eLife, 2015 Dynamic changes in protein S-palmitoylation are critical for regulating protein localization and signaling. Only two enzymes - the acyl-protein thioesterases APT1 and APT2 – are known to catalyze palmitate removal from cytosolic cysteine residues.
David Tse Shen Lin, Elizabeth Conibear
doaj +1 more source
FKBP12 Binds to Acylated H-Ras and Promotes Depalmitoylation [PDF]
Molecular Cell, 2011 A cycle of palmitoylation/depalmitoylation of H-Ras mediates bidirectional trafficking between the Golgi apparatus and the plasma membrane, but nothing is known about how this cycle is regulated. We show that the prolyl isomerase (PI) FKBP12 binds to H-Ras in a palmitoylation-dependent fashion and promotes depalmitoylation.
Ahearn, Ian M. +8 more
openaire +2 more sources
Understanding the rules governing NCX1 palmitoylation [PDF]
, 2017 No abstract ...
Blanc M +4 more
core +3 more sources
Role of Palmitoylation of Postsynaptic Proteins in Promoting Synaptic Plasticity
Frontiers in Molecular Neuroscience, 2019 Many postsynaptic proteins undergo palmitoylation, the reversible attachment of the fatty acid palmitate to cysteine residues, which influences trafficking, localization, and protein interaction dynamics.
Lucas Matt +3 more
doaj +1 more source
Depalmitoylation of Ykt6 Prevents its Entry into the Multivesicular Body Pathway [PDF]
Traffic, 2008 The dually lipidated SNARE Ykt6 is found on intracellular membranes and in the cytosol. In this study, we show that Ykt6 localizes to the Golgi as well as endosomal and vacuolar membranes in vivo. The ability of Ykt6 to cycle between the cytosol and the membranes depends on the intramolecular interaction of the N‐terminal longin and C‐terminal SNARE ...
Christoph T A, Meiringer +3 more
openaire +2 more sources
Identification of novel post-transcriptional features in olfactory receptor family mRNAs. [PDF]
, 2015 Olfactory receptor (Olfr) genes comprise the largest gene family in mice. Despite their importance in olfaction, how most Olfr mRNAs are regulated remains unexplored.
Espinoza, Josh L +3 more
core +1 more source
Greasing the wheels or a spanner in the works?:Regulation of the cardiac sodium pump by palmitoylation [PDF]
, 2018 The ubiquitous sodium/potassium ATPase (Na pump) is the most abundant primary active transporter at the cell surface of multiple cell types, including ventricular myocytes in the heart.
Fiona Plain +10 more
core +3 more sources
Primary fibroblasts from CSPα mutation carriers recapitulate hallmarks of the adult onset neuronal ceroid lipofuscinosis [PDF]
, 2017 Mutations in the co- chaperone protein, CSPα, cause an autosomal dominant, adult-neuronal ceroid lipofuscinosis (AD-ANCL). The current understanding of CSPα function exclusively at the synapse fails to explain the autophagy-lysosome pathway (ALP ...
Benitez, Bruno A, Sands, Mark S
core +2 more sources
A fluorescent probe for cysteine depalmitoylation reveals dynamic APT signaling [PDF]
Nature Chemical Biology, 2016 Hundreds of human proteins are modified by reversible palmitoylation of cysteine residues (S-palmitoylation), but the regulation of depalmitoylation is poorly understood. Here, we develop 'depalmitoylation probes' (DPPs), small-molecule fluorophores, to monitor the endogenous activity levels of 'erasers' of S-palmitoylation, acylprotein thioesterases ...
Kathayat, Rahul S. +2 more
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Depalmitoylation rewires FLT3-ITD signaling and exacerbates leukemia progression
Blood, 2021 Abstract Internal tandem duplication within FLT3 (FLT3-ITD) is one of the most frequent mutations in acute myeloid leukemia (AML) and correlates with a poor prognosis. Whereas the FLT3 receptor tyrosine kinase is activated at the plasma membrane to transduce PI3K/AKT and RAS/MAPK signaling, FLT3-ITD resides in the endoplasmic ...
Kaosheng Lv +5 more
openaire +3 more sources