Results 1 to 10 of about 2,794 (185)

PIK3CA Mutations Downregulate PPT1 to Promote Adipogenesis by Suppressing P300 Depalmitoylation and Phase Separation [PDF]

Advanced Science
PIK3CA mutations drive benign adipose overgrowth in facial infiltrating lipomatosis (FIL), but the downstream molecular mechanisms remain incompletely understood.
Hongrui Chen, Zening Huang, Rui Chang, Wei Gao, Yajing Qiu, Bin Sun, Chen Hua, Xiaoxi Lin   +7 more
doaj   +5 more sources

S-palmitoylation and depalmitoylation at the interface of animal virus-host interactions [PDF]

Frontiers in Cellular and Infection Microbiology
Reversible protein S-palmitoylation, mediated by protein acyl transferases (PATs) and depalmitoylases, is essential for regulating numerous biological processes, including subcellular localization, protein stability, enzymatic activity, and protein ...
Rui-Qin Xu, Rui-Qin Xu, Xi-Meng Chen, Chen-Rong Wang, Shi-Jie Ma, Shi-Jie Ma, Shi-Jie Ma, Ping-Li Wang, Ping-Li Wang, Ping-Li Wang, Hong-Ying Chen, Hong-Ying Chen, Hong-Ying Chen   +12 more
doaj   +4 more sources

The role of lysosomal depalmitoylation in Alzheimer's Disease in vitro and in vivo models [PDF]

Alzheimer's &Dementia, Volume 21, Issue S1, December 2025.
Abstract Background Amyloidogenic proteins are palmitoylated, and changes in palmitoylation may affect Aβ plaques in AD (Alzheimer's Disease). Palmitoylation enriches amyloidogenic proteins in lipid rafts, while deficiency retains them in the endoplasmic reticulum, inhibiting Aβ accumulation.
Skarleth Cardenas Romero, Mei‐Yu Lai, Matthew J Rosene, Natalia López Herrera, Abraham Lopez, Gabriel Pagan Gonzalez, Adeeb Ahmad, James Patton, Christina Muratore, Bruno A. Benitez   +9 more
wiley   +3 more sources

Depalmitoylation by Palmitoyl-Protein Thioesterase 1 in Neuronal Health and Degeneration [PDF]

Frontiers in Synaptic Neuroscience, 2019
Protein palmitoylation is the post-translational, reversible addition of a 16-carbon fatty acid, palmitate, to proteins. Protein palmitoylation has recently garnered much attention, as it robustly modifies the localization and function of canonical ...
Kevin P. Koster, Akira Yoshii, Akira Yoshii, Akira Yoshii   +3 more
doaj   +3 more sources

Targeting MC1R depalmitoylation to prevent melanomagenesis in redheads [PDF]

Nature Communications, 2019
Melanocortin-1 receptor is a palmitoylated protein and variants of the receptor are associated with red hair colour and susceptibility to melanoma. Here, the authors describe a method to enhance the palmitoylation of the receptor, which can inhibit ...
Shuyang Chen, Changpeng Han, Xiao Miao, Xin Li, Chengqian Yin, Junrong Zou, Min Liu, Shanshan Li, Lukasz Stawski, Bo Zhu, Qiong Shi, Zhi-Xiang Xu, Chunying Li, Colin R. Goding, Jun Zhou, Rutao Cui   +15 more
doaj   +4 more sources

PPT1 regulation of HSP90α depalmitoylation participates in the pathogenesis of hyperandrogenism

iScience, 2023
Summary: Ovarian granulosa cells (GCs) in the follicle are the important mediator of steroidogenesis and foster oocyte maturation. Evidences suggested that the function of GCs could be regulated by S-palmitoylation.
Tongmin Xue, Shanmeizi Zhao, Hong Zhang, Ting Tang, Lu Zheng, Jun Jing, Xie Ge, Rujun Ma, Jinzhao Ma, Xiaoyan Ren, Kadiliya Jueraitetibaike, Zhigang Guo, Li Chen, Bing Yao   +13 more
doaj   +3 more sources

Palmitoylation of TBK1 enhances the type I interferon signaling and strengthens anti-malarial immunity in mice [PDF]

Nature Communications
Precise regulation of type I interferon signaling is crucial for effective immune defense against infectious diseases. However, the molecular mechanisms governing this pathway are not fully understood.
Zhongxin Han, Siyi Xiong, Ke Zeng, Zilong Xiao, Liying Zhang, Yufen Zhang, Jiaying Guo, Wenqiang Peng, Yingchao Xie, Weiwei Liu, Xiao Yu   +10 more
doaj   +2 more sources

Active and dynamic mitochondrial S-depalmitoylation revealed by targeted fluorescent probes [PDF]

Nature Communications, 2018
S-palmitoylation regulation has been studied mostly in the cytosol and its role in mitochondria is unclear. Here the authors develop fluorescent mitochondria-targeted probes and find that depalmitoylation occurs in mitochondria and it’s influenced by ...
Rahul S. Kathayat, Yang Cao, Pablo D. Elvira, Patrick A. Sandoz, María-Eugenia Zaballa, Maya Z. Springer, Lauren E. Drake, Kay F. Macleod, F. Gisou van der Goot, Bryan C. Dickinson   +9 more
doaj   +3 more sources

Pharmacological Inhibition of APT2 by Solasonine Promotes Ferroptosis Through Palmitoylation Modulation in Gallbladder Cancer [PDF]

Phytotherapy Research, Volume 40, Issue 4, Page 1642-1660, April 2026.
Schematic illustration of SS‐induced ferroptosis through targeting APT2‐mediated STAT3 palmitoylation in GBC cells. ABSTRACT Gallbladder cancer (GBC), the most prevalent and lethal biliary tract malignancy, lacks effective therapeutic strategies. Solasonine (SS), a bioactive steroidal alkaloid derived from Solanum nigrum L, exhibits antitumor activity ...
Liu‐qing Shi, Jing‐wei Zhao, Jia‐yun Zhu, Cheng Zhao, Zi‐yi Yang, Li‐jia Pan, Ben Ma, Zheng‐yu Chen, Zi‐ying Wang, Chun‐jie Li, Shi‐lei Liu, Jia‐wei Mei, Ping Dong   +12 more
wiley   +2 more sources

MC1R depalmitoylation inhibition reveals a physiological role for pheomelanin [PDF]

PNAS Nexus
Abstract Pheomelanin is a sulfur-containing pigment produced by melanocytes notably in individuals with red hair/fair skin and animals with orange integumentary structures. Pheomelanin is not photoprotective as the dark eumelanin, but is cytotoxic, being related to a high risk of melanoma independently of UV radiation.
Ismael Galván, Marina García-Guerra, Marta Araujo-Roque   +2 more
openaire   +3 more sources