Results 21 to 30 of about 17,356 (288)

Inducin Triggers LC3‐Lipidation and ESCRT‐Mediated Lysosomal Membrane Repair

, 2023
: Lipidation of the LC3 protein has frequently been employed as a marker of autophagy. However, LC3-lipidation is also triggered by stimuli not related to canonical autophagy.
Corkery, D., Wu, Yao-Wen,, Axel Pahl, Ziegler, S., Sandra Koska, Slava Ziegler, Yaowen Wu, Grigalunas, Michael, Waldmann, Herbert,, Oliva, Rosario,, Belén Lucas, Kriegler, S., Oliva, R., Kriegler, Simon, Dec, Robert, Winter, Roland, Wu, Y., Lucas, B., Dale Corkery, Koska, Sandra, Waldmann, H., Kriegler, Simon,, Koska, S., Ursu, Andrei,, Grigalunas, Michael,, Sonja Sievers, Pahl, Axel, Corkery, Dale,, Koska, Sandra,, Winter, R., Sievers, Sonja,, Dec, Robert,, Simon Kriegler, Sievers, Sonja, Michael Grigalunas, Waldmann, Herbert, Pahl, A., Robert Dec, Herbert Waldmann, Pahl, Axel,, Sievers, S., Yao‐Wen Wu, Roland Winter, Winter, Roland,, Grigalunas, M., Ziegler, Slava,, Oliva, Rosario, Lucas, Belén,, Ursu, Andrei, Ursu, A., Andrei Ursu, Lucas, Belén, Ziegler, Slava, Rosario Oliva, Corkery, Dale, Dec, R., Wu, Yao-Wen   +56 more
core   +1 more source

Site-specific functionality and tryptophan mimicry of lipidation in tetraspanin CD9 [PDF]

, 2020
Lipidation of transmembrane proteins regulates many cellular activities, including signal transduction, cell-cell communication, and membrane trafficking.
Heck, Albert J R, Neviani, Viviana, Xenaki, Katerina T, Granneman, Joke, van Deventer, Sjoerd, Huisman, Sofie, Rodenburg, Remco N P, Gros, Piet, Wortel, Inge M N, van Spriel, Annemiek B, Kuiper, Jeroen K, van Bergen En Henegouwen, Paul M P, Wörner, Tobias P, van de Waterbeemd, Michiel   +13 more
core   +5 more sources

E1-Like Activating Enzyme Atg7 Is Preferentially Sequestered into p62 Aggregates via Its Interaction with LC3-I [PDF]

, 2013
p62 is constitutively degraded by autophagy via its interaction with LC3. However, the interaction of p62 with LC3 species in the context of the LC3 lipidation process is not specified.
Wang, W, Chen, Z, Gao Wentao, Wang, Wei, Gao, Wentao, Zhixia Chen, Wentao Gao, Wang Wei, Stang Michael T., Michael T Stang, Chen, Zhixia, Michael T. Stang, Gao, W, Wei Wang, Stang, MT, Stang, Michael T., Zhu, Wei-Guo, Chen Zhixia   +17 more
core   +2 more sources

Canonical and non-canonical roles for ATG8 proteins in autophagy and beyond

Frontiers in Molecular Biosciences, 2022
During autophagy, the ATG8 family proteins have several well-characterized roles in facilitating early, mid, and late steps of autophagy, including autophagosome expansion, cargo recruitment and autophagosome-lysosome fusion.
Steven Edward Reid, Srinivasa Prasad Kolapalli, Thorbjørn M. Nielsen, Lisa B. Frankel, Lisa B. Frankel   +4 more
doaj   +1 more source

Lipid Simulations: A Perspective on Lipids in Action [PDF]

Cold Spring Harbor Perspectives in Biology, 2011
In this article, we provide an overview of lipid simulations, describing how a computer can be used as a laboratory for lipid research. We briefly discuss the methodology of lipid simulations followed by a number of topical applications that show the benefit of computer modeling for complementing experiments. In particular, we show examples of cases in
Vattulainen Ilpo, Rog Thomasz
openaire   +2 more sources

Lipoprotein biosynthesis: Examination of the lipidation process

, 2001
Lipoproteins, protein-lipid complexes that have a polar exterior and a non-polar interior, have been found in many vertebrate and insect species, and their basic structure and function appear to be conserved.
Karnas, Kimberly Joy
core   +4 more sources

Phosphatidylinositol 3-kinase and COPII generate LC3 lipidation vesicles from the ER-Golgi intermediate compartment

eLife, 2014
Formation of the autophagosome requires significant membrane input from cellular organelles. However, no direct evidence has been developed to link autophagic factors and the mobilization of membranes to generate the phagophore.
Liang Ge, Min Zhang, Randy Schekman
doaj   +1 more source

Serum amyloid A is not incorporated into HDL during HDL biogenesis[S]

Journal of Lipid Research, 2020
Liver-derived serum amyloid A (SAA) is present in plasma where it is mainly associated with HDL and from which it is cleared more rapidly than are the other major HDL-associated apolipoproteins.
Ailing Ji, Xuebing Wang, Victoria P. Noffsinger, Drew Jennings, Maria C. de Beer, Frederick C. de Beer, Lisa R. Tannock, Nancy R. Webb   +7 more
doaj   +1 more source

Fluorescent imaging of protein myristoylation during cellular differentiation and development

Journal of Lipid Research, 2017
Protein post-translational modifications (PTMs) serve to give proteins new cellular functions and can influence spatial distribution and enzymatic activity, greatly enriching the complexity of the proteome.
Andrew J. Witten, Karin F.K. Ejendal, Lindsey M. Gengelbach, Meghan A. Traore, Xu Wang, David M. Umulis, Sarah Calve, Tamara L. Kinzer-Ursem   +7 more
doaj   +1 more source

An in Silico Approach to Reveal the Nanodisc Formulation of Doxorubicin

Frontiers in Bioengineering and Biotechnology, 2022
Molecular dynamic behaviors of nanodisc (ND) formulations of free doxorubicin (DOX) and DOX conjugated lipid prodrug molecules were investigated by molecular dynamics (MD) simulations.
Daiyun Xu, Xu Chen, Zhidong Chen, Yonghui Lv, Yongxiao Li, Shengbin Li, Wanting Xu, Yuan Mo, Xinpei Wang, Zirui Chen, Tingyi Chen, Tianqi Wang, Zhe Wang, Meiying Wu, Junqing Wang   +14 more
doaj   +1 more source