Results 61 to 70 of about 21,089,371 (171)

ZDHHC12-mediated claudin-3 S-palmitoylation determines ovarian cancer progression

Acta Pharmaceutica Sinica B, 2020
The membrane protein claudin-3 (CLDN3) is critical for the formation and maintenance of tight junction and its high expression has been implicated in dictating malignant progression in various cancers.
Meng Yuan, Xiaobing Chen, Yitang Sun, Li Jiang, Zhongni Xia, Kaixiong Ye, Hong Jiang, Bo Yang, Meidan Ying, Ji Cao, Qiaojun He   +10 more
doaj   +1 more source

Semaglutide normalizes increased cardiomyocyte calcium transients in a rat model of high fat diet‐induced obesity

ESC Heart Failure, Volume 12, Issue 2, Page 1386-1397, April 2025.
Sequeira et al. reveal how the glucagon‐like peptide‐1 receptor agonist (GLP‐1‐RA) semaglutide restores cardiomyocyte function in rats subjected to a high‐fat/high‐fructose diet (HFD). Employing fluorescence‐ and patch‐clamp technology in isolated cardiac myocytes, they demonstrate that semaglutide reverses HFD‐induced activation of L‐type calcium ...
Vasco Sequeira, Julia Theisen, Katharina J. Ermer, Marie Oertel, Anton Xu, David Weissman, Katharina Ecker, Jan Dudek, Martin Fassnacht, Alexander Nickel, Michael Kohlhaas, Christoph Maack, Ulrich Dischinger   +12 more
wiley   +1 more source

Temporal and protein-specific S-palmitoylation supports synaptic and neural network plasticity

Cellular and Molecular Life Sciences
Background Synaptic plasticity, a fundamental process underlying learning and memory, depends on activity-driven changes in neural connectivity. S-palmitoylation, a reversible post-translational lipid modification, modulates synaptic protein function by ...
Agata Pytyś, Rabia Ijaz, Anna Buszka, Jacek Miłek, Izabela Figiel, Patrycja Wardaszka-Pianka, Matylda Roszkowska, Natalia Mierzwa, Adam Wojtas, Eli Kerstein, Remigiusz Serwa, Katarzyna Kalita, Rhonda Dzakpasu, Magdalena Dziembowska, Jakub Włodarczyk, Tomasz Wójtowicz   +15 more
doaj   +1 more source

Palmitoylation of ACE2 at Cys141, Cys344, and Cys498 facilitates its extracellular vesicles localization [PDF]

Jichu yixue yu linchuang
Objective To identify S-palmitoylation sites on angiotensin-converting enzyme 2(ACE2), the cellular receptor for severe acute respiratory syndrome corona virus(SARS-CoV) and SARS-CoV-2, and to investigate the functional relevance of these modifications ...
YANG Jingjing, MA Yan, WANG Yue, SUN Yang, LI Pan, GUO Feng
doaj   +1 more source

S-Palmitoylation of the sodium channel Nav1.6 regulates its activity and neuronal excitability

, 2020
S-Palmitoylation is a reversible post-translational lipid modification that dynamically regulates protein functions. Voltage-gated sodium channels are subjected to S-palmitoylation and exhibit altered functions in different S-palmitoylation states.
Zifan Pei, Yanling Pan, Cummins, Theodore R., Theodore R. Cummins, Yucheng Xiao, Pei, Zifan, Pan, Yanling, Xiao, Yucheng   +7 more
core   +1 more source

Palmitoylation enhances the stability of porcine epidemic diarrhea virus spike protein by antagonizing its degradation via chaperone-mediated autophagy to facilitate viral proliferation

Journal of Virology
Porcine epidemic diarrhea (PED) is a highly pathogenic and infectious intestinal disease caused by the PED virus (PEDV) and has inflicted substantial economic losses on the global swine industry. Therefore, it is imperative to explore appropriate targets
Qisheng Qian, Shuang-shuang Zhao, Lei Yang, Guangxu Xing, Yumei Chen, Chao Liang, Haili Wang, Rui Li, Songlin Qiao, Aiping Wang, Gaiping Zhang   +10 more
doaj   +1 more source

Mass Spectrometry Insights Into Post‐Translational Modifications in Extracellular Vesicles

Mass Spectrometry Reviews, EarlyView.
ABSTRACT Extracellular vesicles (EVs) are membrane‐enclosed structures secreted by virtually all living cells, serving as essential mediators of intercellular communication in both physiological and pathological processes. There is growing interest in their potential applications as biomarkers, therapeutic targets, and drug delivery systems, which ...
Dávid Virág, Krisztián Márk Karvaly, Alexandra Molnár, Mirjam Balbisi, Júlia Németh, Lilla Turiák   +5 more
wiley   +1 more source

S-Palmitoylation of γ-Secretase Subunits Nicastrin and APH-1 [PDF]

Journal of Biological Chemistry, 2009
Proteolytic processing of amyloid precursor protein (APP) by beta- and gamma-secretases generates beta-amyloid (Abeta) peptides, which accumulate in the brains of individuals affected by Alzheimer disease. Detergent-resistant membrane microdomains (DRM) rich in cholesterol and sphingolipid, termed lipid rafts, have been implicated in Abeta production ...
Haipeng, Cheng, Kulandaivelu S, Vetrivel, Renaldo C, Drisdel, Xavier, Meckler, Ping, Gong, Jae Yoon, Leem, Tong, Li, Meghan, Carter, Ying, Chen, Phuong, Nguyen, Takeshi, Iwatsubo, Taisuke, Tomita, Philip C, Wong, William N, Green, Maria Z, Kounnas, Gopal, Thinakaran   +15 more
openaire   +2 more sources

Cell Labeling with 15-YNE Is Useful for Tracking Protein Palmitoylation and Metabolic Lipid Flux in the Same Sample

Molecules
Protein S-palmitoylation is the process by which a palmitoyl fatty acid is attached to a cysteine residue of a protein via a thioester bond. A range of methodologies are available for the detection of protein S-palmitoylation.
Nadine Merz, Karin Schilling, Dominique Thomas, Lisa Hahnefeld, Sabine Grösch   +4 more
doaj   +1 more source

Precision Medicine in Neurodegeneration with Brain Iron Accumulation (NBIA) Disorders: An Update on Emerging Treatments

Movement Disorders Clinical Practice, EarlyView.
Abstract Background Neurodegeneration with Brain Iron Accumulation (NBIA) is a heterogeneous group of heritable, mostly recessive, progressive neurodegenerative diseases characterized by iron deposition in the basal ganglia and brainstem. There are no solid global epidemiological data on prevalence and incidence of NBIA subtypes, but registry data and ...
Susanne A. Schneider, Divyani Garg, Vassilena Iankova, Thomas Klopstock   +3 more
wiley   +1 more source