neuronal development and plasticity, while dysregulated S-palmitoylation underlies a number of severe neurological disorders.
Angela R Wild +7 more
doaj +1 more source
Topology-driven discovery of transmembrane protein S-palmitoylation. [PDF]
J Biol ChemProtein S-palmitoylation is a reversible lipophilic posttranslational modification regulating diverse signaling pathways. Within transmembrane proteins (TMPs), S-palmitoylation is implicated in conditions from inflammatory disorders to respiratory viral infections.
Forrester MT +5 more
europepmc +3 more sources