Results 41 to 50 of about 60,893 (292)
Versatility of Acyl-Acyl Carrier Protein Synthetases
Chemistry & Biology, 2014 The acyl carrier protein (ACP) requires posttranslational modification with a 4'-phosphopantetheine arm for activity, and this thiol-terminated modification carries cargo between enzymes in ACP-dependent metabolic pathways. We show that acyl-ACP synthetases (AasSs) from different organisms are able to load even, odd, and unnatural fatty acids onto E ...
Beld, Joris +2 more
openaire +2 more sources
, 2008 The substrate recognition of Candida antarctica lipase B (CAL-B) in the acylation of nucleosides was revealed through rational substrate engineering for the first time. CAL-B displayed lower activities and excellent 5'-regioselectivities (94 to >99 %) in
Li, Ning +4 more
core +1 more source
Calcium‐Mechanochemistry Enabled Ketone Synthesis From Organic Iodides and Carboxylic Acids
Advanced Science, EarlyView.Mechanochemically generated organocalcium species display unusual chemoselectivity toward carboxylates, enabling direct ketone synthesis without overaddition. Ball milling activates commercial calcium metal under ambient, solvent‐minimized conditions, providing a broad substrate scope, high functional‐group tolerance, and a practical one‐step ...
Mengyao Pei +9 more
wiley +1 more source
Noncanonical Peloruside A Biosynthesis by an Uncultivated Verrucomicrobiota Symbiont
Angewandte Chemie, EarlyView.Noncanonical biochemistry of the peloruside PKS characterized in this work, comprising double bond generation by a noncanonical tridomain (blue), acetyl‐CoA recycling (orange), and proofreading systems (purple and yellow). The Z‐double bond is installed by TEB1 through O‐acetylation and acetate elimination. The acyl ligase PelB (AL, orange) selectively
Amy E. Fraley +11 more
wiley +2 more sources
S-acylation in plants:an expanding field [PDF]
, 2020 S-acylation is a common yet poorly understood fatty acid-based post-translational modification of proteins in all eukaryotes, including plants. While exact roles for S-acylation in protein function are largely unknown the reversibility of S-acylation ...
Hemsley, Piers A.; id_orcid
core +1 more source
Chemoselective Metabolomics via a Modular Reactivity‐Encoding Platform
Advanced Science, EarlyView.Conventional LC–MS underrepresents numerous metabolites due to heterogeneous ionization efficiencies and matrix interference. Here, we introduce a modular reactivity‐encoding platform (MREP) comprising four alkyne‐tagged probes that selectively derivatize key functional groups, followed by unified click‐chemistry capture to eliminate matrix components ...
Xin Tao +10 more
wiley +1 more source
Carbohydrate Polymer Technologies and ApplicationsThe chemistry of chitosan is a promising way to afford biobased and biodegradable complex materials using highly reactive compounds such as anhydrides. However, the potential applications are limited due to the absence of control over the acylation and ...
Paul Morandi +5 more
doaj +1 more source
Chiral isothiourea-catalyzed kinetic resolution of 4-hydroxy[2.2]paracyclophane
Beilstein Journal of Organic Chemistry, 2021 We herein report a method for the kinetic resolution of racemic 4-hydroxy[2.2]paracyclophane by means of a chiral isothiourea-catalyzed acylation with isobutyric anhydride.
David Weinzierl, Mario Waser
doaj +1 more source
Palmitoylation as a Key Regulator of Ras Localization and Function
Frontiers in Molecular Biosciences, 2021 Ras proteins require membrane association for proper function. This process is tightly regulated by reversible palmitoylation that controls not only the distribution over different subcellular compartments but also Ras compartmentalization within ...
Carla Busquets-Hernández, Gemma Triola
doaj +1 more source
Covalently Linked Peptides and Membrane Potential Enable CyaA Segment Translocation
Advanced Science, EarlyView.Using a newly developed Droplet Interface Bilayer‐Pipette assay, the authors show that two segments of the CyaA toxin cross membranes by distinct mechanisms. One segment translocates spontaneously, whereas the translocation of the other depends on membrane potential.
Gaia Scilironi +9 more
wiley +1 more source