Results 91 to 100 of about 2,794 (185)

Role of the transmembrane domain in severe acute respiratory syndrome (SARS) coronavirus 2 spike for palmitoylation and membrane fusion

Protein Science, Volume 35, Issue 2, February 2026.
Abstract Palmitoylation is a reversible post‐translational modification that enhances protein hydrophobicity and regulates cellular functions such as trafficking and signaling. In humans, this modification is catalyzed by 23 DHHC enzymes, but the mechanisms by which they recognize their substrates remain unclear.
Dina A. Abdulrahman, Michael Veit
wiley   +1 more source

Attenuated palmitoylation of serotonin receptor 5-HT1A affects receptor function and contributes to depression-like behaviors [PDF]

, 2019
The serotonergic system and in particular serotonin 1A receptor (5-HT1AR) are implicated in major depressive disorder (MDD). Here we demonstrated that 5-HT1AR is palmitoylated in human and rodent brains, and identified ZDHHC21 as a major palmitoyl ...
Bazovkina, Daria, Bijata, Monika, Galil, Dalia Abdel, Gorinski, Nataliya, Kondaurova, Elena, Kulikova, Elizabeth [u.v.m.], Prasad, Sonal, Sigrist, Stephan, Wirth, Alexander, Zeug, Andre   +9 more
core   +1 more source

The Interactome of Palmitoyl-Protein Thioesterase 1 (PPT1) Affects Neuronal Morphology and Function

Frontiers in Cellular Neuroscience, 2019
Palmitoyl-protein thioesterase 1 (PPT1) is a depalmitoylation enzyme that is mutated in cases of neuronal ceroid lipofuscinosis (NCL). The hallmarks of the disease include progressive neurodegeneration and blindness, as well as seizures.
Tamar Sapir, Michal Segal, Gayane Grigoryan, Karin M. Hansson, Peter James, Peter James, Menahem Segal, Orly Reiner   +7 more
doaj   +1 more source

ZDHHC2‐Dependent Palmitoylation Dictates Ferroptosis and Castration Sensitivity in Prostate Cancer via Controlling ACSL4 Degradation and Lipid Peroxidation

Advanced Science, Volume 13, Issue 1, 5 January 2026.
Our study reveals a novel mechanism by which palmitoylation regulates ferroptosis and enzalutamide resistance in prostate cancer. Under enzalutamide resistance, the FOXA1/CXXC5/TET2 complex induces aberrant upregulation of ZDHHC2, which subsequently suppresses ferroptosis by mediating S‐palmitoylation of USP19 and degradation of ACSL4 protein in CRPC ...
Shuai Shao, Wei Li, Yulong Hong, Ruijiang Zeng, Liang Zhu, Lu Yi, Yuan Li, Yinhuai Wang, Haojie Huang, Xuewen Jiang, Xin Jin   +10 more
wiley   +1 more source

Glutamate receptor subunit 2 serine 880 phosphorylation modulates synaptic transmission and mediates plasticity in CA1 pyramidal cells [PDF]

, 2003
The cytoplasmic C termini of AMPA receptor subunits contain PDZ ( postsynaptic density 95/Discs large/zona occludens 1) ligand domains that can control their synaptic trafficking during plasticity.
Huganir, R., Malinow, R., Seidenman, K. J., Steinberg, J. P.   +3 more
core   +1 more source

Reversible Binding and Trafficking of DNA Origami Between Lipid Membrane Phases

Small Structures, Volume 7, Issue 1, January 2026.
A DNA origami nanostructure was functionalized with different lipophilic anchor types. Depending on the anchor type, these nanodevices selectively bind to a certain lipid phase with distinctive rigidities. Using the strand displacement method, these functionalized DNA origami nanostructures go through dimerization/monomerization steps, thereby ...
Rayehe Mamaghaniyeh, Henri G. Franquelim
wiley   +1 more source

Dynamic Arginine Methylation of YBX1 Relay Controls Its Phase Separation and Chemoradiotherapy Resistance in Rectal Cancer

Advanced Science, Volume 12, Issue 46, December 11, 2025.
Protein arginine methyltransferase 3 (PRMT3) induces the arginine methylation of Y‐box binding protein 1 (YBX1), which suppresses phase separation and is imperative for its nuclear translocation. Subsequently, lysine‐specific demethylase 4A demethylates YBX1 to unmask the R247 residue and promote its phase separation, which transcriptionally regulates ...
Yunxing Shi, Taixuan Wan, Shaoru Liu, Huashan Liu, Ziwei Zeng, Wenxin Li, Zhenxing Liang, Li Xiong, Shuanglin Luo, Yunfei Yuan, Liang Huang, Liang Kang   +11 more
wiley   +1 more source

The Ins and Outs of miRNA-Mediated Gene Silencing during Neuronal Synaptic Plasticity [PDF]

, 2016
Neuronal connections through specialized junctions, known as synapses, create circuits that underlie brain function. Synaptic plasticity, i.e., structural and functional changes to synapses, occurs in response to neuronal activity and is a critical ...
Hanley, Jonathan, Rajgor, Dipen
core   +3 more sources

miR-9 and miR-124 synergistically affect regulation of dendritic branching via the AKT/GSK3β pathway by targeting Rap2a [PDF]

, 2016
A single microRNA (miRNA) can regulate expression of multiple proteins, and expression of an individual protein may be controlled by numerous miRNAs.
Bian, G, Fang, C, Ju, G, Liu, F, Liu, L, Song, B, Wang, J, Wang, Y, Xue, Q, Yang, A, Yu, C, Zhang, K   +11 more
core   +1 more source

S-palmitoylation: A novel player in cancer and its emerging therapeutic implications

Cell Investigation
S-palmitoylation is a reversible post-translational lipid modification involving the covalent attachment of palmitic acid to cysteine residues, thereby regulating protein localization, stability, trafficking, and function.
Ruiheng Wang, Aojia Zhuang, Yifan Wu, Jie Shen, Yanan Zhang, Peipei Liu, Anas Rabata, Nedumaran Pavithra, Shaopeng Yu, Jiangling Peng, Yaxun Huang, Duoyao Cao   +11 more
doaj   +1 more source