Results 11 to 20 of about 17,356 (288)
Protein lipidation in the tumor microenvironment: enzymology, signaling pathways, and therapeutics
Molecular CancerProtein lipidation is a pivotal post-translational modification that increases protein hydrophobicity and influences their function, localization, and interaction network.
Mengke Xu, Bo Xu
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Real-Time Monitoring of ATG8 Lipidation in vitro Using Fluorescence Spectroscopy
Bio-ProtocolAutophagy is an essential catabolic pathway used to sequester and engulf cytosolic substrates via a unique double-membrane structure, called an autophagosome.
Wenxin Zhang +2 more
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A semisynthetic Atg3 reveals that acetylation promotes Atg3 membrane binding and Atg8 lipidation
Nature Communications, 2017 Acetylation of Atg3 regulates lipidation of Atg8 and therefore autophagy, but the molecular mechanisms remain unclear. Here, Liet al. semi-synthesize diacetylated Atg3, allowing them to show that acetylated Atg3 enhances Atg8 lipidation by promoting ...
Yi-Tong Li +10 more
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Acyl lipidation of a peptide: effects on activity and epidermal permeability in vitro
Drug Design, Development and Therapy, 2016 Daniel Rocco,1,2 James Ross,1,2 Paul E Murray,1 Rima Caccetta1,2 1School of Pharmacy, 2Curtin Health Innovation Research Institute, Curtin University, Perth, WA, Australia Abstract: Short-chain lipid conjugates can increase permeability of a small ...
Rocco D, Ross J, Murray PE, Caccetta R
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Subtractive CRISPR screen identifies the ATG16L1/vacuolar ATPase axis as required for non-canonical LC3 lipidation. [PDF]
, 2021 Although commonly associated with autophagosomes, LC3 can also be recruited to membranes by covalent lipidation in a variety of non-canonical contexts. These include responses to ionophores such as the M2 proton channel of influenza A virus.
Suzanne Dawn Turner (11623633) +9 more
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Lipid A and Anti-Lipid A [PDF]
Infection and Immunity, 1979 Lipid A in free form, in crude antigen preparations, and on Formalin-treated Escherichia coli and Salmonella minnesota R595 was employed in studies of its antigenic composition, immunogenicity, and availability on gram-negative bacteria.
I, Mattsby-Baltzer, B, Kaijser
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Post-translational Modifications of the Protein Termini
Frontiers in Cell and Developmental Biology, 2021 Post-translational modifications (PTM) involve enzyme-mediated covalent addition of functional groups to proteins during or after synthesis. These modifications greatly increase biological complexity and are responsible for orders of magnitude change ...
Li Chen, Anna Kashina
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Lipid and Lipidation in Membrane Fusion
The Journal of Membrane Biology, 2022 Membrane fusion plays a lead role in the transport of vesicles, neurotransmission, mitochondrial dynamics, and viral infection. There are fusion proteins that catalyze and regulate the fusion. Interestingly, various types of fusion proteins are present in nature and they possess diverse mechanisms of action.
Avijit Sardar +4 more
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Frontiers in Pharmacology, 2022 Signaling through calcitonin gene-related peptide (CGRP) receptors is associated with pain, migraine, and energy expenditure. Small molecule and monoclonal antibody CGRP receptor antagonists that block endogenous CGRP action are in clinical use as anti ...
Aqfan Jamaluddin +13 more
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Frontiers in Bioengineering and Biotechnology, 2021 Proteins, which have inherent biorecognition properties, have long been used as therapeutic agents for the treatment of a wide variety of clinical indications.
Calef Sánchez-Trasviña +4 more
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