Results 21 to 30 of about 20,725 (233)
From lipid modification to cell death: the diverse roles of S-palmitoylation in cell fate decisions. [PDF]
Cell Commun SignalS-palmitoylation is a dynamic, reversible lipid modification that plays a crucial role in the regulation of various types of cell death. However, systematic insights into how S-palmitoylation modifications integrate and mediate crosstalk among diverse ...
Zhu Y +5 more
europepmc +2 more sources
The role of protein palmitoylation in disease pathogenesis and therapeutic innovation. [PDF]
Ann MedBackground Protein palmitoylation is a significant post-translational modification that influences protein stability, localization, and signaling through the addition of palmitoyl groups to cysteine, serine/threonine, or lysine residues.
Lin X +7 more
europepmc +2 more sources
Post-translational palmitoylation of metabolic proteins
Frontiers in Physiology, 2023 Numerous cellular proteins are post-translationally modified by addition of a lipid group to their structure, which dynamically influences the proteome by increasing hydrophobicity of proteins often impacting protein conformation, localization, stability,
Kaitlyn M. J. H. Dennis, Lisa C. Heather
doaj +3 more sources
Palmitoylation-dependent regulation of GPX4 suppresses ferroptosis
Nature CommunicationsS-palmitoylation is a reversible and widespread post-translational modification, but its role in the regulation of ferroptosis has been poorly understood. Here, we elucidate that GPX4, an essential regulator of ferroptosis, is reversibly palmitoylated on
Bin Huang +10 more
doaj +2 more sources
PLoS ONE, 2011 Protease-activated receptor-2 (PAR2) is a G protein coupled receptor (GPCR) activated by proteolytic cleavage of its amino terminal domain by trypsin-like serine proteases. This irreversible activation mechanism leads to rapid receptor desensitization by
Mark N Adams +4 more
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Role of Palmitoylation of Postsynaptic Proteins in Promoting Synaptic Plasticity [PDF]
Frontiers in Molecular Neuroscience, 2019 Many postsynaptic proteins undergo palmitoylation, the reversible attachment of the fatty acid palmitate to cysteine residues, which influences trafficking, localization, and protein interaction dynamics.
Lucas Matt +3 more
doaj +2 more sources
Palmitoylation as a Functional Regulator of Neurotransmitter Receptors
Neural Plasticity, 2018 The majority of neuronal proteins involved in cellular signaling undergo different posttranslational modifications significantly affecting their functions.
Vladimir S. Naumenko, Evgeni Ponimaskin
doaj +2 more sources
Palmitoylation-Dependent Small-Molecule Fluorescent Probes for Live-Cell Golgi Imaging
, 2023 Small-molecule fluorescent probes enabling visualization of the Golgi apparatus in living cells are essential tools for studying Golgi-associated biological processes and diseases.
Emi Mishiro-Sato (14426149) +13 more
core +3 more sources
Cell Death and Disease, 2022 The dynamics of synaptic vesicles (SVs) within presynaptic domains are tightly controlled by synapsin1 phosphorylation; however, the mechanism underlying the anchoring of synapsin1 with F-actin or SVs is not yet fully understood. Here, we found that Syn1
Peipei Yan +14 more
doaj +1 more source
Frontiers in Physiology, 2022 S-palmitoylation is an essential lipid modification catalysed by zDHHC-palmitoyl acyltransferases that regulates the localisation and activity of substrates in every class of protein and tissue investigated to date.
Alice Main +11 more
doaj +1 more source