Results 11 to 20 of about 22,512 (211)

Palmitoylation and depalmitoylation defects [PDF]

Journal of Inherited Metabolic Disease, 2014
AbstractPalmitoylation describes the enzymatic attachment of a 16‐carbon atom fatty acid to a target protein. Such lipidation events occur in all eukaryotes and can be of reversible (S‐palmitoylation) or irreversible (N‐palmitoylation) nature. In particular S‐palmitoylation is dynamically regulated by two opposing types of enzymes which add (palmitoyl ...
Hornemann, Thorsten, Thorsten Hornemann
openaire   +6 more sources

Insulin regulates lymphatic endothelial integrity via palmitoylation

Journal of Lipid Research
Lipid metabolism plays a critical role in lymphatic endothelial cell (LEC) development and vessel maintenance. Altered lipid metabolism is associated with loss of lymphatic vessel integrity, which compromises organ function, protective immunity, and ...
Silvia Gonzalez-Nieves, Xiaochao Wei, Simon Guignard, Thi Nguyen, Jay McQuillan, Qiang Zhang, Jinsong Zhang, Reagan M. McGuffee, David A. Ford, Clay F. Semenkovich, Vincenza Cifarelli   +10 more
doaj   +2 more sources

Post-translational palmitoylation of metabolic proteins [PDF]

Frontiers in Physiology, 2023
Numerous cellular proteins are post-translationally modified by addition of a lipid group to their structure, which dynamically influences the proteome by increasing hydrophobicity of proteins often impacting protein conformation, localization, stability,
Kaitlyn M. J. H. Dennis, Lisa C. Heather
doaj   +2 more sources

Lyssavirus Nucleoprotein Induces GPAT4-Mediated CYB5R1 Depalmitoylation to Suppress Ferroptosis and Promote Viral Replication. [PDF]

Adv Sci (Weinh)
Lipid metabolism plays a vital role in viral infections. Here, we reveal that the lyssavirus N protein regulates GPAT4 to induce lipid droplet biogenesis, restricting CYB5R1 palmitoylation and reducing ferroptosis susceptibility to ultimately promote viral replication.
Zhao J, Liang C, Chen P, Sun M, Fu ZF, Zhao L, Zhou M.   +6 more
europepmc   +2 more sources

Palmitoyl Acyltransferase Zdhhc17 Promotes Functional Recovery After Spinal Cord Injury by Targeting the Nuclear Transport Factors Kpna2 and Ipo9. [PDF]

Adv Sci (Weinh)
In this study, we demonstrate that Zdhhc17, acting as a PAT, suppresses neuronal apoptosis and promotes axon regeneration after injury, thereby enhancing functional recovery following SCI. In this context, Kpna2 and Ipo9 serve as novel palmitoylation substrates of Zdhhc17, whose palmitoylation prevents the injury‐induced degradation of their proteins ...
Chen M, Chen H, Ding S, Liu F, Zheng X, Wang Y, Tian R, Li H, Liu P, Hu L, Liu B, Rong L, Li M.   +12 more
europepmc   +2 more sources

Palmitoylation-dependent regulation of innate and adaptive immunity: molecular insights and translational opportunities [PDF]

Cellular & Molecular Biology Letters
Immune cells orchestrate organismal defense through pathogen surveillance, tissue homeostasis, and immune tolerance, with innate and adaptive subsets coordinating context-specific responses.
Binhui Zhou, Bowen Zhang, Yingcheng Qi, Sainan Li, Tingting Liu, Tong Li, Ying Wang, Haifeng Wang, Jiaqi Lu, Fei Cao, Xiaohong Kang, Eryan Kong, Yinming Liang   +12 more
doaj   +2 more sources

Palmitoylation of PSD-95 Orchestrates Learning-Dependent Metaplasticity in the Amygdala and Fear Memory. [PDF]

Adv Sci (Weinh)
This study reveals that fear learning specifically triggers PICK1/DHHC2‐dependent palmitoylation of PSD‐95 in the lateral amygdala. Fear conditioning induces the dissociation of DHHC5 from PSD‐95 and the association of PSD‐95 with DHHC2. DHHC2‐mediated palmitoylation of PSD‐95 is required for synaptic transmission and underlies fear learning–induced ...
Shen ZC, Weng YX, Xia ZX, Zhao YL, Ding QQ, Wang SY, Cao T, Chen XY, Tao WC, Lin S, Chen Z, Luo YX.   +11 more
europepmc   +2 more sources

Palmitoylation-dependent regulation of GPX4 suppresses ferroptosis

Nature Communications
S-palmitoylation is a reversible and widespread post-translational modification, but its role in the regulation of ferroptosis has been poorly understood. Here, we elucidate that GPX4, an essential regulator of ferroptosis, is reversibly palmitoylated on
Bin Huang, Hui Wang, Shuo Liu, Meng Hao, Dan Luo, Yi Zhou, Ying Huang, Yong Nian, Lei Zhang, Bo Chu, Chengqian Yin   +10 more
doaj   +2 more sources

Palmitoylation-Dependent Small-Molecule Fluorescent Probes for Live-Cell Golgi Imaging

, 2023
Small-molecule fluorescent probes enabling visualization of the Golgi apparatus in living cells are essential tools for studying Golgi-associated biological processes and diseases.
Emi Mishiro-Sato (14426149), Shunsuke Sawada, Keiko Kano (493477), Masaru Yoshikawa (10691876), Masaru Yoshikawa, Emi Mishiro-Sato, Keita Tsutsui (15354549), Keiko Kano, Shinya Tsukiji, Shinya Tsukiji (1919149), Shunsuke Sawada (5982365), Keita Tsutsui, Tomoki Miyazaki (15354552), Tomoki Miyazaki   +13 more
core   +3 more sources

Adipocyte-Derived Palmitic Acid Promotes Breast Cancer Malignancy via ZDHHC15-Mediated S-Palmitoylation of PPARγ. [PDF]

Cancer Sci
Adipocyte‐derived palmitic acid induces ZDHHC15‐mediated PPARγ S‐palmitoylation at Cys159, triggering its proteasomal degradation and promoting breast cancer malignancy with rosiglitazone resistance. Inhibition of PPARγ S‐palmitoylation by 2‐bromopalmitate suppresses breast cancer progression and synergistically enhances rosiglitazone efficacy ...
Moon GH, Lee MY, Koh J, Hong KY, Fukuda J, Kim SJ, Chun YS.   +6 more
europepmc   +2 more sources