Results 111 to 120 of about 2,794 (185)
eLife, 2018 Wnt5a has been implicated in melanoma progression and metastasis, although the exact downstream signaling events that contribute to melanoma metastasis are poorly understood.
Rochelle Shirin Sadeghi +6 more
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Measuring S-Depalmitoylation Activity In Vitro and In Live Cells with Fluorescent Probes [PDF]
, 2019 S-palmitoylation is a reversible lipid posttranslational modification (PTM) that can mediate protein localization, trafficking, interaction with membranes, and a host of other biophysical characteristics. Over the past decade, a suite of chemoproteomic strategies have uncovered the breadth of S-palmitoylation, revealing widespread susceptibility to ...
Rahul S, Kathayat, Bryan C, Dickinson
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Quantitative analysis of the human T cell palmitome [PDF]
, 2015 Palmitoylation is a reversible post-translational modification used to inducibly compartmentalize proteins in cellular membranes, affecting the function of receptors and intracellular signaling proteins.
Brügger, Britta +5 more
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Developmental and Activity-Dependent miRNA Expression Profiling in Primary Hippocampal Neuron Cultures [PDF]
, 2013 MicroRNAs (miRNAs) are evolutionarily conserved non-coding RNAs of ∼22 nucleotides that regulate gene expression at the level of translation and play vital roles in hippocampal neuron development, function and plasticity.
Akhmanova, A.S. (Anna) +10 more
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Genome-wide dissection of microRNA functions and cotargeting networks using gene-set signatures [PDF]
, 2010 MicroRNAs are emerging as important regulators of diverse biological processes and pathologies in animals and plants. Though hundreds of human microRNAs are known, only a few have known functions.
Alexander van Oudenaarden +81 more
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MicroRNAs in the pathophysiology and treatment of status epilepticus [PDF]
, 2013 MicroRNA (miRNA) are an important class of non-coding RNA which function as post-transcriptional regulators of gene expression in cells, repressing and fine-tuning protein output.
Henshall, David C
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Depalmitoylation of CAAX Motif Proteins [PDF]
Journal of Biological Chemistry, 1995 Jui-Yun Lu, Sandra L. Hofmann
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An outlook on protein S-acylation in plants:what are the next steps? [PDF]
, 2017 S-acylation, also known as palmitoylation, is the reversible post-translational addition of fatty acids to proteins. Historically thought primarily to be a means for anchoring otherwise soluble proteins to membranes, evidence now suggests that reversible
Hemsley, Piers A.
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NCLs and ER: A stressful relationship. [PDF]
, 2017 The Neuronal Ceroid Lipofuscinoses (NCLs, Batten disease) are a group of inherited neurodegenerative disorders with variable age of onset, characterized by the lysosomal accumulation of autofluorescent ceroid lipopigments.
Marotta, D, Mole, SE, Tinelli, E
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Neurobiology of DiseaseLysosomal storage disorders (LSDs) represent 70 inherited metabolic diseases, in most of which neurodegeneration is a devastating manifestation. The CLN1 disease is a fatal neurodegenerative LSD, caused by inactivating mutations in the CLN1 gene encoding
Nisha Plavelil +5 more
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