Results 11 to 20 of about 45,770 (169)
PharmaceuticalsThe human sirtuins (SIRT1–SIRT7) are NAD+-dependent protein deacylases that orchestrate key cellular events such as metabolism, stress response, DNA repair, and aging. Accumulating evidence highlights their central role in women’s health.
Rasajna Madhusudhana +4 more
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Mitochondrial Sirtuins in Reproduction [PDF]
Antioxidants, 2021 Mitochondria act as hubs of numerous metabolic pathways. Mitochondrial dysfunctions contribute to altering the redox balance and predispose to aging and metabolic alterations. The sirtuin family is composed of seven members and three of them, SIRT3-5, are housed in mitochondria.
Di Emidio, Giovanna +5 more
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Sirtuin 1 and Sirtuin 3 in Granulosa Cell Tumors [PDF]
International Journal of Molecular Sciences, 2021 Sirtuins (SIRTs) are NAD+-dependent deacetylases that regulate proliferation and cell death. In the human ovary, granulosa cells express sirtuin 1 (SIRT1), which has also been detected in human tumors derived from granulosa cells, i.e., granulosa cell tumors (GCTs), and in KGN cells.
Nina Schmid +7 more
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Journal of Cell Science, 2011 Sirtuins are NAD-dependent deacetylases that are highly conserved from bacteria to human and SIR2 was originally shown to extend lifespan in budding yeast ([Imai et al., 2000][1]; [Kaeberlein et al., 1999][2]).
Takashi, Nakagawa, Leonard, Guarente
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Sirtuins: To Be or Not To Be in Diabetic Cardiomyopathy
Trends in Molecular Medicine, 2021 Diabetic cardiomyopathy is the leading cause of death among people with diabetes. Despite its severity and poor prognosis, there are currently no approved specific drugs to prevent or even treat diabetic cardiomyopathy. There is a need to understand the pathogenic mechanisms underlying the development of diabetic cardiomyopathy to design new ...
Palomer, Xavier +4 more
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Frontiers in Veterinary Science, 2023 Climate change is considered to be the primary cause of heat stress (HS) in broiler chickens. Owing to the unique properties of extracted polyphenols, resveratrol-loaded liposomal nanoparticles (Resv-Lipo NPs) were first explored to mitigate the harmful ...
Asmaa T. Y. Kishawy +13 more
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Pharmaceutical Biology, 2022 Context (-)-Epicatechin (EPI) is a crucial substance involved in the protective effects of flavanol-rich foods. Previous studies have indicated EPI has a cardioprotective effect, but the molecular mechanisms in inhibition of cardiac fibrosis are unclear ...
Yingchun Luo +6 more
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Sirtuins, Bioageing, and Cancer [PDF]
Journal of Aging Research, 2011 The Sirtuins are a family of orthologues of yeast Sir2 found in a wide range of organisms from bacteria to man. They display a high degree of conservation between species, in both sequence and function, indicative of their key biochemical roles. Sirtuins are heavily implicated in cell cycle, cell division, transcription regulation, and metabolism ...
McGuinness, D. +3 more
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Cell Reports, 2012 Controversy has recently arisen over the role of sirtuins in metazoan aging. In this issue of Cell Reports, Banerjee et al. demonstrate that Drosophila Sir2 is necessary for life span extension in response to dietary restriction and that its overexpression in the fat body increases the life span.
David Sinclair, Eric Verdin
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, 2011 Members of the sirtuin family including the founding protein Sir2 in Saccharomyces cerevisiae have been linked to lifespan extension in simple organisms. This finding prompted evaluation of the role of Sir2 orthologues in many aging-associated conditions including neurodegeneration, type II diabetes and cancer.
Sumit S, Mahajan +3 more
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