Results 121 to 130 of about 2,794 (185)

Analysis and validation of novel biomarkers related to palmitoylation in adenomyosis

Frontiers in Genetics
BackgroundAdenomyosis, a common gynecological disorder in women of reproductive age, is characterized by endometrial invasion into the myometrium, leading to uterine enlargement and smooth muscle hypertrophy.
Hongyu Zhang, Yufeng Li, Huijuan Cao, Yiling Zhao, Hongwen Zhu, Tiansheng Qin   +5 more
doaj   +1 more source

APT1-derived depalmitoylation of CD36 alleviates diabetes-induced lipotoxicity in podocytes

International Journal of Biological Sciences
Cluster of Differentiation 36 (CD36), also known as scavenger receptor B2, plays a critical role in controlling podocyte lipid metabolism, mediating the onset and progression of diabetic kidney disease (DKD). However, the post-translational regulation of CD36 and its exact role in lipid transport within podocytes remain unclear.
Wang, Juan, Hu, Jijia, Hu, Hongtu, Guan, Qian, Zhu, Zijing, Yang, Qian, Ding, Guohua   +6 more
openaire   +2 more sources

Spatial regulation of the acylation cycle by thioesterase auto-depalmitoylation

, 2015
The acylation cycle is a reaction diffusion mechanism thatmaintains H/N-Ras localization on the plasma membrane (PM)by countering the equilibration of palmitoylated H/N-Rasproteins to endomembranes. The thioesterases APT1/2perform this critical function of depalmitoylating mislocalizedH/N-Ras proteins, thereby allowing them to diffuse rapidly andre ...
Vartak, Nachiket, Papke, Bjoern, Christian Hedberg, Rossmanek, Lisaweta   +3 more
openaire   +1 more source

Palmitoylation as a Functional Regulator of Neurotransmitter Receptors

Neural Plasticity, 2018
The majority of neuronal proteins involved in cellular signaling undergo different posttranslational modifications significantly affecting their functions.
Vladimir S. Naumenko, Evgeni Ponimaskin
doaj   +1 more source

Investigation of the properties of Acyl protein thioesterases and their role in Ras depalmitoylation

, 2017
Es konnte gezeigt werden, dass die Inhibition des Proteins Acyl Protein Thioesterase (APT) die Lokalisierung von palmitoylierten Ras Proteinen derart verändern kann, dass eine Reduzierung der onkogenen Ras Aktivität beobachtet wird. Die genaue physiologische Rolle von APT ist allerdings weiterhin unklar, da sowohl weitere palmitoylierte Proteine, als ...
openaire   +3 more sources

GABAAR-PPT1 palmitoylation homeostasis controls synaptic transmission and circuitry oscillation

Translational Psychiatry
The infantile neuronal ceroid lipofuscinosis, also called CLN1 disease, is a fatal neurodegenerative disease caused by mutations in the CLN1 gene encoding palmitoyl protein thioesterase 1 (PPT1).
Jia Tong, Jingjing Gao, Yawei Qi, Ziyan Gao, Qianqian Wang, Yang Liu, Tiangang Yuan, Minglong Ren, Guixia Yang, Zhaoyue Li, Jin Li, Hongyuan Sun, Xing Zhao, Yeung-Yeung Leung, Yonghui Mu, Jiamin Xu, Chengbiao Lu, Shiyong Peng, Lihao Ge   +18 more
doaj   +1 more source

Palmitoylation-dependent modulation of CD36 trafficking and signaling integrates lipid uptake with metabolic disease pathogenesis

Pharmacological Research
CD36 is a multifunctional lipid transporter that facilitates long-chain fatty acid uptake and orchestrates metabolic signaling in energy-demanding tissues.
Mingxun Li, Haoran Jia, Lei Zhang, Peng Chen, Shimeng Wang, Yongjiang Mao, Zhangping Yang   +6 more
doaj   +1 more source

Molecular and cellular biology of infantile neuronal ceroid lipofuscinosis (INCL) [PDF]

, 2001
Väitöskirj
Salonen, Tarja
core  

Cyclical palmitoylation regulates TLR9 signalling and systemic autoimmunity in mice

Nature Communications
Toll-like receptor 9 (TLR9) recognizes self-DNA and plays intricate roles in systemic lupus erythematosus (SLE). However, the molecular mechanism regulating the endosomal TLR9 response is incompletely understood.
Hai Ni, Yinuo Wang, Kai Yao, Ling Wang, Jiancheng Huang, Yongfang Xiao, Hongyao Chen, Bo Liu, Cliff Y. Yang, Jijun Zhao   +9 more
doaj   +1 more source

Regulation of neurite morphogenesis by interaction between R7 regulator of G protein signaling complexes and G protein subunit Gα13 [PDF]

, 2017
Blumer, Kendall J, Cain, Matthew D, Kaltenbronn, Kevin M, Kanal, Stanley M, Scherer, Stephanie L   +4 more
core   +2 more sources