Results 71 to 80 of about 21,089,371 (171)

Selective Enrichment and Direct Analysis of Protein S-Palmitoylation Sites [PDF]

Journal of Proteome Research, 2018
S-Fatty-acylation is the covalent attachment of long chain fatty acids, predominately palmitate (C16:0, S-palmitoylation), to cysteine (Cys) residues via a thioester linkage on proteins. This post-translational and reversible lipid modification regulates protein function and localization in eukaryotes and is important in mammalian physiology and human ...
Emmanuelle Thinon, Joseph P. Fernandez, Henrik Molina, Howard C. Hang   +3 more
openaire   +2 more sources

From lipid modification to cell death: the diverse roles of S-palmitoylation in cell fate decisions

Cell Communication and Signaling
S-palmitoylation is a dynamic, reversible lipid modification that plays a crucial role in the regulation of various types of cell death. However, systematic insights into how S-palmitoylation modifications integrate and mediate crosstalk among diverse ...
Yue Zhu, Chunyu Ma, Liping Zhong, Tingting Wang, Weiwei Liu, Zishu Wang   +5 more
doaj   +1 more source

Protein palmitoylation in cancer: molecular functions and therapeutic potential

Molecular Oncology, 2023
Protein S‐palmitoylation (hereinafter referred to as protein palmitoylation) is a reversible lipid posttranslational modification catalyzed by the zinc finger DHHC‐type containing (ZDHHC) protein family.
Binhui Zhou, Qianyun Hao, Yinming Liang, Eryan Kong   +3 more
doaj   +1 more source

Identification of Yeast Protein Sequences With Similarity to the ESCRT‐III Protein Snf7

Yeast, EarlyView.
ABSTRACT Endosomal sorting complex required for transport (ESCRT‐III) is a membrane remodeling complex involved in a large number of cellular processes. It appears to perform an essential function in eukaryotes, since to date no eukaryotic organism completely devoid of ESCRT‐III has been found.
Thomas Brune, Ralf Kölling
wiley   +1 more source

Decreased protein S-palmitoylation in dorsolateral prefrontal cortex in schizophrenia [PDF]

Schizophrenia Research, 2016
Recent reports suggest abnormalities of neurotransmitter receptor trafficking, targeting, dendritic localization, recycling, and degradation in the brain in schizophrenia. We hypothesized that a potential explanation for these findings may be abnormal posttranslational modifications that influence intracellular targeting and trafficking of proteins ...
Anita L, Pinner, Janusz, Tucholski, Vahram, Haroutunian, Robert E, McCullumsmith, James H, Meador-Woodruff   +4 more
openaire   +2 more sources

New biosensors and transgenic mice for multiplex cGMP imaging

British Journal of Pharmacology, EarlyView.
Background and Purpose Cyclic guanosine monophosphate (cGMP) is a versatile second messenger that is important for human (patho‐)physiology and pharmacotherapy. Live‐cell imaging of cGMP with biosensors allows to elucidate its spatiotemporal dynamics in real time under close‐to‐native conditions. However, to monitor two separate cGMP pools or cGMP/cAMP
Markus Wolters, Martin Thunemann, Barbara Birk, Susanne Feil, Viacheslav O. Nikolaev, Moritz Lehners, Robert Feil   +6 more
wiley   +1 more source

Lipid-induced S-palmitoylation of Insulin-Responsive Aminopeptidase (IRAP) drives the onset of insulin resistance in the heart

Cellular and Molecular Life Sciences
Excessive accumulation of long-chain fatty acids (LCFAs) in cardiomyocytes leads to cardiac lipid-induced insulin resistance (CLIR), impairing insulin signaling and glucose uptake.
Francesco Schianchi, Jeroen Guns, Freek G. Bouwman, Jeroen F.J. Bogie, Miranda Nabben, Agnieszka Strzelecka, Rick van Leeuwen, Dimitris Kapsokalyvas, Kaitlyn M.J.H. Dennis, Lisa C. Heather, Shujin Wang, Jan F.C. Glatz, Dietbert Neumann, Joost J.F.P. Luiken   +13 more
doaj   +1 more source

PDE4D and PDE3B orchestrate distinct cAMP microdomains in 3T3‐L1 adipocytes

British Journal of Pharmacology, EarlyView.
Basal conditions: •Ins/PDE3B lowers cytoplasmic cAMP (cyt‐cAMP) without affecting plasma membrane cAMP (pm‐cAMP). •Insulin decreases lipid droplet cAMP (LD‐cAMP) independent of PDE3B. •FGF1/PDE4D modestly reduces both cyt‐ and pm‐cAMP, while PDE4D alone can modulate LD‐cAMP. ISO stimulation: •Ins/PDE3B has minimal impact on cyt‐cAMP.
Johannes Krier, David Spähn, David Arturo Juarez Lopez, Judith L. Nono, Judith Seigner, Lisa Jacob, Siegfried Ussar, Robert Lukowski, Andreas L. Birkenfeld, Gencer Sancar   +9 more
wiley   +1 more source

ZDHHC7-Mediated S-Palmitoylation of Scribble Regulates Cell Polarity

, 2017
Scribble (SCRIB) is a tumor suppressor protein, playing critical roles in establishing and maintaining epithelial cell polarity. Paradoxically, SCRIB is frequently amplified in human cancers, however, fails to localize properly to cell-cell junctions ...
Fu, Jianjun, Zheng, Baohui, DeRan, Micael, Wu, Xu, Chen, Baoen, Jarugumilli, Gopala, Brooks, Yang S.   +6 more
core   +1 more source

Protein cysteine palmitoylation in immunity and inflammation

, 2021
Protein cysteine palmitoylation, or S-palmitoylation, has been known for about 40 years and thousands for proteins in humans are known to be modified.
Lin, Hening, Hening Lin
core   +1 more source