Results 81 to 90 of about 2,071 (166)

Dual Regulation of Sprouty 4 Palmitoylation by ZDHHC7 and Palmitoyl-Protein Thioesterase 1: A Potential Therapeutic Strategy for Cisplatin-Resistant Osteosarcoma

Research
Background: Osteosarcoma (OS) is a primary malignant bone tumor predominantly affecting adolescents. Chemotherapeutic agents, such as cisplatin, are commonly used in OS treatment; however, drug resistance markedly undermines treatment efficacy and ...
Tianlong Huang, Yifan Chen, Qiangqiang Zhao, Xin Wu, Hongxing Li, Xin Luo, Yang Su, Shengqun Zhang, Pan Liu, Ning Tang   +9 more
doaj   +1 more source

Wnt5a signaling induced phosphorylation increases APT1 activity and promotes melanoma metastatic behavior

eLife, 2018
Wnt5a has been implicated in melanoma progression and metastasis, although the exact downstream signaling events that contribute to melanoma metastasis are poorly understood.
Rochelle Shirin Sadeghi, Katarzyna Kulej, Rahul Singh Kathayat, Benjamin A Garcia, Bryan C Dickinson, Donita C Brady, Eric S Witze   +6 more
doaj   +1 more source

A functional screen implicates microRNA-138-dependent regulation of the depalmitoylation enzyme APT1 in dendritic spine morphogenesis

, 2009
The microRNA pathway has been implicated in the regulation of synaptic protein synthesis and ultimately in dendritic spine morphogenesis, a phenomenon associated with long-lasting forms of memory.
Fiore, R, Bicker, S, Rengarajan, B., Draguhn, A, Gregor Obernosterer, Hedberg, C., Drepper, C., Martin Oehmen, Greenberg, M E, Oehmen, Martin, Hübel, K, Hedberg, Christian, Gerhard M. Schratt, Martinez, J., Leuschner, Philipp F, Rehmsmeier, M, Obernosterer, G, Schratt, Gerhard M., Greenberg, Michael E., Hübel, Katja, Christensen, M., Waldmann, H., Gabriele Siegel, Leuschner, P F, Draguhn, A., Khudayberdiev, S, Kauppinen, Sakari, Christina Kane, Michael E. Greenberg, Kauppinen, S, Bicker, S., Christensen, M, Kauppinen, S., Kane, C, Greenberg, Michael E, Fiore, Roberto, Carsten Drepper, Busch, C., Fiore, R., Dekker, Frank, Katja Hübel, Marc Rehmsmeier, Siegel, G., Leuschner, P., Dekker, F., Drepper, C, Waldmann, Herbert, Draguhn, Andreas, Obernosterer, Gregor, Bicker, Silvia, Oehmen, M, Frank Dekker, Martinez, J, Kane, Christina, Sharof Khudayberdiev, Roberto Fiore, Clara J. L. Busch, Leuschner, Philipp F., Busch, Clara J L, Greenberg, M., Siegel, G, Javier Martinez, Schratt, G M, Herbert Waldmann, Andreas Draguhn, Martinez, Javier, Sakari Kauppinen, Rehmsmeier, M., Rengarajan, Balamurugan, Hedberg, C, Rengarajan, B, Kane, C., Rehmsmeier, Marc, Schratt, Gerhard M, Hübel, K., Schratt, G., Silvia Bicker, Huebel, Katja, Khudayberdiev, S., Busch, C J L, Christian Hedberg, Balamurugan Rengarajan, Waldmann, H, Siegel, Gabriele, Busch, Clara J. L., Philipp F. Leuschner, Christensen, Mette, Obernosterer, G., Dekker, F, Drepper, Carsten, Khudayberdiev, Sharof, Mette Christensen, Oehmen, M.   +92 more
core   +1 more source

PPT1-mediated depalmitoylation facilitates disulfide bond formation.

, 2022
(A) Schematic of modified Acyl RAC. (i) Free thiols were blocked with NEM prior to reduction of disulfide bonds with TCEP. (ii) Free thiols generated by TCEP treatment were modified with heavy-labeled NEM (dNEM). iii.
Sreeganga S. Chandra (12329746), Vicky Chou (12329740), Helen R. Zhao (12329737), Sofia Massaro Tieze (12329731), TuKiet T. Lam (610361), Betül Yücel (12329734), Gregory S. Wirak (12329743), Susumu Tomita (6956876), Erica L. Gorenberg (12329728)   +8 more
core   +1 more source

Spatial regulation of the acylation cycle by thioesterase auto-depalmitoylation

, 2015
The acylation cycle is a reaction diffusion mechanism thatmaintains H/N-Ras localization on the plasma membrane (PM)by countering the equilibration of palmitoylated H/N-Rasproteins to endomembranes. The thioesterases APT1/2perform this critical function of depalmitoylating mislocalizedH/N-Ras proteins, thereby allowing them to diffuse rapidly andre ...
Vartak, Nachiket, Papke, Bjoern, Christian Hedberg, Rossmanek, Lisaweta   +3 more
openaire   +1 more source

Characterisation of a family of Putative Acyl Serine Hydrolases in Toxoplasma gondii

, 2013
Post-translational modifications are a regulatory mechanism for fine-tuning protein localisation and function. S-palmitoylation is a reversible lipid modification that causes an increased affinity for membranes in its substrates.
Kemp, Louise
core   +1 more source

Defective anterograde protein-trafficking contributes to endoplasmic reticulum-stress in a CLN1 disease model

Neurobiology of Disease
Lysosomal storage disorders (LSDs) represent 70 inherited metabolic diseases, in most of which neurodegeneration is a devastating manifestation. The CLN1 disease is a fatal neurodegenerative LSD, caused by inactivating mutations in the CLN1 gene encoding
Nisha Plavelil, Abhilash P. Appu, K.C. Gopal, Avisek Mondal, Neil Perkins, Anil B. Mukherjee   +5 more
doaj   +1 more source

Regulating Ras Trafficking with FKPB12

, 2011
By promoting Ras depalmitoylation, the prolyl isomerase FKBP12 regulates Ras trafficking and activity.
Nancy R. Gough
core   +1 more source

Distinct acyl protein transferases and thioesterases control surface expression of calcium-activated potassium channels [PDF]

, 2012
Protein palmitoylation is rapidly emerging as an important determinant in the regulation of ion channels, including large conductance calcium-activated potassium (BK) channels. However, the enzymes that control channel palmitoylation are largely unknown.
McClafferty, Heather, Ruth, Peter, Tian, Lijun, Shipston, Michael J, Knaus, Hans-Guenther   +4 more
core   +1 more source

Analysis and validation of novel biomarkers related to palmitoylation in adenomyosis

Frontiers in Genetics
BackgroundAdenomyosis, a common gynecological disorder in women of reproductive age, is characterized by endometrial invasion into the myometrium, leading to uterine enlargement and smooth muscle hypertrophy.
Hongyu Zhang, Yufeng Li, Huijuan Cao, Yiling Zhao, Hongwen Zhu, Tiansheng Qin   +5 more
doaj   +1 more source