Results 11 to 20 of about 21,089,371 (171)

Protein S-palmitoylation in cellular differentiation [PDF]

Biochemical Society Transactions, 2017
Reversible protein S-palmitoylation confers spatiotemporal control of protein function by modulating protein stability, trafficking and activity, as well as protein–protein and membrane–protein associations.
Mingzi M. Zhang, Howard C. Hang
core   +3 more sources

S-palmitoylation of MAP kinase is essential for fungal virulence

mBio
S-palmitoylation is an important reversible protein post-translational modification in organisms. However, its role in fungi is uncertain. Here, we found the treatment of the rice false fungus Ustilaginoidea virens with S-palmitoylation inhibitor 2 BP ...
Yuhang Duan, Pingping Li, Deyao Zhang, Lili Wang, Yuan Fang, Hong Hu, Qiulu Mao, Xiaolan Zhou, Panpan Zhao, Xuechun Li, Jinfeng Wei, Jintian Tang, Li Pan, Hao Liu, Xiaolin Chen, Xiaoyang Chen, Tom Hsiang, Junbin Huang, Lu Zheng   +18 more
doaj   +3 more sources

Protein S-Palmitoylation as Potential Therapeutic Target for Dermatoses

Biomolecules
Protein S-palmitoylation is a pivotal yet poorly integrated research field in dermatology. This reversible post-translational lipid modification primarily occurs on cysteine residues and is principally catalyzed by zinc finger and Asp-His-His-Cys DHHC ...
Yanhai Feng, Jianxin Wu, Hui Tang, Shunying Liu, Honglin Jia, Yi Liang, Zhenglin Li, Lingbo Li, Lingfei Li, Xia Lei   +9 more
doaj   +4 more sources

Role of S-palmitoylation in digestive system diseases

Cell Death Discovery
Digestive system diseases, including liver diseases, gastrointestinal cancers, and inflammatory bowel diseases, pose major health challenges worldwide.
Hanqing Li, Qiuxiang Yuan, Shuangshuang Wang, Tao Yu, Xingsi Qi   +4 more
doaj   +3 more sources

Protein S-palmitoylation modification: implications in tumor and tumor immune microenvironment [PDF]

Frontiers in Immunology
Protein S-palmitoylation is a reversible post-translational lipid modification that involves the addition of a 16-carbon palmitoyl group to a protein cysteine residue via a thioester linkage.
Yijiao Chen, Yongsheng Li, Lei Wu
doaj   +2 more sources

Advances in targeting protein S-palmitoylation in tumor immunity and therapy

Frontiers in Oncology
S-palmitoylation is a reversible and dynamic post-translational modification of proteins. A palmitoyl group is covalently attached to a cysteine residue of the protein by a thioester link.
Miaomiao Han, Miaomiao Han, Yuanhao Lv, Yuanhao Lv, Yiyang Chen, Zhaoyi Li, Jiaqi Tian, Hongyan Zhou, Yunlong Wang, Wei Su, Wei Su, Jiateng Zhong, Jiateng Zhong, Jiateng Zhong   +13 more
doaj   +3 more sources

Function of Protein S-Palmitoylation in Immunity and Immune-Related Diseases [PDF]

Frontiers in Immunology, 2021
Protein S-palmitoylation is a covalent and reversible lipid modification that specifically targets cysteine residues within many eukaryotic proteins. In mammalian cells, the ubiquitous palmitoyltransferases (PATs) and serine hydrolases, including acyl ...
Yuqi Zhang, Ziran Qin, Wenhuan Sun, Feng Chu, Fangfang Zhou   +4 more
doaj   +3 more sources

Targeted degradation of zDHHC-PATs decreases substrate S -palmitoylation [PDF]

PLOS ONE
Reversible S-palmitoylation of protein cysteines, catalysed by a family of integral membrane zDHHC-motif containing palmitoyl acyl transferases (zDHHC-PATs), controls the localisation, activity, and interactions of numerous integral and peripheral ...
Wilson, Sam J., Brown, Elaine, Shattock, Michael J., Swingler, Simon, Bai, Mingjie, GAO, Xing, Memarzadeh, Sarah, Fuller, William, France, David J., Howie, Jacqueline, Gallen, Emily, Kuo, Chien-Wen S.   +11 more
core   +4 more sources

Temporal Profiling Establishes a Dynamic S‑Palmitoylation Cycle

, 2018
S-palmitoylation is required for membrane anchoring, proper trafficking, and the normal function of hundreds of integral and peripheral membrane proteins.
Brent R. Martin (163859), Sang Joon Won (3280350)   +1 more
core   +7 more sources

S-palmitoylation-related genes in Crohn's disease: Bioinformatic identification and validation

Biomolecules & Biomedicine
Crohn's disease (CD) is a complex chronic inflammatory bowel disorder characterized by the absence of reliable biomarkers and effective targeted treatments.
Yuyan Zhou, Yuxuan Zhao
doaj   +3 more sources