Results 41 to 50 of about 17,356 (288)

Protein Lipidation As a Regulator of Apoptotic Calcium Release: Relevance to Cancer

Frontiers in Oncology, 2017
Calcium is a critical regulator of cell death pathways. One of the most proximal events leading to cell death is activation of plasma membrane and endoplasmic reticulum-resident calcium channels.
Jessica J. Chen, Darren Boehning
doaj   +1 more source

Peptide lipidation stabilizes structure to enhance biological function.

, 2013
Medicines that decrease body weight and restore nutrient tolerance could improve human diabetes and obesity treatment outcomes. We developed lipid-acylated glucagon analogs that are co-agonists for the glucagon and glucagon-like peptide 1 receptors, and ...
Ottaway, N.L., Ma, D., Ward, B.P., Tschöp, M.H., DiMarchi, R.D., Gelfanov, V.M., Perez-Tilve, D.   +6 more
core   +1 more source

The influence of cholesterol on melittin lipidation in neutral membranes [PDF]

, 2018
The effects of cholesterol on the process of intrinsic lipidation, whereby an acyl chain is transferred from a lipid as donor to a membrane-associated acceptor molecule, have been explored using melittin as the acceptor.
Britt, HM, Mosely, Jackie A.; id_orcid, Mosely, JA, Sanderson, JM, Sanderson, John M., Britt, Hannah M., Mosely, Jackie A.   +6 more
core   +1 more source

Non-autophagic Golgi-LC3 lipidation facilitates TFE3 stress response against Golgi dysfunction

The EMBO Journal
Lipidated ATG8/LC3 proteins are recruited to single membrane compartments as well as autophagosomes, supporting their functions. Although recent studies have shown that Golgi-LC3 lipidation follows Golgi damage, its molecular mechanism and function under
Jaemin Kang, Cathena Meiling Li, Namhoon Kim, Jongyeon Baek, Yong-Keun Jung   +4 more
doaj   +1 more source

Lipidation of pneumococcal proteins enables activation of human antigen-presenting cells and initiation of an adaptive immune response

Frontiers in Immunology
Streptococcus pneumoniae remains a significant global threat, with existing vaccines having important limitations such as restricted serotype coverage and high manufacturing costs.
Antje D. Paulikat, Dominik Schwudke, Dominik Schwudke, Dominik Schwudke, Sven Hammerschmidt, Franziska Voß   +5 more
doaj   +1 more source

Lipo-oxytocin-1, a Novel Oxytocin Analog Conjugated with Two Palmitoyl Groups, Has Long-Lasting Effects on Anxiety-Related Behavior and Social Avoidance in CD157 Knockout Mice

Brain Sciences, 2015
Oxytocin (OT) is a nonapeptide hormone that is secreted into the brain and blood circulation. OT has not only classical neurohormonal roles in uterine contraction and milk ejection during the reproductive phase in females, but has also been shown to have
Akira Mizuno, Stanislav M. Cherepanov, Yusuke Kikuchi, Azam AKM Fakhrul, Shirin Akther, Kisaburo Deguchi, Toru Yoshihara, Katsuhiko Ishihara, Satoshi Shuto, Haruhiro Higashida   +9 more
doaj   +1 more source

Regulation of ERK2 activity by dynamic S-acylation

Cell Reports, 2023
Summary: Extracellular signal-regulated kinases (ERK1/2) are key effector proteins of the mitogen-activated protein kinase pathway, choreographing essential processes of cellular physiology.
Saara-Anne Azizi, Tian Qiu, Noah E. Brookes, Bryan C. Dickinson   +3 more
doaj   +1 more source

V-ATPase and osmotic imbalances activate endolysosomal LC3 lipidation

, 2015
Recently a noncanonical activity of autophagy proteins has been discovered that targets lipidation of microtubule-associated protein 1 light chain 3 (LC3) onto macroendocytic vacuoles, including macropinosomes, phagosomes, and entotic vacuoles.
Xuejun Jiang (80217), Noor Gammoh (660882), Michael Overholtzer (660883), Sung Eun Kim (215879), Oliver Florey (660881)   +4 more
core   +1 more source

Safety of Daprodustat for the Treatment of Chronic Kidney Disease Anemia: Final Analysis of a Multicenter Postmarketing Surveillance Study in Japan

Therapeutic Apheresis and Dialysis, EarlyView.
ABSTRACT Introduction This final analysis of a multicenter, prospective postmarketing surveillance study evaluated the safety of daprodustat in patients with chronic kidney disease anemia in routine clinical practice in Japan. Methods Patients who initiated daprodustat between September 2020 and July 2022 were registered.
Tadao Akizawa, Kyomi Kanaya, Kiyomi Aizawa, Masanori Onoki, Hirofumi Ozeki, Kazuko Suzuki, Ai Hayashi, Tomohiko Asamura   +7 more
wiley   +1 more source

Association Between Individualized Education for Kidney Replacement Therapy Modality Selection and Peritoneal Dialysis Initiation: A Cross‐Sectional Study

Therapeutic Apheresis and Dialysis, EarlyView.
ABSTRACT Introduction Peritoneal dialysis (PD) is an established home‐based kidney replacement therapy (KRT), but its uptake remains low in Japan. We evaluated whether individualized education in a dedicated outpatient clinic was associated with the initiation of PD.
Yasuko Ito, Ryuichi Yoshimura, Takaki Yamauchi, Yuta Funakoshi, Hirotaka Sonoda, Seiji Kobayashi, Hiroyuki Terawaki, Takafumi Ito   +7 more
wiley   +1 more source