Results 61 to 70 of about 2,794 (185)
Palmitoylation of Plasmodium alveolins promotes cytoskeletal function. [PDF]
, 2017 S-palmitoylation is a post-translational lipid modification that is widespread among Plasmodium proteins and essential for parasite development. Little is known about the contribution of palmitoylation to the function of individual parasite molecules and
Al-Khattaf, Fatimah S +2 more
core +1 more source
Peroxiredoxin 6 mediates Gαi protein-coupled receptor inactivation by cJun kinase
Nature Communications, 2017 Opioid receptors are important modulators of nociceptive pain. Here the authors show that opioid receptor activation recruits peroxiredoxin 6 (PRDX6) to the receptor-Gαi complex by c-Jun N-terminal kinase, resulting in Gαi depalmitoylation and enhanced ...
Selena S. Schattauer +8 more
doaj +1 more source
Regenerative Therapy, 2023 Objective: Senile osteoporosis (SOP) is an aging-related disease. The depalmitoylating enzyme Acyl-protein thiesterase1 (APT1) is involved in disease regulation. This study explored the mechanism of APT1 in SOP.
Changjiao Ji +6 more
doaj +1 more source
Advanced Science, EarlyView.This study identifies palmitoylation as a novel regulatory modification of SMAD4, mediated by ZDHHC22/APT2. It activates fatty acid synthesis, creating a self‐reinforcing SMAD4–FASN–palmitate feedback loop that drives pancreatic cancer growth and enhances radiotherapy sensitivity.
Yang Wang +16 more
wiley +1 more source
Metabolic Labeling of Ras with Tritiated Palmitate to Monitor Palmitoylation and Depalmitoylation [PDF]
, 2013 Metabolic labeling with tritiated palmitate is a direct method for monitoring posttranslational modification of Ras proteins with this fatty acid. Advances in intensifying screens have allowed for the easy visualization of tritium without the need for extended exposure times.
Frederick D, Tsai +3 more
openaire +2 more sources
Specific oligomerization of the 5-HT1A receptor in the plasma membrane [PDF]
, 2009 In the present study we analyze the oligomerization of the 5-HT1A receptor within living cells at the sub-cellular level. Using a 2-excitation Foerster Resonance Energy Transfer (FRET) method combined with spectral microscopy we are able to estimate the ...
Andrew Woehler +34 more
core +2 more sources
Protein palmitoylation in cancer: molecular functions and therapeutic potential
Molecular Oncology, 2023 Protein S‐palmitoylation (hereinafter referred to as protein palmitoylation) is a reversible lipid posttranslational modification catalyzed by the zinc finger DHHC‐type containing (ZDHHC) protein family.
Binhui Zhou +3 more
doaj +1 more source
Advanced Science, EarlyView.Hepatocellular carcinoma (HCC)‐derived extracellular vesicles (EVs) enrich the metabolic enzyme ATP‐citrate lyase (ACLY). EV‐transferred ACLY enhances palmitate biosynthesis, increases the S‐palmitoylation and stability of multiple immune checkpoint proteins, augments the cellular immunosuppressive activity, and ultimately accelerates the malignant ...
Zhijun Liu +11 more
wiley +1 more source
Depalmitoylated Ras traffics to and from the Golgi complex via a nonvesicular pathway [PDF]
The Journal of Cell Biology, 2005 Palmitoylation is postulated to regulate Ras signaling by modulating its intracellular trafficking and membrane microenvironment. The mechanisms by which palmitoylation contributes to these events are poorly understood. Here, we show that dynamic turnover of palmitate regulates the intracellular trafficking of HRas and NRas to and from the Golgi ...
Goodwin, J. Shawn +6 more
openaire +2 more sources
Palmitoyl Acyltransferase DHHC21 Mediates Endothelial Dysfunction in Systemic Inflammatory Response Syndrome [PDF]
, 2016 Endothelial dysfunction is a hallmark of systemic inflammatory response underlying multiple organ failure. Here we report a novel function of DHHC-containing palmitoyl acyltransferases (PATs) in mediating endothelial inflammation.
Beard, Richard S., Jr.
core +1 more source