Results 11 to 20 of about 21,138,684 (162)

Mechanisms and functions of protein S-acylation [PDF]

Nature Reviews Molecular Cell Biology
Over the past two decades, protein S-acylation (often referred to as S-palmitoylation) has emerged as an important regulator of vital signalling pathways. S-Acylation is a reversible post-translational modification that involves the attachment of a fatty acid to a protein.
Laurence Abrami, F S Mesquita, Gisou van der Goot   +2 more
exaly   +7 more sources

Efficient S-Acylation of Thiourea [PDF]

SynOpen, 2018
Efficient S-acylation of thiourea using a variety of acid chlorides is reported. Structurally diverse aryl and alkyl substrates are compatible with this methodology.
David J. Jones, Uday B. Rao Khandavilli, Eileen M. O’Leary, Simon E. Lawrence, Timothy P. O’Sullivan   +4 more
doaj   +5 more sources

Dynamics of CLIMP-63 S-acylation control ER morphology [PDF]

Nature Communications, 2023
A key player in the formation of endoplasmic reticulum sheets is CLIMP-63, but mechanistic details remained elusive. Here authors combined cellular experiments and mathematical modelling to show that S-acylation of CLIMP-63 regulates its function by ...
Patrick A. Sandoz, Robin A. Denhardt-Eriksson, Laurence Abrami, Luciano A. Abriata, Gard Spreemann, Catherine Maclachlan, Sylvia Ho, Béatrice Kunz, Kathryn Hess, Graham Knott, Francisco S. Mesquita, Vassily Hatzimanikatis, F. Gisou van der Goot   +12 more
doaj   +4 more sources

S-acylation in plants: an expanding field [PDF]

Biochemical Society Transactions, 2020
S-acylation is a common yet poorly understood fatty acid-based post-translational modification of proteins in all eukaryotes, including plants. While exact roles for S-acylation in protein function are largely unknown the reversibility of S-acylation indicates that it is likely able to play a regulatory role.
Hemsley, Piers A.; id_orcid
openaire   +5 more sources

Dynamic Protein S-Acylation in Plants [PDF]

International Journal of Molecular Sciences, 2019
Lipid modification is an important post-translational modification. S-acylation is unique among lipid modifications, as it is reversible and has thus attracted much attention. We summarize some proteins that have been shown experimentally to be S-acylated in plants. Two of these S-acylated proteins have been matched to the S-acyl transferase.
Lihua Zheng, Peng Liu, Qianwen Liu, Tao Wang, Jiangli Dong   +4 more
openaire   +3 more sources

Fat traffic control: S-acylation in axonal transport. [PDF]

Mol Pharmacol
Neuronal axons serve as a conduit for the coordinated transport of essential molecular cargo between structurally and functionally distinct subcellular compartments via axonal molecular machinery. Long-distance, efficient axonal transport of membrane-bound organelles enables signal transduction and neuronal homeostasis.
Doerksen AH, Herath NN, Sanders SS.
europepmc   +5 more sources

S-acylation by the DHHC protein family

Biochemical Society Transactions, 2010
A family of 23 DHHC (Asp-His-His-Cys) proteins that function as mammalian S-acyltransferases has been identified, reinvigorating the study of protein S-acylation. Recent studies have continued to reveal how S-acylation affects target proteins, and have provided glimpses of how DHHC-substrate specificity might be achieved.
Greaves, Jennifer, Chamberlain, Luke H
core   +8 more sources

The Physiology of ProteinS-acylation [PDF]

Physiological Reviews, 2015
Protein S-acylation, the only fully reversible posttranslational lipid modification of proteins, is emerging as a ubiquitous mechanism to control the properties and function of a diverse array of proteins and consequently physiological processes. S-acylation results from the enzymatic addition of long-chain lipids, most typically palmitate, onto ...
Chamberlain, Luke H., Shipston, Michael J.   +1 more
openaire   +8 more sources

Regulatory effects of protein S-acylation on insulin secretion and insulin action [PDF]

Open Biology, 2021
Post-translational modifications (PTMs) such as phosphorylation and ubiquitination are well-studied events with a recognized importance in all aspects of cellular function.
Luke H. Chamberlain, Michael J. Shipston, Gwyn W. Gould   +2 more
doaj   +4 more sources

Protein S-acylation in plants (Review)

Molecular Membrane Biology, 2009
Membrane resident proteins are a common feature of biology yet many of these proteins are not integral to the membrane. These peripheral membrane proteins are often bound to the membrane by the addition of fatty acyl chains to the protein. This modification, known as S-acylation or palmitoylation, promotes very strong membrane association but is also ...
Hemsley, Piers A; id_orcid
openaire   +4 more sources