Results 101 to 110 of about 2,794 (185)

Transient Suppression of Dopamine Transporter Palmitoylation by Methamphetamine: Implications for Transport Regulation

The FASEB Journal, Volume 39, Issue 21, 15 November 2025.
This study examines the effects of METH on dopamine transporter (DAT) palmitoylation, a modification that enhances transport velocity and opposes PKC‐induced down‐regulation. In rats injected with METH, DAT palmitoylation was suppressed within minutes followed by a gradual return to control levels. METH‐induced transport down‐regulation occurred within
Moriah J. Hovde, Danielle E. Bolland, Corey D. Kleinsasser, Madhur Shetty, Aaron C. Blackwell, Mikhail Y. Golovko, Svetlana A. Golovko, Christopher R. Brown, James D. Foster, Roxanne A. Vaughan   +9 more
wiley   +1 more source

Inhibition of NRAS Signaling in Melanoma through Direct Depalmitoylation Using Amphiphilic Nucleophiles

ACS Chemical Biology, 2020
Activating mutations in the small GTPase NRAS are responsible for driving tumor growth in several cancers. Unfortunately, the development of NRAS inhibitors has proven difficult due to the lack of hydrophobic binding pockets on the protein's surface. To overcome this limitation, we chose to target the post-translational S-palmitoyl modification of NRAS,
Hetika D. Vora, Mai Johnson, Roberto J. Brea, Andrew K. Rudd, Neal K. Devaraj   +4 more
openaire   +3 more sources

Palmitoylation of human proteinase-activated receptor-2 differentially regulates receptor-triggered ERK1/2 activation, calcium signalling and endocytosis [PDF]

, 2011
hPAR2 (human proteinase-activated receptor-2) is a member of the novel family of proteolytically activated GPCRs (G-protein-coupled receptors) termed PARs (proteinase-activated receptors).
Alyn H. Morice, Andrew Botham, Bijlmakers, Blanpain, Bockaert, Bockaert, Bohm, Carvou, Compton, Compton, Compton, DeFea, Dery, Doi, Eason, Escriba, Hansen, Hawtin, Hayashi, Heuser, Jiang, Kawate, Klinger, Krasel, Krupnick, Kumar, Lafleur, Laura R. Sadofsky, Ma, McCoy, Melkonian, Moffett, Moffett, Molino, Moore, Munshi, Oh, Okamoto, Okamoto, Palmer, Percherancier, Petaja-Repo, Piersen, Ponimaskin, Qanbar, Rimoldi, Sadeghi, Seatter, Shenoy, Stalheim, Steven J. Compton, Wei, Xiaodan Guo, Yu Pei Xiao, Zoudilova   +54 more
core   +5 more sources

Enhancing Gpx1 palmitoylation to inhibit angiogenesis by targeting PPT1

Redox Biology
The significance of protein S-palmitoylation in angiogenesis has been largely overlooked, leaving various aspects unexplored. Recent identification of Gpx1 as a palmitoylated protein has generated interest in exploring its potential involvement in novel ...
Yidan Ma, Xinxin Yuan, Aodong Wei, Xiaopeng Li, Azim Patar, Shaobo Su, Songtao Wang, Gaoen Ma, Jiangli Zhu, Eryan Kong   +9 more
doaj   +1 more source

Breaking barriers: The cGAS‐STING pathway as a novel frontier in cancer immunotherapy

Cancer Communications, Volume 45, Issue 11, Page 1513-1546, November 2025.
Abstract Since its discovery, the cyclic GMP‐AMP synthase (cGAS)‐stimulator of the interferon gene (STING) signaling pathway has been considered a pivotal component of innate immunity and a promising target for cancer immunotherapy. Beyond its canonical role in pathogen defense, accumulating evidence has demonstrated that the cGAS‐STING pathway ...
Yuheng Yan, Ximin Tan, Bin Song, Ming Yi, Qian Chu, Kongming Wu   +5 more
wiley   +1 more source

Enzymatic Depalmitoylation of Viral Glycoproteins with Acyl-Protein Thioesterase 1 in Vitro

Virology, 2001
Many glycoproteins of enveloped viruses as well as cellular proteins are covalently modified with fatty acids. Palmitoylation is often reversible, but the enzymology of this hydrophobic protein modification is not understood. Recently a cytosolic enzyme designated acyl-protein thioesterase 1 (APT1) was purified, which depalmitoylates several cellular ...
Veit, Michael, Schmidt, Michael F.G.
openaire   +2 more sources

Amino acid residues 24-31 but not palmitoylation of cysteines 30 and 45 are required for membrane anchoring of glutamic acid decarboxylase, GAD65. [PDF]

, 1994
The smaller isoform of the GABA synthesizing enzyme glutamic acid decarboxylase, GAD65, is synthesized as a soluble protein that undergoes post-translational modification(s) in the NH2-terminal region to become anchored to the membrane of small synaptic ...
Baekkeskov, Steinunn, Shi, Y, Veit, B
core  

The PICK1 Ca2+ sensor modulates N-methyl-D-aspartate (NMDA) receptor-dependent microRNA-mediated translational repression in neurons [PDF]

, 2017
MicroRNAs (miRNAs) are important regulators of localized mRNA translation in neuronal dendrites. The presence of RNA-induced silencing complex proteins in these compartments and the dynamic miRNA expression changes that occur in response to neuronal ...
Fiuza, Maria, Hanley, Jonathan, Parkinson, Gabrielle, Rajgor, Dipen   +3 more
core   +2 more sources

CD9‐association with PIP2 areas is regulated by a CD9 salt bridge

FEBS Open Bio, Volume 15, Issue 10, Page 1678-1695, October 2025.
The tetraspanin CD9 has an intracellular salt bridge. If CD9 opens, open‐CD9 moves from PIP2‐rich areas to regions populated by its interaction partner EWI‐2. Hence, the state of the salt bridge regulates the distribution of CD9 and by this CD9‐EWI‐2 complex formation.
Yahya Homsi, Sara C. Konopka, Thorsten Lang   +2 more
wiley   +1 more source

Swine RNF5 positively regulates the antiviral activity of IFITM1 by mediating the degradation of ABHD16A

Journal of Virology
Interferon-inducible transmembrane (IFITM) proteins are broad-spectrum antiviral factors that confer cellular resistance to virus invasion. α/β-Hydrolase domain-containing 16A (ABHD16A) has recently been identified as a novel depalmitoylase that can ...
Xuemeng Shi, Lingyi Shen, Shuaiwu Chen, Mingyang Liu, Jingyi Wang, Xin Wen, Wei Liu, Lin Mao, Yunyun Ding, Li Yu, Jun Xu   +10 more
doaj   +1 more source