Results 131 to 140 of about 2,071 (166)

Protein palmitoylation: A potential therapeutic target in cardiovascular diseases. [PDF]

Acta Pharm Sin B
Zhao S, Yang Y, Li H, Sun P, He X, Wang C, Zhang J, Tian Y, Yu T, Jiang Z.   +9 more
europepmc   +1 more source

Protein palmitoylation: an emerging regulator of inflammatory signaling and diseases. [PDF]

Front Immunol
Chen R, Tang X, Wang Y, Wang B, Mao F.
europepmc   +1 more source

Palmitoylation in cardiovascular diseases: Molecular mechanism and therapeutic potential. [PDF]

Int J Cardiol Heart Vasc
Wang R, He Y, Wang Y, Wang J, Ding H.
europepmc   +1 more source

LYPLAL1 rare loss-of-function variants in humans and deletion in human hepatoma cells protect against MASLD. [PDF]

J Lipid Res
Hussain R, Raut C, Prabhu P, Irshaid A, Hegde Y, Chen Y, Pant A, Oliveri A, Wei X, Yin L, Russell TL, Halligan B, Semenkovich CF, Speliotes EK.   +13 more
europepmc   +1 more source

S-palmitoylation of MTDH regulates ferroptosis resistance in breast cancer cell. [PDF]

J Lipid Res
Pei S, Wang W, Feng T, Wang Q, Wang Y, Liu HX, Liang X, Piao HL.   +7 more
europepmc   +1 more source

Insights into the molecular basis of the palmitoylation and depalmitoylation of NCX1 [PDF]

Cell Calcium, 2021
Catalyzed by zDHHC-PAT enzymes and reversed by thioesterases, protein palmitoylation is the only posttranslational modification recognized to regulate the sodium/calcium exchanger NCX1.
Niall J Fraser, Caglar Gok, William Fuller   +2 more
exaly   +18 more sources

Palmitoylation and depalmitoylation defects [PDF]

Journal of Inherited Metabolic Disease, 2015
Palmitoylation describes the enzymatic attachment of a 16-carbon atom fatty acid to a target protein. Such lipidation events occur in all eukaryotes and can be of reversible (S-palmitoylation) or irreversible (N-palmitoylation) nature.
Thorsten Hornemann
exaly   +7 more sources

Amphiphile-Mediated Depalmitoylation of Proteins in Living Cells

Journal of the American Chemical Society, 2018
Post-translational S-palmitoylation plays a central role in protein localization, trafficking, stability, aggregation, and cell signaling. Dysregulation of palmitoylation pathways in cells can alter protein function and is the cause of several diseases ...
Roberto J Brea, Neal Devaraj, Andrew K Rudd   +2 more
exaly   +5 more sources

Palmitoylation and depalmitoylation dynamics at a glance [PDF]

Journal of Cell Science, 2010
Protein palmitoylation, the thioester linkage of fatty acyl moieties (typically, saturated 16C palmitate) to cysteine, is a lipid modification that serves both to tether proteins to membranes and to direct their localization to membrane microdomains.
Elizabeth Conibear
exaly   +4 more sources

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Activation and depalmitoylation of Gsα

Cell, 1994
[3H]palmitate attached to mutationally activated alpha s (alpha s-R201C) turns over rapidly, compared with palmitate linked to normal alpha s (t1/2 approximately 2 min versus 90 min); although alpha s-R201C (unlike normal alpha s) is predominantly found in the cytosol, [3H]palmitate is linked only to the membrane-bound pool of alpha s, normal or mutant.
Philip Wedegaertner, P B Wedegaertner, Henry R Bourne   +2 more
exaly   +2 more sources