Results 11 to 20 of about 14,841 (259)
Lipid and Lipidation in Membrane Fusion
The Journal of Membrane Biology, 2022 Membrane fusion plays a lead role in the transport of vesicles, neurotransmission, mitochondrial dynamics, and viral infection. There are fusion proteins that catalyze and regulate the fusion. Interestingly, various types of fusion proteins are present in nature and they possess diverse mechanisms of action.
Avijit Sardar +4 more
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Post-translational Modifications of the Protein Termini
Frontiers in Cell and Developmental Biology, 2021 Post-translational modifications (PTM) involve enzyme-mediated covalent addition of functional groups to proteins during or after synthesis. These modifications greatly increase biological complexity and are responsible for orders of magnitude change ...
Li Chen, Anna Kashina
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Frontiers in Pharmacology, 2022 Signaling through calcitonin gene-related peptide (CGRP) receptors is associated with pain, migraine, and energy expenditure. Small molecule and monoclonal antibody CGRP receptor antagonists that block endogenous CGRP action are in clinical use as anti ...
Aqfan Jamaluddin +13 more
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Lipidation of small GTPase Cdc42 as regulator of its physiological and pathophysiological functions
Frontiers in Physiology, 2023 The protein cell division cycle 42 (Cdc42) is a small GTPase of the Rho family regulating a plethora of physiological functions in a tissue, cell and subcellular-specific manner via participating in multiple signaling pathways.
Alexander Wirth, Evgeni Ponimaskin
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Frontiers in Bioengineering and Biotechnology, 2021 Proteins, which have inherent biorecognition properties, have long been used as therapeutic agents for the treatment of a wide variety of clinical indications.
Calef Sánchez-Trasviña +4 more
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Lipid Simulations: A Perspective on Lipids in Action [PDF]
Cold Spring Harbor Perspectives in Biology, 2011 In this article, we provide an overview of lipid simulations, describing how a computer can be used as a laboratory for lipid research. We briefly discuss the methodology of lipid simulations followed by a number of topical applications that show the benefit of computer modeling for complementing experiments. In particular, we show examples of cases in
Vattulainen Ilpo, Rog Thomasz
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Canonical and non-canonical roles for ATG8 proteins in autophagy and beyond
Frontiers in Molecular Biosciences, 2022 During autophagy, the ATG8 family proteins have several well-characterized roles in facilitating early, mid, and late steps of autophagy, including autophagosome expansion, cargo recruitment and autophagosome-lysosome fusion.
Steven Edward Reid +4 more
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eLife, 2014 Formation of the autophagosome requires significant membrane input from cellular organelles. However, no direct evidence has been developed to link autophagic factors and the mobilization of membranes to generate the phagophore.
Liang Ge, Min Zhang, Randy Schekman
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An in Silico Approach to Reveal the Nanodisc Formulation of Doxorubicin
Frontiers in Bioengineering and Biotechnology, 2022 Molecular dynamic behaviors of nanodisc (ND) formulations of free doxorubicin (DOX) and DOX conjugated lipid prodrug molecules were investigated by molecular dynamics (MD) simulations.
Daiyun Xu +14 more
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Fluorescent imaging of protein myristoylation during cellular differentiation and development
Journal of Lipid Research, 2017 Protein post-translational modifications (PTMs) serve to give proteins new cellular functions and can influence spatial distribution and enzymatic activity, greatly enriching the complexity of the proteome.
Andrew J. Witten +7 more
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