Results 91 to 100 of about 2,071 (166)

Anti-regulation of palmitoyl anchors and PIP2 lipids.

, 2020
(A) A snapshot presenting the separated state of CD44-Pal-Dual and the FERM domain. CD44 is locked on the phase boundary with the palmitoyl anchors orientating to the raft domain.
Carlos R. Palacios (8694648), Lida Xu (326852), Carsten F. E. Schroer (7429250), Fude Sun (1577581), Siewert J. Marrink (135518), Shi-Zhong Luo (620108)   +5 more
core   +1 more source

Investigation of the properties of Acyl protein thioesterases and their role in Ras depalmitoylation

, 2017
Es konnte gezeigt werden, dass die Inhibition des Proteins Acyl Protein Thioesterase (APT) die Lokalisierung von palmitoylierten Ras Proteinen derart verändern kann, dass eine Reduzierung der onkogenen Ras Aktivität beobachtet wird. Die genaue physiologische Rolle von APT ist allerdings weiterhin unklar, da sowohl weitere palmitoylierte Proteine, als ...
openaire   +3 more sources

Functional Characterization of Serine Hydrolases Mediating Lipid Metabolism and Protein Depalmitoylation in Asexual Stage Plasmodium Falciparum

, 2023
Malaria is an infectious disease caused by Plasmodium parasites and transferred by Anopheles mosquitos. Due to Artemisinin resistance, new druggable targets identification and new drug development are urgently needed.
Liu, Jiapeng
core  

GABAAR-PPT1 palmitoylation homeostasis controls synaptic transmission and circuitry oscillation

Translational Psychiatry
The infantile neuronal ceroid lipofuscinosis, also called CLN1 disease, is a fatal neurodegenerative disease caused by mutations in the CLN1 gene encoding palmitoyl protein thioesterase 1 (PPT1).
Jia Tong, Jingjing Gao, Yawei Qi, Ziyan Gao, Qianqian Wang, Yang Liu, Tiangang Yuan, Minglong Ren, Guixia Yang, Zhaoyue Li, Jin Li, Hongyuan Sun, Xing Zhao, Yeung-Yeung Leung, Yonghui Mu, Jiamin Xu, Chengbiao Lu, Shiyong Peng, Lihao Ge   +18 more
doaj   +1 more source

Palmitoylation-dependent modulation of CD36 trafficking and signaling integrates lipid uptake with metabolic disease pathogenesis

Pharmacological Research
CD36 is a multifunctional lipid transporter that facilitates long-chain fatty acid uptake and orchestrates metabolic signaling in energy-demanding tissues.
Mingxun Li, Haoran Jia, Lei Zhang, Peng Chen, Shimeng Wang, Yongjiang Mao, Zhangping Yang   +6 more
doaj   +1 more source

Small-molecule inhibition of APT1 affects Ras localization and signaling

, 2010
Cycles of depalmitoylation and repalmitoylation critically control the steady-state localization and function of various peripheral membrane proteins, such as Ras proto-oncogene products. Interference with acylation using small molecules is a strategy to
Daniel Rauh, Hedberg, C., Renner, S., Menninger, S, Brunsveld, Luc, Balamurugan, Rengarajan, Dekker, Frank J., Wetzel, Stefan, Rauh, D, Balamurugan, R, Hedberg, Christian, Bastiaens, P.I.H., Vartak, N, Philippe I H Bastiaens, Gerauer, Marc, Balamurugan, Rangarajan, Schölermann, Beate, Kramer, J.W., Renner, Steffen, Waldmann, H., Coates, G., Bastiaens, PIH, Coates, G.W., Dekker, Frank J.; id_orcid, Schoelermann, Beate, Sascha Menninger, Kramer, JW, Gerauer, M., Steffen Renner, Schölermann, B, Menninger, Sascha, Rauh, Daniel, Coates, Geoffrey W, Luc Brunsveld, Rusch, M., Renner, S, John W Kramer, Nachiket Vartak, Vartak, Nachiket, Menninger, S., Wetzel, S, Dekker, F., Waldmann, Herbert, Balamurugan, R., Frank J Dekker, Rauh, D., Beate Schölermann, Rocks, Oliver, Herbert Waldmann, Bastiaens, P., Marc Gerauer, Rusch, Marion, Rocks, O., Rusch, M, Hedberg, C, Wetzel, S., Dekker, F.J., Oliver Rocks, Geoffrey W Coates, Stefan Wetzel, Dekker, FJ, Bastiaens, P.I., Rengarajan Balamurugan, Brunsveld, L Luc, Bastiaens, Philippe I. H., Christian Hedberg, Gerauer, M, Coates, Geoffrey W., Rocks, O, Brunsveld, L., Kramer, J., Schölermann, B., Kramer, John W., Schoelermann, B., Vartak, N., Marion Rusch, Brunsveld, L.; id_orcid   +76 more
core   +1 more source

Nanobody-thioesterase chimeras to specifically target protein palmitoylation

Nature Communications
The complexity of the cellular proteome is massively expanded by a repertoire of chemically distinct reversible post-translational modifications (PTMs) that control protein localisation, interactions, and function.
Chien-Wen Kuo, Caglar Gök, Hannah Fulton, Eleanor Dickson-Murray, Samuel Adu, Emily K. Gallen, Sheon Mary, Alan D. Robertson, Fiona Jordan, Emma Dunning, William Mullen, Godfrey L. Smith, William Fuller   +12 more
doaj   +1 more source

Mechanistic Insights into S‑Depalmitolyse Activity of Cln5 Protein Linked to Neurodegeneration and Batten Disease: A QM/MM Study

Ceroid lipofuscinosis neuronal protein 5 (Cln5) is encoded by the CLN5 gene. The genetic variants of this gene are associated with the CLN5 form of Batten disease. Recently, the first crystal structure of Cln5 was reported.
Yuvraj Dangat (1495096), Marek Freindorf (1433188), Elfi Kraka (1433197)   +2 more
core   +2 more sources

Cyclical palmitoylation regulates TLR9 signalling and systemic autoimmunity in mice

Nature Communications
Toll-like receptor 9 (TLR9) recognizes self-DNA and plays intricate roles in systemic lupus erythematosus (SLE). However, the molecular mechanism regulating the endosomal TLR9 response is incompletely understood.
Hai Ni, Yinuo Wang, Kai Yao, Ling Wang, Jiancheng Huang, Yongfang Xiao, Hongyao Chen, Bo Liu, Cliff Y. Yang, Jijun Zhao   +9 more
doaj   +1 more source

Editorial: Role of protein palmitoylation in synaptic plasticity and neuronal differentiation, volume II

Frontiers in Synaptic Neuroscience
Kevin P. Koster, William N. Green
doaj   +1 more source