Results 21 to 30 of about 2,071 (166)
Depalmitoylation regulates metabolism and mitochondrial function [PDF]
Tens of millions of Americans suffer from metabolic disorders, predisposing patients to cardiovascular disease, kidney disease, liver disease, infertility, and cancer.
Speck, Sarah Lilly
core +2 more sources
Palmitoylation: an emerging therapeutic target bridging physiology and disease [PDF]
Cellular & Molecular Biology LettersPalmitoylation is a reversible post-translational lipid modification of proteins, catalyzed by the Zinc finger DHHC domain-containing (ZDHHC) family of palmitoyltransferases.
Weini Li +7 more
doaj +2 more sources
Depalmitoylation of CAAX Motif Proteins [PDF]
Journal of Biological Chemistry, 1995 Jui-Yun Lu, Sandra L. Hofmann
core +2 more sources
Protein S-Palmitoylation as Potential Therapeutic Target for Dermatoses [PDF]
BiomoleculesProtein S-palmitoylation is a pivotal yet poorly integrated research field in dermatology. This reversible post-translational lipid modification primarily occurs on cysteine residues and is principally catalyzed by zinc finger and Asp-His-His-Cys DHHC ...
Yanhai Feng +9 more
doaj +2 more sources
Engineered depalmitoylases enable selective manipulation of protein localization and function [PDF]
Nature CommunicationsS-Palmitoylation is a reversible post-translational modification that tunes the localization, stability, and function of an impressive array of proteins including ion channels, G-proteins, and synaptic proteins.
Srinidhi Jayaraman +4 more
doaj +2 more sources
The Unconventional Role of ABHD17A in Increasing the S-Palmitoylation and Antiviral Activity of IFITM1 by Downregulating ABHD16A [PDF]
BiomoleculesThe broad-spectrum antiviral functions of interferon-inducible transmembrane 1 (IFITM1) rely on S-palmitoylation post-translational modification.
Xuemeng Shi +11 more
doaj +2 more sources
Protein Lipidation by Palmitoylation and Myristoylation in Cancer
Frontiers in Cell and Developmental Biology, 2021 Posttranslational modification of proteins with lipid moieties is known as protein lipidation. The attachment of a lipid molecule to proteins endows distinct properties, which affect their hydrophobicity, structural stability, localization, trafficking ...
Chee Wai Fhu, Azhar Ali
doaj +1 more source
Cln5 represents a new type of cysteine-based S -depalmitoylase linked to neurodegeneration [PDF]
, 2022 Genetic CLN5 variants are associated with childhood neurodegeneration and Alzheimer’s disease; however, the molecular function of ceroid lipofuscinosis neuronal protein 5 (Cln5) is unknown.
Becker, Stefan +10 more
core +6 more sources
Hepatology, EarlyView., 2022 KAT7‐acetylated and cytoplasm‐translocated G‐protein GαS enhances IL‐6 effect and drives HCC progenitor cell progression. Abstract Background and Aims Hepatocarcinogenesis goes through HCC progenitor cells (HcPCs) to fully established HCC, and the mechanisms driving the development of HcPCs are still largely unknown.
Ye Zhou +15 more
wiley +1 more source
Frontiers in Physiology, 2022 S-palmitoylation is an essential lipid modification catalysed by zDHHC-palmitoyl acyltransferases that regulates the localisation and activity of substrates in every class of protein and tissue investigated to date.
Alice Main +11 more
doaj +1 more source