Role of S-palmitoylation in digestive system diseases [PDF]
Cell Death DiscoveryDigestive system diseases, including liver diseases, gastrointestinal cancers, and inflammatory bowel diseases, pose major health challenges worldwide.
Hanqing Li +4 more
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Role of S-palmitoylation on IFITM5 for the interaction with FKBP11 in osteoblast cells. [PDF]
PLoS ONE, 2013 Recently, one of the interferon-induced transmembrane (IFITM) family proteins, IFITM3, has become an important target for the activity against influenza A (H1N1) virus infection.
Takashi Tsukamoto +6 more
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Protein S-palmitoylation modification: implications in tumor and tumor immune microenvironment [PDF]
Frontiers in ImmunologyProtein S-palmitoylation is a reversible post-translational lipid modification that involves the addition of a 16-carbon palmitoyl group to a protein cysteine residue via a thioester linkage.
Yijiao Chen, Yongsheng Li, Lei Wu
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Protein S-palmitoylation in cellular differentiation [PDF]
Biochemical Society Transactions, 2017 Reversible protein S-palmitoylation confers spatiotemporal control of protein function by modulating protein stability, trafficking and activity, as well as protein–protein and membrane–protein associations. Enabled by technological advances, global studies revealed S-palmitoylation to be an important and pervasive posttranslational modification in ...
Zhang, Mingzi M., Hang, Howard C.
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Inhibiting S-palmitoylation arrests metastasis by relocating Rap2b from plasma membrane in colorectal cancer [PDF]
Cell Death and DiseaseRap2b, a proto-oncogene upregulated in colorectal cancer (CRC), undergoes protein S-palmitoylation at specific C-terminus sites (C176/C177). These palmitoylation sites are crucial for Rap2b localization on the plasma membrane (PM), as mutation of C176 or
Jiangli Zhu +15 more
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PRDX6: A protein bridging S-palmitoylation and diabetic neuropathy
Frontiers in Endocrinology, 2022 Diabetic neuropathy is regarded as one of the most debilitating outcomes of diabetes. It can affect both the peripheral and central nervous systems, leading to pain, decreased motility, cognitive decline, and dementia.
Yan Cao +3 more
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The Roles of Protein S-Palmitoylation in Cancers: From Dynamic Modulation to Therapeutic Potential [PDF]
Cancer CommunicationsProtein S-palmitoylation is a highly conserved posttranslational lipid modification that occurs on cysteine residues and critically influences protein maturation, subcellular localization, trafficking, and stability. Owing to its unique reversibility and
Haonan Zheng +7 more
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S-palmitoylation-related genes in Crohn's disease: Bioinformatic identification and validation [PDF]
Biomolecules & BiomedicineCrohn's disease (CD) is a complex chronic inflammatory bowel disorder characterized by the absence of reliable biomarkers and effective targeted treatments.
Yuyan Zhou, Yuxuan Zhao
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Protein palmitoylation in cancer: molecular functions and therapeutic potential
Molecular Oncology, 2023 Protein S‐palmitoylation (hereinafter referred to as protein palmitoylation) is a reversible lipid posttranslational modification catalyzed by the zinc finger DHHC‐type containing (ZDHHC) protein family.
Binhui Zhou +2 more
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Diverse Roles of Protein Palmitoylation in Cancer Progression, Immunity, Stemness, and Beyond
Cells, 2023 Protein S-palmitoylation, a type of post-translational modification, refers to the reversible process of attachment of a fatty acyl chain—a 16-carbon palmitate acid—to the specific cysteine residues on target proteins.
Mingli Li, Chun-Wei Chen, Li Mingli
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