MicroRNA Profiling and Bioinformatics Target Analysis in Dorsal Hippocampus of Chronically Stressed Rats: Relevance to Depression Pathophysiology [PDF]
, 2018 Indexación: Scopus.1Laboratory of Neuroplasticity and Neurogenetics, Faculty of Chemical and Pharmaceutical Sciences, Department of Biochemistry and Molecular Biology, Universidad de Chile, Santiago, Chile, 2National Institute of Environmental Health ...
Aguayo, F.I. +12 more
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eLife, 2019 Protein palmitoylation and depalmitoylation alter protein function. This post-translational modification is critical for synaptic transmission and plasticity.
Kevin P Koster +5 more
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Palmitoylation of the β4-Subunit Regulates Surface Expression of Large Conductance Calcium-activated Potassium Channel Splice Variants [PDF]
, 2013 Regulatory β-subunits of large conductance calcium- and voltage-activated potassium (BK) channels play an important role in generating functional diversity and control of cell surface expression of the pore forming α-subunits.
Bi, Danlei +7 more
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Individual Palmitoyl Residues Serve Distinct Roles in H-ras Trafficking, Microlocalization, and Signaling [PDF]
, 2005 H-ras is anchored to the plasma membrane by two palmitoylated cysteine residues, Cys181 and Cys184, operating in concert with a C-terminal S-farnesyl cysteine carboxymethylester. Here we demonstrate that the two palmitates serve distinct biological roles.
Roy, Sandrine +9 more
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In vitro depalmitoylation assay v1
, 2023 This protocol describes the in vitro depalmitoylation assay of DNAJC5
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Regulator of Ras Depalmitoylation and Retrograde Trafficking: A New Hat for FKBP [PDF]
Molecular Cell, 2011 In this issue of Molecular Cell, Ahearn et al. (2011) identified FKBP12 as a novel regulator of Ras signaling through its modulation of depalmitoylation of H-Ras and its recycling from plasma membrane to the Golgi.
Liu, Jun O. +3 more
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Cellular signaling and NO production [PDF]
, 2010 The endothelium can evoke relaxations (dilatations) of the underlying vascular smooth muscle, by releasing vasodilator substances. The best characterized endothelium-derived relaxing factor is nitric oxide (NO), which is synthesized by the endothelial ...
Michel, T, Vanhoutte, PM
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The physiology of protein S-acylation [PDF]
, 2015 Protein S-acylation, the only fully reversible posttranslational lipid modification of proteins, is emerging as a ubiquitous mechanism to control the properties and function of a diverse array of proteins and consequently physiological processes.
Chamberlain, Luke H. +1 more
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Protein Depalmitoylation Is Induced by Wnt5a and Promotes Polarized Cell Behavior [PDF]
Journal of Biological Chemistry, 2015 Wnt5a signaling regulates polarized cell behavior, but the downstream signaling events that promote cell polarity are not well understood. Our results show that Wnt5a promotes depalmitoylation of the melanoma cell adhesion molecule (MCAM) at cysteine 590.
Wei, Wang +4 more
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S-acylation of the insulin-responsive aminopeptidase (IRAP) : quantitative analysis and identification of modified cysteines [PDF]
, 2015 The insulin-responsive aminopeptidase (IRAP) was recently identified as an S-acylated protein in adipocytes and other tissues. However, there is currently no information on the extent of S-acylation of this protein, the residues that are modified, or the
Chamberlain, Luke H., Werno, Martin W.
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