Results 21 to 30 of about 21,089,371 (171)

Akt Is S-Palmitoylated: A New Layer of Regulation for Akt [PDF]

Frontiers in Cell and Developmental Biology, 2021
The protein kinase Akt/PKB participates in a great variety of processes, including translation, cell proliferation and survival, as well as malignant transformation and viral infection. In the last few years, novel Akt posttranslational modifications have been found.
Matías Blaustein, Matías Blaustein, Matías Blaustein, Estefanía Piegari, Estefanía Piegari, Camila Martínez Calejman, Antonella Vila, Antonella Vila, Antonella Vila, Analía Amante, Analía Amante, Analía Amante, María Victoria Manese, Ari Zeida, Laurence Abrami, Mariela Veggetti, Mariela Veggetti, David A. Guertin, David A. Guertin, David A. Guertin, F. Gisou van der Goot, María Martha Corvi, Alejandro Colman-Lerner, Alejandro Colman-Lerner   +23 more
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cGMP signalling regulates S-palmitoylation in sensory neurons

, 2017
During the development of the vertebrate nervous system, neurons from the central and the peripheral nervous systems generate an axon which navigates through the tissues. In many cases it might innervate multiple target regions by forming branches and by this build a complex and well-ordered network.
Dumoulin, Alexandre
core   +2 more sources

Protein S -palmitoylation in immunity [PDF]

Open Biology, 2021
S -palmitoylation is a reversible posttranslational lipid modification of proteins. It controls protein activity, stability, trafficking and protein–protein interactions. Recent global profiling of immune cells and targeted analysis have identified many S -palmitoylated ...
Tandrila Das, Jacob S. Yount, Howard C. Hang   +2 more
openaire   +3 more sources

S-palmitoylation and the regulation of NCX1 [PDF]

Channels, 2015
Investigations into reversible cysteine acylation (S-palmitoylation) have enjoyed a renaissance recently, thanks to numerous techniques that have improved the sensitivity of detection above the tra...
Fuller, William, Reilly, Louise, Hilgemann, Donald W.   +2 more
openaire   +3 more sources

Palmitoylation-Dependent Small-Molecule Fluorescent Probes for Live-Cell Golgi Imaging

, 2023
Small-molecule fluorescent probes enabling visualization of the Golgi apparatus in living cells are essential tools for studying Golgi-associated biological processes and diseases.
Emi Mishiro-Sato (14426149), Shunsuke Sawada, Keiko Kano (493477), Masaru Yoshikawa (10691876), Masaru Yoshikawa, Emi Mishiro-Sato, Keita Tsutsui (15354549), Keiko Kano, Shinya Tsukiji, Shinya Tsukiji (1919149), Shunsuke Sawada (5982365), Keita Tsutsui, Tomoki Miyazaki (15354552), Tomoki Miyazaki   +13 more
core   +3 more sources

S-Palmitoylation of Tyrosinase at Cysteine500 Regulates Melanogenesis

Journal of Investigative Dermatology, 2023
Palmitoylation is a lipid modification involving the attachment of palmitic acid to a cysteine residue, thereby affecting protein function. We investigated the effect of palmitoylation of tyrosinase, the rate-limiting enzyme in melanin synthesis, using a human three-dimensional skin model system and melanocyte culture.
Yoko Niki, Naoko Adachi, Masaki Fukata, Yuko Fukata, Shinichiro Oku, Chieko Makino-Okamura, Seiji Takeuchi, Kazumasa Wakamatsu, Shosuke Ito, Lieve Declercq, Daniel B. Yarosh, Tomas Mammone, Chikako Nishigori, Naoaki Saito, Takehiko Ueyama   +14 more
openaire   +2 more sources

Functional Analysis of Protein S-Palmitoylation Enzymes. [PDF]

, 2015
Protein S-palmitoylation is a dynamic, hydrophobic, post-translational modification of cysteine residues that is required for the spatiotemporal organization of hundreds of proteins.
Davda, Dahvid
core   +7 more sources

S-Palmitoylation and S-Oleoylation of Rabbit and Pig Sarcolipin [PDF]

Journal of Biological Chemistry, 2014
Sarcolipin (SLN) is a regulatory peptide present in sarcoplasmic reticulum (SR) from skeletal muscle of animals. We find that native rabbit SLN is modified by a fatty acid anchor on Cys-9 with a palmitic acid in about 60% and, surprisingly, an oleic acid in the remaining 40%. SLN used for co-crystallization with SERCA1a (Winther, A.
Montigny, Cédric, Decottignies, Paulette, Le Maréchal, Pierre, Capy, Pierre, Bublitz, Maike, Olesen, Claus, Møller, Jesper Vuust, Nissen, Poul, Le Maire, Marc   +8 more
openaire   +2 more sources

Palmitoylation-induced aggregation of cysteine-string protein mutants that cause neuronal ceroid lipofuscinosis [PDF]

, 2012
Recently, mutations in the DNAJC5 gene encoding cysteine-string protein alpha (CSPα) were identified to cause the neurodegenerative disorder adult-onset neuronal ceroid lipofuscinosis.
Greaves, J., Chamberlain, Luke, Chamberlain, L. H., Grefen, C., Lemonidis, K., Cruchaga, Carlos, Greaves, Jennifer, Grefen, Christopher, Lemonidis, Kimon, Gorleku, Oforiwa, Cruchaga, C., Gorleku, O. A.   +11 more
core   +1 more source

S-palmitoylation determines TMEM55B-dependent positioning of lysosomes

Journal of Cell Science, 2021
ABSTRACT The spatiotemporal cellular distribution of lysosomes depends on active transport mainly driven by microtubule motors such as kinesins and dynein. Different protein complexes attach these molecular motors to their vesicular cargo. TMEM55B (also known as PIP4P1), as an integral lysosomal membrane protein, is a component of such a
Sönke Rudnik, Saskia Heybrock, Paul Saftig, Markus Damme   +3 more
openaire   +2 more sources