Protein S-palmitoylation regulates the virulence of plant pathogenic fungi [PDF]
mBioProtein S-palmitoylation, a universal posttranslational modification catalyzed by a specific group of palmitoyltransferases, plays crucial roles in diverse biological processes across organisms by modulating protein functions.
Mengmeng Guo, Leeza Tariq, Fengming Song
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Targeted degradation of zDHHC-PATs decreases substrate S-palmitoylation. [PDF]
PLoS OneReversible S-palmitoylation of protein cysteines, catalysed by a family of integral membrane zDHHC-motif containing palmitoyl acyl transferases (zDHHC-PATs), controls the localisation, activity, and interactions of numerous integral and peripheral membrane proteins.
Bai M +11 more
europepmc +6 more sources
Differential S-palmitoylation of the human and rodent β3-adrenergic receptors [PDF]
Journal of Biological Chemistry, 2019 With few reported exceptions, G protein-coupled receptors (GPCRs) are modified by Cys palmitoylation (S-palmitoylation). In multiple GPCRs, S-palmitoylation targets a canonical site within the C-terminal cytoplasmic tail adjacent to the C terminus of the seventh transmembrane domain, but modification of additional sites is exemplified by the β ...
Naoko Adachi +5 more
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Acta Pharmaceutica Sinica B, 2015 Glutamate acting on AMPA-type ionotropic glutamate receptor (AMPAR) mediates the majority of fast excitatory synaptic transmission in the mammalian central nervous system.
Jun Han +3 more
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Position of Proline Mediates the Reactivity of S-Palmitoylation
ACS Chemical Biology, 2015 Palmitoylation, a post-translational modification in which a saturated 16-carbon chain is added predominantly to a cysteine residue, participates in various biological functions. The position of proline relative to other residues being post-translationally modified has been previously reported as being important.
Neelam, Khanal +5 more
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Function of Protein S-Palmitoylation in Immunity and Immune-Related Diseases [PDF]
Frontiers in Immunology, 2021 Protein S-palmitoylation is a covalent and reversible lipid modification that specifically targets cysteine residues within many eukaryotic proteins. In mammalian cells, the ubiquitous palmitoyltransferases (PATs) and serine hydrolases, including acyl ...
Yuqi Zhang +4 more
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Temporal Profiling Establishes a Dynamic S‑Palmitoylation Cycle
, 2018 S-palmitoylation is required for membrane anchoring, proper trafficking, and the normal function of hundreds of integral and peripheral membrane proteins.
Brent R. Martin (163859) +1 more
core +7 more sources
S-palmitoylation modulates ATG2-dependent non-vesicular lipid transport during starvation-induced autophagy [PDF]
The EMBO JournalLipid transfer proteins mediate the non-vesicular transport of lipids at membrane contact sites to regulate the lipid composition of organelle membranes. Despite significant recent advances in our understanding of the structural basis for lipid transfer,
Wenhui Zheng +9 more
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Zinc finger DHHC-type palmitoyltransferase 13-mediated S-palmitoylation of GNA13 from Sertoli cell-derived extracellular vesicles inhibits autophagy in spermatogonial stem cells [PDF]
Cell Communication and SignalingExtracellular vesicles (EVs) originating from testicular somatic cells act as pivotal intermediaries in cell signaling crosstalk between spermatogenic cells and the testicular microenvironment.
Heran Cao +9 more
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cGMP signalling regulates S-palmitoylation in sensory neurons
, 2017 During the development of the vertebrate nervous system, neurons from the central and the peripheral nervous systems generate an axon which navigates through the tissues. In many cases it might innervate multiple target regions by forming branches and by this build a complex and well-ordered network.
Dumoulin, Alexandre
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