Results 151 to 160 of about 2,071 (166)
APT1-derived depalmitoylation of CD36 alleviates diabetes-induced lipotoxicity in podocytes
International Journal of Biological SciencesCluster of Differentiation 36 (CD36), also known as scavenger receptor B2, plays a critical role in controlling podocyte lipid metabolism, mediating the onset and progression of diabetic kidney disease (DKD). However, the post-translational regulation of CD36 and its exact role in lipid transport within podocytes remain unclear.
Guohua Ding, Jijia Hu, Zijing Zhu
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Depalmitoylation and cell physiology: APT1 as a mediator of metabolic signals
American Journal of Physiology-Cell PhysiologyMore than half of the global population is obese or overweight, especially in Western countries, and this excess adiposity disrupts normal physiology to cause chronic diseases. Diabetes, an adiposity-associated epidemic disease, affects >500 million people, and cases are projected to exceed 1 billion before 2050.
Sarah L. Speck +2 more
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Activation and depalmitoylation of Gs alpha.
Cell, 1994[3H]palmitate attached to mutationally activated alpha s (alpha s-R201C) turns over rapidly, compared with palmitate linked to normal alpha s (t1/2 approximately 2 min versus 90 min); although alpha s-R201C (unlike normal alpha s) is predominantly found in the cytosol, [3H]palmitate is linked only to the membrane-bound pool of alpha s, normal or mutant.
P B, Wedegaertner, H R, Bourne
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Identifying the Potential Substrates of the Depalmitoylation Enzyme Acyl-protein Thioesterase 1
Current Molecular Medicine, 2019Background:The homeostasis of palmitoylation and depalmitoylation is involved in various cellular processes, the disruption of which induces severe physiological consequences. Acyl-protein thioesterase (APT) and palmitoyl-protein thioesterases (PPT) catalyze the depalmitoylation process.
Huicong, Liu +7 more
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Role of palmitoylation/depalmitoylation reactions in G-protein-coupled receptor function
Pharmacology & Therapeutics, 2003G-protein-coupled receptors (GPCRs) constitute one of the largest protein families in the human genome. They are subject to numerous post-translational modifications, including palmitoylation. This review highlights the dynamic nature of palmitoylation and its role in GPCR expression and function.
Riad, Qanbar, Michel, Bouvier
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Journal of Neuroscience Research, 2000
Palmitoyl protein thioesterase 1 (PPT1) removes palmitate from specific cysteine residues in peptides and proteins. We have previously shown that a palmitoylated myelin glycoprotein. Po octapeptide (IRYCWLRR) can be specifically depalmitoylated by PPT1 in vitro (Cho and Dawson [1998] J. Neurochem. 171 ;323-329).
S, Cho, P E, Dawson, G, Dawson
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Palmitoyl protein thioesterase 1 (PPT1) removes palmitate from specific cysteine residues in peptides and proteins. We have previously shown that a palmitoylated myelin glycoprotein. Po octapeptide (IRYCWLRR) can be specifically depalmitoylated by PPT1 in vitro (Cho and Dawson [1998] J. Neurochem. 171 ;323-329).
S, Cho, P E, Dawson, G, Dawson
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A palmitoylation–depalmitoylation relay spatiotemporally controls GSDMD activation in pyroptosis
Nature Cell BiologyGasdermin D (GSDMD) is the executor of pyroptosis, which is important for host defence against pathogen infection. Following activation, caspase-mediated cleavage of GSDMD releases an amino-terminal fragment (GSDMD-NT), which oligomerizes and forms pores in the plasma membrane, leading to cell death and release of proinflammatory cytokines. The spatial
Na Zhang +9 more
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