Results 21 to 30 of about 60,893 (292)
The effect of acylation with fatty acids and other modifications on HLA class II:peptide binding and T cell stimulation for three model peptides. [PDF]
PLoS ONE, 2018 Immunogenicity is a major concern in drug development as anti-drug antibodies in many cases affect both patient safety and drug efficacy. Another concern is often the limited half-life of drugs, which can be altered by different chemical modifications ...
Heidi S Schultz +4 more
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Cycvalone in the synthesis of nitrogen-, oxygen-containing heterocycles [PDF]
Известия Саратовского университета. Новая серия: Серия Химия. Биология. Экология, 2023 Cycvalone is an analogue of curcumin (EE conformation), exhibits a wide range of biological activity (antioxidant, hepatoprotective, membrane stabilizing, anti-ulcer) and is used in medical practice as a choleretic.
Rogov, Danila A. +1 more
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, 2023 Acylation reaction belongs to the most desired transformation by chemists because of its wide application for industrial scale synthesis of fine chemicals and pharmaceuticals.
Mannepalli, Lakshmi Kantam +4 more
core +1 more source
Regulation of ERK2 activity by dynamic S-acylation
Cell Reports, 2023 Summary: Extracellular signal-regulated kinases (ERK1/2) are key effector proteins of the mitogen-activated protein kinase pathway, choreographing essential processes of cellular physiology.
Saara-Anne Azizi +3 more
doaj +1 more source
The physiology of protein S-acylation [PDF]
, 2015 Protein S-acylation, the only fully reversible posttranslational lipid modification of proteins, is emerging as a ubiquitous mechanism to control the properties and function of a diverse array of proteins and consequently physiological processes.
Chamberlain, Luke H. +1 more
core +5 more sources
Discovery of Anthocyanin Acyltransferase1 (AAT1) in Maize Using Genotyping-by-Sequencing (GBS)
G3: Genes, Genomes, Genetics, 2018 The reduced acylation phenotype describes the inability of certain accessions of maize (Zea mays [L.]) to produce significant amounts of acylated anthocyanins, which are typically the most abundant pigments.
Michael N. Paulsmeyer +2 more
doaj +1 more source
eLife, 2021 Efficient immune responses require Ca2+ fluxes across ORAI1 channels during engagement of T cell receptors (TCR) at the immune synapse (IS) between T cells and antigen presenting cells. Here, we show that ZDHHC20-mediated S-acylation of the ORAI1 channel
Amado Carreras-Sureda +8 more
doaj +1 more source
Nickel-Catalyzed Acylation of Aryl Bromides with Acyl Imidazoles [PDF]
, 2019 Alkyl imidazolides were herein found to be viable coupling partners for the Ni-catalyzed acylation of aryl bromides. This cross-coupling reaction features a broad substrate scope and be performed in an extremely cost-efficient fashion.
Zijian Li (6948099) +7 more
core +2 more sources
Research Progress on Acylation Modification and Application of Animal and Vegetable Proteins [PDF]
Shipin KexueAcylation is a common method for chemical modification of proteins, which can effectively improve the functional properties of proteins and has been widely used in food processing in recent years.
YAO Xuan, LÜ Xiaohui, JIN Yongguo, HU Gan
doaj +1 more source
eLife, 2021 Protein acylation is critical for many cellular functions across all domains of life. In bacteria, lipoproteins have important roles in virulence and are targets for the development of antimicrobials and vaccines. Bacterial lipoproteins are secreted from
Christopher Icke +7 more
doaj +1 more source