Results 31 to 40 of about 21,138,684 (162)
Frontiers in Plant Science, 2022 Protein S-acylation, also known as palmitoylation, is an important lipid post-translational modification of proteins in eukaryotes. S-acylation plays critical roles in a variety of protein functions involved in plant development and responses to abiotic ...
Jincheng Li, Manqi Zhang, Lijuan Zhou
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The Golgi S-acylation machinery comprises zDHHC enzymes with major differences in substrate affinity and S-acylation activity [PDF]
, 2014 S-acylation, the attachment of fatty acids onto cysteine residues, regulates protein trafficking and function, and is mediated by a family of “zDHHC” enzymes.
Sanchez Perez, Maria C. +4 more
core +4 more sources
FASN inhibitor TVB-3166 prevents S-acylation of the spike protein of human coronaviruses
Journal of Lipid Research, 2022 The spike protein of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and other coronaviruses mediates host cell entry and is S-acylated on multiple phylogenetically conserved cysteine residues.
Katrina Mekhail +13 more
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The role of S‐acylation in protein trafficking [PDF]
Traffic, 2017 Protein S‐acylation, also known as palmitoylation, consists of the addition of a lipid molecule to one or more cysteine residues through a thioester bond. This modification, which is widespread in eukaryotes, is thought to affect over 12% of the human proteome.
José L. Daniotti +2 more
openaire +3 more sources
The GCP16-zDHHC9 S-acyltransferase complex: Reciprocal effects on protein S-acylation and stability. [PDF]
J Biol ChemS-Acylation is catalyzed by a family of twenty-three zinc-dependent zDHHC enzymes. A subset of these enzymes is regulated by accessory proteins, such as GCP16, which associates with the Golgi-localized acyltransferase zDHHC9 to form a functional complex.
Allagioti D +8 more
europepmc +3 more sources
S-acylation of P2K1 mediates extracellular ATP-induced immune signaling in Arabidopsis
Nature Communications, 2021 S-acylation is a reversible protein post-translational modification that often regulates protein function at the plasma membrane. Here the authors show that an Arabidopsis extracellular ATP receptor P2K1 mediates phosphorylation of two S-acyltransferases
Dongqin Chen +5 more
doaj +1 more source
eLife, 2021 Efficient immune responses require Ca2+ fluxes across ORAI1 channels during engagement of T cell receptors (TCR) at the immune synapse (IS) between T cells and antigen presenting cells. Here, we show that ZDHHC20-mediated S-acylation of the ORAI1 channel
Amado Carreras-Sureda +8 more
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Palmitoylation: A Fatty Regulator of Myocardial Electrophysiology
Frontiers in Physiology, 2020 Regulation of cardiac physiology is well known to occur through the action of kinases that reversibly phosphorylate ion channels, calcium handling machinery, and signaling effectors.
Kobina Essandoh +5 more
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Cleaner Routes for Friedel-Crafts Acylation [PDF]
, 2010 Friedel-Crafts acylation is among the most fundamental and useful reactions to yield aromatic ketones but it is one of the less acceptable in terms of unwanted polluting by-products or atom economy because of the overconsumption of catalyst which is used
Aribert, Nicolas +4 more
core +1 more source
Site-specific analysis of protein S-acylation by resin-assisted capture[S]
Journal of Lipid Research, 2011 Protein S-acylation is a major posttranslational modification whereby a cysteine thiol is converted to a thioester. A prototype is S-palmitoylation (fatty acylation), in which a protein undergoes acylation with a hydrophobic 16 carbon lipid chain ...
Michael T. Forrester +6 more
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