Lipidated peptides and the limits of chemical control [PDF]
Frontiers in ChemistryPeptide lipidation is widely employed to enhance the apparent biological performance of peptide-based systems by improving stability, membrane association, and systemic persistence. However, increased potency is often interpreted uncritically as evidence
Cesar Augusto Roque-Borda +6 more
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The Emerging Roles of Protein Lipidation in Fertility and Reproductive Disorders: Mechanisms and Therapeutic Implications [PDF]
BiomoleculesProtein lipidation, a pivotal post-translational modification, dynamically regulates cellular signaling, membrane trafficking, and protein stability, with emerging roles in reproductive physiology.
Heran Cao +6 more
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Seipin expression in hepatocytes impairs the assembly of VLDLs and exacerbates steatohepatitis [PDF]
Journal of Lipid ResearchVLDLs are crucial for maintaining liver and whole-body lipid homeostasis. Limited knowledge exists regarding the lipidation process of VLDL. Endoplasmic reticulum (ER) luminal lipid droplets (LLDs) have been suggested to provide lipids for VLDL ...
Qianqian Dong +13 more
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Glycosylation and Lipidation Strategies: Approaches for Improving Antimicrobial Peptide Efficacy
Pharmaceuticals, 2023 Antimicrobial peptides (AMPs) have recently gained attention as a viable solution for combatting antibiotic resistance due to their numerous advantages, including their broad-spectrum activity, low propensity for inducing resistance, and low cytotoxicity.
Annarita Falanga +2 more
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Lipidation as a post-translational code for protein liquid-liquid phase separation [PDF]
Journal of Lipid ResearchLiquid–liquid phase separation has emerged as a central organizing mechanism that drives the formation of biomolecular condensates and enables cells to spatially and temporally coordinate metabolism, signaling, and gene expression. While the influence of
Soodabeh Abbasi Sani +2 more
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Protein Lipidation by Palmitoylation and Myristoylation in Cancer
Frontiers in Cell and Developmental Biology, 2021 Posttranslational modification of proteins with lipid moieties is known as protein lipidation. The attachment of a lipid molecule to proteins endows distinct properties, which affect their hydrophobicity, structural stability, localization, trafficking ...
Azhar Ali, Ali Azhar
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Protein lipidation in the tumor microenvironment: enzymology, signaling pathways, and therapeutics [PDF]
Molecular CancerProtein lipidation is a pivotal post-translational modification that increases protein hydrophobicity and influences their function, localization, and interaction network.
Mengke Xu, Bo Xu
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Uncovering the prevalence, key biogenesis enzymes, and biological significance of archaeal lipoproteins [PDF]
Nature CommunicationsLipid-anchored proteins are integral components of cell surfaces. In bacteria, lipidation of proteins with a conserved lipobox motif ([L/V/I]−3 [A/S/T/V/I]−2 [G/A/S]−1 [C]+1) is catalyzed by prolipoprotein diacylglyceryl transferase (Lgt).
Yirui Hong +6 more
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Lipid A and Anti-Lipid A [PDF]
Infection and Immunity, 1979 Lipid A in free form, in crude antigen preparations, and on Formalin-treated Escherichia coli and Salmonella minnesota R595 was employed in studies of its antigenic composition, immunogenicity, and availability on gram-negative bacteria.
I, Mattsby-Baltzer, B, Kaijser
openaire +2 more sources
APOE and Alzheimer’s Disease: From Lipid Transport to Physiopathology and Therapeutics
Frontiers in Neuroscience, 2021 Alzheimer’s disease (AD) is a devastating neurodegenerative disorder characterized by extracellular amyloid β (Aβ) and intraneuronal tau protein aggregations.
Mohammed Amir Husain +5 more
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