Results 41 to 50 of about 126,317 (283)

Lysine Fatty Acylation: Regulatory Enzymes, Research Tools, and Biological Function

Frontiers in Cell and Developmental Biology, 2021
Post-translational acylation of lysine side chains is a common mechanism of protein regulation. Modification by long-chain fatty acyl groups is an understudied form of lysine acylation that has gained increasing attention recently due to the ...
Garrison Komaniecki, Hening Lin
semanticscholar   +1 more source

An ABHD17-like hydrolase screening system to identify de-S-acylation enzymes of protein substrates in plant cells.

The Plant Cell, 2021
Protein S-acylation is an important post-translational modification in eukaryotes, regulating the subcellular localization, trafficking, stability, and activity of substrate proteins.
Xiaoshi Liu, Min Li, Yang Li, Zian Chen, Chun-chun Zhuge, Youwei Ouyang, Yawen Zhao, Yuxin Lin, Qi Xie, Chengwei Yang, Jianbin Lai   +10 more
semanticscholar   +1 more source

Versatility of Acyl-Acyl Carrier Protein Synthetases

Chemistry & Biology, 2014
The acyl carrier protein (ACP) requires posttranslational modification with a 4'-phosphopantetheine arm for activity, and this thiol-terminated modification carries cargo between enzymes in ACP-dependent metabolic pathways. We show that acyl-ACP synthetases (AasSs) from different organisms are able to load even, odd, and unnatural fatty acids onto E ...
Beld, Joris, Finzel, Kara, Burkart, Michael D.   +2 more
openaire   +2 more sources

Acyl-Lipid Metabolism [PDF]

The Arabidopsis Book, 2010
Acyl lipids in Arabidopsis and all other plants have a myriad of diverse functions. These include providing the core diffusion barrier of the membranes that separates cells and subcellular organelles. This function alone involves more than 10 membrane lipid classes, including the phospholipids, galactolipids, and sphingolipids, and within each class ...
Li-Beisson, Yonghua, Shorrosh, Basil, Beisson, Fred, Andersson, Mats X., Arondel, Vincent, Bates, Philippe D., Baud, Sebastien, Bird, David, Debono, Allan, Durrett, Timithy P., Franke, Rochus B., Graham, Ian A., Katayama, Kenta, Kelly, Amelie A., Larson, Tony, Markham, Jonathan E., Miquel, Martine, Molina, Isabel, Nishida, Ikuo, Rowland, Owen, Samuels, Lacey, Schmid, Katherine M., Wada, Hajime, Welti, Ruth, Xu, Changcheng, Zallot, Rémi, Ohlrogge, John   +26 more
openaire   +6 more sources

Merging Biocatalysis and Chemocatalysis in Flow: State‐of‐the‐Art and Future Directions for Sustainable Synthesis

Angewandte Chemie, EarlyView.
This review highlights recent advances in integrating biocatalysis and chemocatalysis in continuous flow to create streamlined, sustainable processes. It examines chemo‐enzymatic cascades combining at least one enzymatic and one chemical step, discusses challenges such as enzyme immobilization, leaching, and reactor clogging, and presents solutions ...
Petros Siasiaridis, Matteo Damian, Francesco G. Mutti   +2 more
wiley   +2 more sources

Histone acylation marks respond to metabolic perturbations and enable cellular adaptation

Experimental and Molecular Medicine, 2020
Acetylation is the most studied histone acyl modification and has been recognized as a fundamental player in metabolic gene regulation, whereas other short-chain acyl modifications have only been recently identified, and little is known about their ...
Chanhee Jo, Seokjae Park, Sungjoon Oh, Jinmi Choi, Eun-Kyoung Kim, H. Youn, E. Cho   +6 more
semanticscholar   +1 more source

Proximity‐Induced Transfer of a Mass Tag Enables Direct Profiling of Active Matrix Metalloproteases

Angewandte Chemie, EarlyView.
A proximity‐induced, mass‐encoded activity‐based protein profiling (ABPP) approach transfers a MALDI‐detectable α‐cyano‐4‐hydroxycinnamic acid (CHCA) tag directly to active proteases. This tag enables the direct, multiplexed, and quantitative detection of enzyme activity in complex proteomes without enrichment or purification.
Lomane Berthy, Ugo Pasco, Mylene Sejalon‐Cipolla, Pierrick Bruyat, Monika Kaminska, Carole Malgorn, Fabrice Beau, Manca Osolin, Metka Novak, Barbara Breznik, Dimitris Georgiadis, Isabelle Correia, Emeline Groult, Olivier Lequin, Sarah Bregant, Yves‐Marie Pers, Daniele Noel, Robert Thai, Gilles Subra, Sonia Cantel, Laurent Devel   +20 more
wiley   +2 more sources

A Receptor Component of the Chloroplast Protein Translocation Machinery [PDF]

, 1994
The chloroplast outer envelope protein OEP86 functions as a receptor in precursor protein translocation into chloroplasts. Sequence analysis suggests that the precursor of OEP86 is directed to the chloroplast outer envelope by a cleavable, negatively ...
Heemeyer, Frank, Heijne, Gunnar von, Hirsch, Stephan, Muckel, Eva, Soll, Jürgen   +4 more
core   +1 more source

Chemical Metabolomics: Chemical Biology Tools for Advanced Metabolism Investigations

Angewandte Chemie, EarlyView.
The human metabolism has been investigated for several millennia. The metabolome is known for a high complexity due to a large number of different metabolites that are present at different concentrations. Metabolomics has been developed as a field to investigate the entire human metabolome and to elucidate disease development mechanisms.
Alejandro Torregrosa‐Chinillach, Ioanna Tsiara, Wawrzyniec Haberek, Weifeng Lin, Daniel Globisch   +4 more
wiley   +2 more sources

Tailoring Vascular‐Immune Homeostasis via Manganese‐DNA Complex‐Armed Immunogenic Extracellular Vesicles for Pancreatic Cancer Immunotherapy

Advanced Science, EarlyView.
This study demonstrates that Mn2⁺–tumor DNA complexes encapsulated in dendritic cell (DC)– derived immunogenic extracellular vesicles (EVDC@Mn‐DNA) act as a DC‐specific cGAS– STING activator. EVDC@Mn‐DNA treatment enhances intratumoral DC activation, improves tumor vascular function, promotes CD8⁺ T cell activity, and suppresses pancreatic tumor growth,
Xue Jiang, Lihuan Shang, Xiaochun Chen, Xiangzhan Kong, Xiaojuan Wang, Linjia Jiang, Huiying Zhao, Yafeng Zhu, Cheng Huang, Shiyi Deng, Rui Zhang, Minghui Wang, Haoming Lin, Ping‐Pui Wong   +13 more
wiley   +1 more source