PIK3CA Mutations Downregulate PPT1 to Promote Adipogenesis by Suppressing P300 Depalmitoylation and Phase Separation [PDF]
Advanced SciencePIK3CA mutations drive benign adipose overgrowth in facial infiltrating lipomatosis (FIL), but the downstream molecular mechanisms remain incompletely understood.
Hongrui Chen +7 more
doaj +5 more sources
Glutathione-dependent depalmitoylation of phospholemman by peroxiredoxin 6 [PDF]
Cell ReportsSummary: Phospholemman (PLM) regulates the cardiac sodium pump: PLM phosphorylation activates the pump whereas PLM palmitoylation inhibits its activity.
Jacqueline Howie +11 more
doaj +5 more sources
Targeting MC1R depalmitoylation to prevent melanomagenesis in redheads [PDF]
Nature Communications, 2019 Melanocortin-1 receptor is a palmitoylated protein and variants of the receptor are associated with red hair colour and susceptibility to melanoma. Here, the authors describe a method to enhance the palmitoylation of the receptor, which can inhibit ...
Shuyang Chen +15 more
doaj +6 more sources
ABHD7-mediated depalmitoylation of lamin A promotes myoblast differentiation
Cell ReportsSummary: LMNA gene mutation can cause muscular dystrophy, and post-translational modification plays a critical role in regulating its function. Here, we identify that lamin A is palmitoylated at cysteine 522, 588, and 591 residues, which are reversely ...
Yuan Shen +10 more
doaj +4 more sources
Active and dynamic mitochondrial S-depalmitoylation revealed by targeted fluorescent probes [PDF]
Nature Communications, 2018 S-palmitoylation regulation has been studied mostly in the cytosol and its role in mitochondria is unclear. Here the authors develop fluorescent mitochondria-targeted probes and find that depalmitoylation occurs in mitochondria and it’s influenced by ...
Rahul S. Kathayat +9 more
doaj +6 more sources
Pathogens, 2022 Dynamic post-translational modifications allow the rapid, specific, and tunable regulation of protein functions in eukaryotic cells. S-acylation is the only reversible lipid modification of proteins, in which a fatty acid, usually palmitate, is ...
Robert W. B. Brown +15 more
doaj +2 more sources
Role of Palmitoylation of Postsynaptic Proteins in Promoting Synaptic Plasticity [PDF]
Frontiers in Molecular Neuroscience, 2019 Many postsynaptic proteins undergo palmitoylation, the reversible attachment of the fatty acid palmitate to cysteine residues, which influences trafficking, localization, and protein interaction dynamics.
Lucas Matt +3 more
doaj +2 more sources
[28] Depalmitoylation of rhodopsin with hydroxylamine
Methods in enzymology, 1995 Intrinsic membrane proteins that to date have been investigated with respect to the function of palmitoylation are the beta-adrenergic receptor, rhodopsin, the alpha 2A-adrenergic receptor, and the influenza virus spike glycoprotein. As described above, the studies have led to differing conclusions with respect to the influence of palmitoylation on ...
David R. Pepperberg +2 more
core +3 more sources
Enzymatic Depalmitoylation of Viral Glycoproteins with Acyl-Protein Thioesterase 1 in Vitro [PDF]
Virology, 2001 Many glycoproteins of enveloped viruses as well as cellular proteins are covalently modified with fatty acids. Palmitoylation is often reversible, but the enzymology of this hydrophobic protein modification is not understood.
Veit, Michael, Schmidt, Michael F.G.
core +3 more sources
Developmental NMDA receptor dysregulation in the infantile neuronal ceroid lipofuscinosis mouse model [PDF]
eLife, 2019 Protein palmitoylation and depalmitoylation alter protein function. This post-translational modification is critical for synaptic transmission and plasticity.
Kevin P Koster +5 more
doaj +2 more sources