Results 1 to 10 of about 70,332 (311)
Usnic acid reduces colon cancer cell viability and colony formation by aff ecting cancer cell metabolism [PDF]
Kafkas Universitesi Veteriner Fakültesi Dergisi, 2022 Today, some natural and plant-based products are of great interest, at least as supplements, in cancer prevention and treatment due to their anti-cancer properties.
Turgut ANUK +7 more
doaj +1 more source
Human Sirtuin Regulators: The “Success” Stories
Frontiers in Physiology, 2021 The human sirtuins are a group of NAD+-dependent protein deacylases. They “erase” acyl modifications from lysine residues in various cellular targets including histones, transcription factors, and metabolic enzymes. Through these far-reaching activities,
Alyson M. Curry +4 more
doaj +1 more source
Lysine Fatty Acylation: Regulatory Enzymes, Research Tools, and Biological Function
Frontiers in Cell and Developmental Biology, 2021 Post-translational acylation of lysine side chains is a common mechanism of protein regulation. Modification by long-chain fatty acyl groups is an understudied form of lysine acylation that has gained increasing attention recently due to the ...
Garrison Komaniecki +4 more
doaj +1 more source
Biomedicines, 2022 Accumulating evidence has shown that sirtuin 7 (SIRT7), a mediator of various cellular activities, plays an important role in the pathogenesis of various immune-mediated inflammatory disorders.
Sanghyun Kim +13 more
doaj +1 more source
BZD9L1 Differentially Regulates Sirtuins in Liver-Derived Cells by Inducing Reactive Oxygen Species
Biomedicines, 2023 Growing evidence has highlighted that mitochondrial dysfunction contributes to drug-induced toxicities and leads to drug attrition and post-market withdrawals.
Yeuan Ting Lee +2 more
doaj +1 more source
Antioxidants, 2023 Stroke is one of the leading causes of morbidity and mortality worldwide. A main cause of brain damage by stroke is ischemia-reperfusion (IR) injury due to the increased production of reactive oxygen species (ROS) and energy failure caused by changes in ...
Vishal Chavda, Bingwei Lu
doaj +1 more source
The Emerging Role of SIRT7 in Glucose and Lipid Metabolism
Cells, 2023 Sirtuins (SIRT1–7 in mammals) are a family of NAD+-dependent lysine deacetylases and deacylases that regulate diverse biological processes, including metabolism, stress responses, and aging.
Kazuya Yamagata +2 more
doaj +1 more source
mSphere, 2022 Candida parapsilosis is an emerging fungal pathogen that primarily affects immunocompromised patients in hospitals. A significant risk factor is the use of implanted medical devices, which support the growth of biofilms composed of a mixture of ...
Christopher B. Rupert, Laura N. Rusche
doaj +1 more source
Sirtuin Modulators in Cellular and Animal Models of Human Diseases
Frontiers in Pharmacology, 2021 Sirtuins use NAD+ to remove various acyl groups from protein lysine residues. Through working on different substrate proteins, they display many biological functions, including regulation of cell proliferation, genome stability, metabolism, and cell ...
Jun Young Hong, Hening Lin, Hening Lin
doaj +1 more source
Sirtuins in Neuroendocrine Regulation and Neurological Diseases
Frontiers in Neuroscience, 2018 Silent information regulator 1 (SIRT1) is a mammalian homolog of the nicotinamide adenine dinucleotide (NAD)-dependent deacetylase sirtuin family. Sirtuin was originally studied as the lifespan-extending gene, silent information regulator 2 (SIRT2) in ...
Yuki Fujita +4 more
doaj +1 more source