Restoration of Osimertinib sensitivity in lung cancer through BRD4 inhibitor-mediated depalmitoylation of mutant EGFR via APT1 [PDF]
npj Precision OncologyNon-small cell lung cancer (NSCLC) with epidermal growth factor receptor (EGFR) mutations initially responds to the third-generation EGFR-tyrosine kinase inhibitor (TKI) Osimertinib.
Wolong Zhou +6 more
doaj +2 more sources
Influence of palmitoylation in axonal transport mechanisms in neurodegenerative diseases [PDF]
Frontiers in Cellular NeuroscienceProgressive functional loss and death of neurons are characteristics of neurodegenerative diseases such as Alzheimer’s disease (AD), Amyotrophic lateral sclerosis (ALS), and Parkinson’s disease (PD).
Praveen B. S., Priti Talwar
doaj +2 more sources
Depalmitoylase ABHD16A negatively regulates the anti-hepatitis B virus activity of IFITM1 [PDF]
Microbiology SpectrumInterferon-inducible transmembrane (IFITM) proteins have been widely reported as antiviral factors against various viral pathogens. However, the mechanisms of IFITM regulation on hepatitis B virus (HBV), which induces chronic infection resulting in ...
Xin Wen +8 more
doaj +2 more sources
Glutathione-dependent depalmitoylation of phospholemman by peroxiredoxin 6
Cell ReportsSummary: Phospholemman (PLM) regulates the cardiac sodium pump: PLM phosphorylation activates the pump whereas PLM palmitoylation inhibits its activity.
Jacqueline Howie +11 more
doaj +4 more sources
The Roles of Protein S-Palmitoylation in Cancers: From Dynamic Modulation to Therapeutic Potential [PDF]
Cancer CommunicationsProtein S-palmitoylation is a highly conserved posttranslational lipid modification that occurs on cysteine residues and critically influences protein maturation, subcellular localization, trafficking, and stability. Owing to its unique reversibility and
Haonan Zheng +7 more
doaj +2 more sources
Inhibition of BRD4 sensitizes NSCLC cells to osimertinib by suppressing APT1 and promoting MST1 palmitoylation [PDF]
Cell Death DiscoveryOsimertinib is widely used to treat non-small-cell lung cancer (NSCLC) carrying epidermal growth factor receptor (EGFR) mutations. However, osimertinib resistance inevitably develops in almost all patients.
Shaoqiang Wang +5 more
doaj +2 more sources
S-palmitoylation modulates ATG2-dependent non-vesicular lipid transport during starvation-induced autophagy [PDF]
The EMBO JournalLipid transfer proteins mediate the non-vesicular transport of lipids at membrane contact sites to regulate the lipid composition of organelle membranes. Despite significant recent advances in our understanding of the structural basis for lipid transfer,
Wenhui Zheng +9 more
doaj +2 more sources
ABHD7-mediated depalmitoylation of lamin A promotes myoblast differentiation
Cell ReportsSummary: LMNA gene mutation can cause muscular dystrophy, and post-translational modification plays a critical role in regulating its function. Here, we identify that lamin A is palmitoylated at cysteine 522, 588, and 591 residues, which are reversely ...
Yuan Shen +10 more
doaj +3 more sources
Palmitoylation: an emerging therapeutic target bridging physiology and disease [PDF]
Cellular & Molecular Biology LettersPalmitoylation is a reversible post-translational lipid modification of proteins, catalyzed by the Zinc finger DHHC domain-containing (ZDHHC) family of palmitoyltransferases.
Weini Li +7 more
doaj +2 more sources
CD36 and Its Role in Obesity [PDF]
Obesity Reviews, Volume 27, Issue 3, March 2026.ABSTRACT Obesity is understood as a condition driven by interactions between genetics and environmental factors. The role of CD36 in the regulation of lipid metabolism and ectopic fat accumulation emerges as a key area of interest. This review presents CD36 not only as a crucial facilitator of fatty acid uptake but also as a regulator of how and where ...
Nahuel Garcia +5 more
wiley +2 more sources