Results 41 to 50 of about 2,071 (166)
ABHD17 regulation of plasma membrane palmitoylation and N-Ras-dependent cancer growth [PDF]
, 2021 Multiple Ras proteins, including N-Ras, depend on a palmitoylation/depalmitoylation cycle to regulate their subcellular trafficking and oncogenicity.
Remsberg, Jarrett R +17 more
core +1 more source
Regulator of Ras Depalmitoylation and Retrograde Trafficking: A New Hat for FKBP [PDF]
Molecular Cell, 2011 In this issue of Molecular Cell, Ahearn et al. (2011) identified FKBP12 as a novel regulator of Ras signaling through its modulation of depalmitoylation of H-Ras and its recycling from plasma membrane to the Golgi.
Liu, Jun O. +3 more
openaire +2 more sources
Prediction of depalmitoylation kinetics.
, 2016 A: WT calnexin was labelled with 3H-palmitate in silico either for two hrs or to reach the steady state distribution of palmitoylation species. B: The kinetics of palmitate loss starting from the two distributions in A were determined.
Tiziano Dallavilla (2273956) +5 more
core +1 more source
In vitro depalmitoylation assay v1
, 2023 This protocol describes the in vitro depalmitoylation assay of DNAJC5
openaire +1 more source
Peroxiredoxin 6 mediates Gαi protein-coupled receptor inactivation by cJun kinase
Nature Communications, 2017 Opioid receptors are important modulators of nociceptive pain. Here the authors show that opioid receptor activation recruits peroxiredoxin 6 (PRDX6) to the receptor-Gαi complex by c-Jun N-terminal kinase, resulting in Gαi depalmitoylation and enhanced ...
Selena S. Schattauer +8 more
doaj +1 more source
Regenerative Therapy, 2023 Objective: Senile osteoporosis (SOP) is an aging-related disease. The depalmitoylating enzyme Acyl-protein thiesterase1 (APT1) is involved in disease regulation. This study explored the mechanism of APT1 in SOP.
Changjiao Ji +6 more
doaj +1 more source
Metabolic Labeling of Ras with Tritiated Palmitate to Monitor Palmitoylation and Depalmitoylation [PDF]
, 2013 Metabolic labeling with tritiated palmitate is a direct method for monitoring posttranslational modification of Ras proteins with this fatty acid. Advances in intensifying screens have allowed for the easy visualization of tritium without the need for extended exposure times.
Frederick D, Tsai +3 more
openaire +2 more sources
Depalmitoylated Ras traffics to and from the Golgi complex via a nonvesicular pathway [PDF]
The Journal of Cell Biology, 2005 Palmitoylation is postulated to regulate Ras signaling by modulating its intracellular trafficking and membrane microenvironment. The mechanisms by which palmitoylation contributes to these events are poorly understood. Here, we show that dynamic turnover of palmitate regulates the intracellular trafficking of HRas and NRas to and from the Golgi ...
Goodwin, J. Shawn +6 more
openaire +2 more sources
Mass Spectrometry Insights Into Post‐Translational Modifications in Extracellular Vesicles
Mass Spectrometry Reviews, EarlyView.ABSTRACT Extracellular vesicles (EVs) are membrane‐enclosed structures secreted by virtually all living cells, serving as essential mediators of intercellular communication in both physiological and pathological processes. There is growing interest in their potential applications as biomarkers, therapeutic targets, and drug delivery systems, which ...
Dávid Virág +5 more
wiley +1 more source
Protein palmitoylation in cancer: molecular functions and therapeutic potential
Molecular Oncology, 2023 Protein S‐palmitoylation (hereinafter referred to as protein palmitoylation) is a reversible lipid posttranslational modification catalyzed by the zinc finger DHHC‐type containing (ZDHHC) protein family.
Binhui Zhou +3 more
doaj +1 more source