Results 31 to 40 of about 2,794 (185)
PLoS Biology, 2022 Loss-of-function mutations in the depalmitoylating enzyme palmitoyl protein thioesterase 1 (PPT1) cause neuronal ceroid lipofuscinosis (NCL), a devastating neurodegenerative disease.
Erica L Gorenberg +8 more
doaj +1 more source
Hepatology, EarlyView., 2022 KAT7‐acetylated and cytoplasm‐translocated G‐protein GαS enhances IL‐6 effect and drives HCC progenitor cell progression. Abstract Background and Aims Hepatocarcinogenesis goes through HCC progenitor cells (HcPCs) to fully established HCC, and the mechanisms driving the development of HcPCs are still largely unknown.
Ye Zhou +15 more
wiley +1 more source
Identification of PSD-95 Depalmitoylating Enzymes [PDF]
The Journal of Neuroscience, 2016 Postsynaptic density (PSD)-95, the most abundant postsynaptic scaffolding protein, plays a pivotal role in synapse development and function. Continuous palmitoylation cycles on PSD-95 are essential for its synaptic clustering and regulation of AMPA receptor function.
Norihiko, Yokoi +5 more
openaire +2 more sources
APT1-Mediated Depalmitoylation Regulates Hippocampal Synaptic Plasticity
The Journal of Neuroscience, 2022 Palmitoylation may be relevant to the processes of learning and memory, and even disorders, such as post-traumatic stress disorder and aging-related cognitive decline. However, underlying mechanisms of palmitoylation in these processes remain unclear. Herein, we used acyl-biotin exchange, coimmunoprecipitation and biotinylation assays, and behavioral ...
Zu-Cheng Shen +12 more
openaire +2 more sources
Palmitoylation and depalmitoylation defects [PDF]
Journal of Inherited Metabolic Disease, 2014 AbstractPalmitoylation describes the enzymatic attachment of a 16‐carbon atom fatty acid to a target protein. Such lipidation events occur in all eukaryotes and can be of reversible (S‐palmitoylation) or irreversible (N‐palmitoylation) nature. In particular S‐palmitoylation is dynamically regulated by two opposing types of enzymes which add (palmitoyl ...
openaire +4 more sources
ABHD16A Negatively Regulates the Palmitoylation and Antiviral Function of IFITM Proteins
mBio, 2022 Interferon-inducible transmembrane (IFITM) proteins are small homologous proteins that are encoded by the interferon-stimulated genes (ISGs), which can be strongly induced by interferon (IFN) and provide resistance to invasion by a variety of viral ...
Xuemeng Shi +8 more
doaj +1 more source
A cluster of palmitoylated cysteines are essential for aggregation of cysteine-string protein mutants that cause neuronal ceroid lipofuscinosis [PDF]
, 2017 Autosomal-dominant adult-onset neuronal cero id lipofuscinosis (ANCL) is caused by mutation of the DNAJC5 gene encoding cysteine string protein alpha (CSP α ). The disease- causing mutations, which result in substituti on of leucine-115 with an arginine (
Chamberlain, Luke H. +4 more
core +1 more source
Cardiac sodium channel palmitoylation regulates channel availability and myocyte excitability with implications for arrhythmia generation [PDF]
, 2016 Cardiac voltage-gated sodium channels (Nav1.5) play an essential role in regulating cardiac electric activity by initiating and propagating action potentials in the heart.
Cummins, Theodore R. +4 more
core +1 more source
ATP-independent Control of Vac8 Palmitoylation by a SNARE Subcomplex on Yeast Vacuoles [PDF]
, 2005 Yeast vacuole fusion requires palmitoylated Vac8. We previously showed that Vac8 acylation occurs early in the fusion reaction, is blocked by antibodies against Sec18 (yeast N-ethylmaleimide-sensitive fusion protein (NSF)), and is mediated by the R-SNARE
Cristodero, Marina +5 more
core +1 more source
Palmitoylated ras proteins traffic through recycling endosomes to the plasma membrane during exocytosis [PDF]
, 2010 Ras proteins regulate cell growth, death, and differentiation, and it is well established that this functional versatility is accomplished through their different subcellular localizations.
Ang +38 more
core +1 more source