Regulation of ERK2 activity by dynamic S-acylation [PDF]
Cell Reports, 2023 Summary: Extracellular signal-regulated kinases (ERK1/2) are key effector proteins of the mitogen-activated protein kinase pathway, choreographing essential processes of cellular physiology.
Saara-Anne Azizi +3 more
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Oleate activates PLD2 lipase and GEF activity by modulating membrane microdomain dynamics via S-acylation [PDF]
Journal of Lipid ResearchPhospholipase D2 (PLD2) plays critical roles in cellular signaling, membrane dynamics, and cancer progression. Oleate (OA) has been shown to activate PLD2 and promote triple-negative breast cancer (TNBC) cell migration, but the underlying molecular ...
Zhiqiang Guo +2 more
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Sequestering sequestosome 1 via S-acylation in autophagy, Huntington disease, and beyond [PDF]
Autophagy ReportsProtein mislocalization and aggregation are hallmark features in neurodegeneration. As proteins mislocalize, proteostasis deficiency and protein aggregation typically follow.
Y Alshehabi, F Abrar, D.D.O Martin
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Regulation of T cell function by protein S-acylation [PDF]
Frontiers in Physiology, 2022 S-acylation, the reversible lipidation of free cysteine residues with long-chain fatty acids, is a highly dynamic post-translational protein modification that has recently emerged as an important regulator of the T cell function. The reversible nature of
Savannah J. West +4 more
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Regulation of Dynamic Protein S-Acylation [PDF]
Frontiers in Molecular Biosciences, 2021 Protein S-acylation is the reversible addition of fatty acids to the cysteine residues of target proteins. It regulates multiple aspects of protein function, including the localization to membranes, intracellular trafficking, protein interactions ...
Jessica J. Chen +2 more
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S‐acylation of Ca2+ transport proteins in cancer [PDF]
Chronic Diseases and Translational MedicineAlterations in cellular calcium (Ca2+) signals have been causally associated with the development and progression of human cancers. Cellular Ca2+ signals are generated by channels, pumps, and exchangers that move Ca2+ ions across membranes and are ...
Sana Kouba, Nicolas Demaurex
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Improvement of plant resistance to geminiviruses via protein de-S-acylation [PDF]
Stress BiologyGeminiviruses are an important group of viruses that infect a variety of plants and result in heavy agricultural losses worldwide. The homologs of C4 (or L4) in monopartite geminiviruses and AC4 (or AL4) in bipartite geminiviruses are critical viral ...
Yawen Zhao +11 more
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S-acylation of NLRP3 provides a nigericin sensitive gating mechanism that controls access to the Golgi [PDF]
eLifeNLRP3 is an inflammasome seeding pattern recognition receptor activated in response to multiple danger signals which perturb intracellular homeostasis.
Daniel M Williams, Andrew A Peden
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C-terminal S-acylation governs membrane distribution, interaction dynamics and function of a plant Rho GTPase. [PDF]
PLoS ONERho of Plants (ROPs) are plant-specific Rho GTPases that regulate diverse cellular processes. Based on their C-terminal motifs, ROPs are classified as type I or type II.
Amir Akerman +5 more
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Dynamic S-acylation controls CMG2 maturation extracellular matrix regulation and anthrax toxin susceptibility in vivo [PDF]
Nature CommunicationsCMG2/ANTXR2 functions as a Collagen VI receptor required for extracellular matrix homeostasis and as the primary portal for anthrax toxin entry. Mutations in CMG2 cause Hyaline Fibromatosis Syndrome (HFS), a rare and often fatal genetic disorder ...
Laurence Abrami +8 more
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