Lipidated peptides and the limits of chemical control [PDF]
Frontiers in ChemistryPeptide lipidation is widely employed to enhance the apparent biological performance of peptide-based systems by improving stability, membrane association, and systemic persistence. However, increased potency is often interpreted uncritically as evidence
Cesar Augusto Roque-Borda +6 more
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Enzyme-centric chemoproteomics reveals isomer-specific S-acylation modification networks [PDF]
Nature CommunicationsProtein lipidation is a critical post-translational modification, but the relationship between the fine structure of fatty acids (FAs) and the specificity of lipidation remains largely unexplored.
Pengfei Wu +6 more
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The Emerging Roles of Protein Lipidation in Fertility and Reproductive Disorders: Mechanisms and Therapeutic Implications [PDF]
BiomoleculesProtein lipidation, a pivotal post-translational modification, dynamically regulates cellular signaling, membrane trafficking, and protein stability, with emerging roles in reproductive physiology.
Heran Cao +6 more
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Glycosylation and Lipidation Strategies: Approaches for Improving Antimicrobial Peptide Efficacy
Pharmaceuticals, 2023 Antimicrobial peptides (AMPs) have recently gained attention as a viable solution for combatting antibiotic resistance due to their numerous advantages, including their broad-spectrum activity, low propensity for inducing resistance, and low cytotoxicity.
Annarita Falanga +2 more
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Lipidation of small GTPase Cdc42 as regulator of its physiological and pathophysiological functions
Frontiers in Physiology, 2023 The protein cell division cycle 42 (Cdc42) is a small GTPase of the Rho family regulating a plethora of physiological functions in a tissue, cell and subcellular-specific manner via participating in multiple signaling pathways.
Alexander Wirth, Evgeni Ponimaskin
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Structural Dynamics of GLP-1 Analogues: Folding Energetics, Lipidation-Driven Assembly, and Aggregation Mechanisms [PDF]
MoleculesGlucagon-like peptide-1 (GLP-1) analogues are a major class of peptide therapeutics used to treat metabolic diseases. GLP-1-derived peptides are characterized by dynamic conformational ensembles in which folding, intermolecular assembly, and aggregation ...
Angelo Santoro +3 more
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Protein Lipidation by Palmitoylation and Myristoylation in Cancer
Frontiers in Cell and Developmental Biology, 2021 Posttranslational modification of proteins with lipid moieties is known as protein lipidation. The attachment of a lipid molecule to proteins endows distinct properties, which affect their hydrophobicity, structural stability, localization, trafficking ...
Azhar Ali
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Seipin expression in hepatocytes impairs the assembly of VLDLs and exacerbates steatohepatitis [PDF]
Journal of Lipid ResearchVLDLs are crucial for maintaining liver and whole-body lipid homeostasis. Limited knowledge exists regarding the lipidation process of VLDL. Endoplasmic reticulum (ER) luminal lipid droplets (LLDs) have been suggested to provide lipids for VLDL ...
Qianqian Dong +13 more
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Lipidation as a post-translational code for protein liquid-liquid phase separation [PDF]
Journal of Lipid ResearchLiquid–liquid phase separation has emerged as a central organizing mechanism that drives the formation of biomolecular condensates and enables cells to spatially and temporally coordinate metabolism, signaling, and gene expression. While the influence of
Soodabeh Abbasi Sani +2 more
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APOE and Alzheimer’s Disease: From Lipid Transport to Physiopathology and Therapeutics
Frontiers in Neuroscience, 2021 Alzheimer’s disease (AD) is a devastating neurodegenerative disorder characterized by extracellular amyloid β (Aβ) and intraneuronal tau protein aggregations.
Mohammed Amir Husain +5 more
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