Results 71 to 80 of about 2,071 (166)
S-palmitoylation: A novel player in cancer and its emerging therapeutic implications
Cell InvestigationS-palmitoylation is a reversible post-translational lipid modification involving the covalent attachment of palmitic acid to cysteine residues, thereby regulating protein localization, stability, trafficking, and function.
Ruiheng Wang +11 more
doaj +1 more source
Palmitoylation in Alzheimer’s disease and other neurodegenerative diseases [PDF]
, 2016 Posttranslational modifications of proteins are important regulatory processes endowing the proteins functional complexity. Over the last decade, numerous studies have shed light on the roles of palmitoylation, one of the most common lipid modifications,
Park, Mikyoung, Cho, Eunsil
core +1 more source
, 2021 Gene expression in neutrophils associated with the gene ontologies, (A) protein DP, and (B) glycolytic process. The underlying data can be found from the SRA portal of NCBI under accession number PRJNA674035.
Deanna M. Santer (8787614) +7 more
core +1 more source
Obesity Reviews, Volume 27, Issue 3, March 2026.ABSTRACT Obesity is understood as a condition driven by interactions between genetics and environmental factors. The role of CD36 in the regulation of lipid metabolism and ectopic fat accumulation emerges as a key area of interest. This review presents CD36 not only as a crucial facilitator of fatty acid uptake but also as a regulator of how and where ...
Nahuel Garcia +5 more
wiley +1 more source
Protein Science, Volume 35, Issue 2, February 2026.Abstract Palmitoylation is a reversible post‐translational modification that enhances protein hydrophobicity and regulates cellular functions such as trafficking and signaling. In humans, this modification is catalyzed by 23 DHHC enzymes, but the mechanisms by which they recognize their substrates remain unclear.
Dina A. Abdulrahman, Michael Veit
wiley +1 more source
Advanced Science, Volume 13, Issue 1, 5 January 2026.Our study reveals a novel mechanism by which palmitoylation regulates ferroptosis and enzalutamide resistance in prostate cancer. Under enzalutamide resistance, the FOXA1/CXXC5/TET2 complex induces aberrant upregulation of ZDHHC2, which subsequently suppresses ferroptosis by mediating S‐palmitoylation of USP19 and degradation of ACSL4 protein in CRPC ...
Shuai Shao +10 more
wiley +1 more source
Enhancing Gpx1 palmitoylation to inhibit angiogenesis by targeting PPT1
Redox BiologyThe significance of protein S-palmitoylation in angiogenesis has been largely overlooked, leaving various aspects unexplored. Recent identification of Gpx1 as a palmitoylated protein has generated interest in exploring its potential involvement in novel ...
Yidan Ma +9 more
doaj +1 more source
Reversible Binding and Trafficking of DNA Origami Between Lipid Membrane Phases
Small Structures, Volume 7, Issue 1, January 2026.A DNA origami nanostructure was functionalized with different lipophilic anchor types. Depending on the anchor type, these nanodevices selectively bind to a certain lipid phase with distinctive rigidities. Using the strand displacement method, these functionalized DNA origami nanostructures go through dimerization/monomerization steps, thereby ...
Rayehe Mamaghaniyeh, Henri G. Franquelim
wiley +1 more source
Search For The Functions That Mediate Protein Palmitoylation And Depalmitoylation
, 2010 Protein palmitoylation is a critical regulator of protein location, function and activity in the cell. While it has been known for some time that proteins can have cycles of palmitoylation and depalmitoylation throughout their lifetime, a thioesterase ...
Prior, Margaret
core +1 more source
Journal of VirologyInterferon-inducible transmembrane (IFITM) proteins are broad-spectrum antiviral factors that confer cellular resistance to virus invasion. α/β-Hydrolase domain-containing 16A (ABHD16A) has recently been identified as a novel depalmitoylase that can ...
Xuemeng Shi +10 more
doaj +1 more source