Results 11 to 20 of about 126,317 (283)

Plasma membrane association by N-acylation governs PKG function in Toxoplasma gondii [PDF]

mBio, 2017
Cyclic GMP (cGMP)-dependent protein kinase (protein kinase G [PKG]) is essential for microneme secretion, motility, invasion, and egress in apicomplexan parasites, However, the separate roles of two isoforms of the kinase that are expressed by some ...
Brown, Kevin M, Long, Shaojun, Sibley, L. David   +2 more
core   +3 more sources

S-acylation of p62 promotes p62 droplet recruitment into autophagosomes in mammalian autophagy

Molecules and Cells, 2023
Summary p62 is a well-characterized autophagy receptor that recognizes and sequesters specific cargoes into autophagosomes for degradation. p62 promotes the assembly and removal of ubiquitinated proteins by forming p62-liquid droplets.
Xue Huang, Jia Yao, Lu Liu, Jing Chen, Ligang Mei, Jingjing Huangfu, Dong Luo, Xinyi Wang, Changhai Lin, Xiaorong Chen, Yi Yang, Ouyang Sheng, Fujing Wei, Zhuolin Wang, shao-Peng Zhang, Tingxiu Xiang, Dante Neculai, Qiming Sun, Eryan Kong, Edward W. Tate, Aimin Yang   +20 more
semanticscholar   +1 more source

Protein acylation: mechanisms, biological functions and therapeutic targets

Signal Transduction and Targeted Therapy, 2022
Metabolic reprogramming is involved in the pathogenesis of not only cancers but also neurodegenerative diseases, cardiovascular diseases, and infectious diseases.
Shuang Shang, Jing Liu, Fang Hua
semanticscholar   +1 more source

Reversible 2′-OH acylation enhances RNA stability

Nature Chemistry, 2023
Stabilization of RNAs for storage, transport and biological application remains a profound challenge. Now, it has been shown that reversible 2′-OH acylation with easily accessible acylimidazoles unlocks efficient protection of RNA. RNA can be deprotected
L. Fang, Lu Xiao, Y. Jun, Yoshiyuki Onishi, E. Kool   +4 more
semanticscholar   +1 more source

S-acylation controls SARS-CoV-2 membrane lipid organization and enhances infectivity

bioRxiv, 2021
SARS-CoV-2 virions are surrounded by a lipid bilayer which contains membrane proteins such as Spike, responsible for target-cell binding and virus fusion, the envelope protein E and the accessory protein Orf3a.
F. Mesquita, L. Abrami, O. Sergeeva, P. Turelli, Enya Qing, B. Kunz, C. Raclot, J. Paz Montoya, L. Abriata, Thomas M. Gallagher, M. dal Peraro, D. Trono, G. D’Angelo, F. G. van der Goot   +13 more
semanticscholar   +1 more source

Oncometabolites drive tumorigenesis by enhancing protein acylation: from chromosomal remodelling to nonhistone modification

Journal of experimental & clinical cancer research : CR, 2022
Metabolites are intermediate products of cellular metabolism catalysed by various enzymes. Metabolic remodelling, as a biochemical fingerprint of cancer cells, causes abnormal metabolite accumulation.
Yidian Fu, Jie Yu, Fang Li, S. Ge
semanticscholar   +1 more source

Aldehydes: magnificent acyl equivalents for direct acylation [PDF]

Organic & Biomolecular Chemistry, 2020
This review sheds light on the use of aldehydes in the selective acylation of arene, heteroarene and alkyl (sp3, sp2and sp) C–H bonds by proficient utilization of the C–H activation strategy.
Kumar, Prashant, Dutta, Sriparna, Kumar, Sandeep, Bahadur, Vijay, van der Eycken, Erik V., Vimaleswaran, Karani Santhanarishnan, Parmar, Virinder S., Singh, Brajendra K.   +7 more
openaire   +4 more sources

Mechanisms and Inhibition of Porcupine-Mediated Wnt Acylation

Nature, 2022
Wnt signalling is essential for regulation of embryonic development and adult tissue homeostasis1–3, and aberrant Wnt signalling is frequently associated with cancers4.
Yang Liu, Xiaofeng Qi, Linda Donnelly, Nadia Elghobashi-Meinhardt, T. Long, Ri Zhou, Yingyuan Sun, Boyuan Wang, Xiaochun Li   +8 more
semanticscholar   +1 more source

Understanding the Function of Mammalian Sirtuins and Protein Lysine Acylation.

Annual Review of Biochemistry, 2021
Protein lysine acetylation is an important posttranslational modification that regulates numerous biological processes. Targeting lysine acetylation regulatory factors, such as acetyltransferases, deacetylases, and acetyl-lysine recognition domains, has ...
Miao Wang, Hening Lin
semanticscholar   +1 more source

Acylation of Anthocyanins and Their Applications in the Food Industry: Mechanisms and Recent Research Advances

Foods, 2022
Anthocyanins are extensively used as natural non-toxic compounds in the food industry due to their unique biological properties. However, the instability of anthocyanins greatly affects their industrial application.
Xiu-Er Luo, Ruoyong Wang, Jinhua Wang, Ying Li, Huainan Luo, Shi Chen, Xinan Zeng, Zhong Han   +7 more
semanticscholar   +1 more source