Results 11 to 20 of about 55,883 (307)

Sirtuin 1 and sirtuin 3: Physiological modulators of metabolism. [PDF]

Physiological Reviews, 2012
The sirtuins are a family of highly conserved NAD(+)-dependent deacetylases that act as cellular sensors to detect energy availability and modulate metabolic processes.
Banks, A.S., Horvath, T.L., Dietrich, M.O., Pfluger, P.T., Tschöp, M.H., Nogueiras, R., Chaudhary, N., Sinclair, D.A., Habegger, K.M., Finan, B.   +9 more
core   +3 more sources

Discovery and Validation of SIRT2 Inhibitors Based on Tenovin-6: Use of a 1H-NMR Method to Assess Deacetylase Activity [PDF]

Molecules, 2012
The search for potent and selective sirtuin inhibitors continues as chemical tools of this type are of use in helping to assign the function of this interesting class of deacetylases.
Nicholas J. Westwood, Sonia Lain, Tomas Lebl, Daumantas Matulis, Asta Zubrienė, Anna R. McCarthy, Louise L. Major, Vaida Morkūnaitė, Lisa Pirrie   +8 more
doaj   +2 more sources

Sirtuin Inhibitors Are Broadly Antiviral against Arboviruses

mBio, 2019
Arthropod-borne viruses are diverse pathogens and are often associated with human disease. These viruses span multiple genera, including flaviviruses, alphaviruses, and bunyaviruses. In a high-throughput drug screen, we found that tenovin-1 was antiviral
Brent A. Hackett, Mark Dittmar, Elisha Segrist, Nathan Pittenger, Julie To, Trevor Griesman, Beth Gordesky-Gold, David C. Schultz, Sara Cherry   +8 more
doaj   +2 more sources

Sirtuin 1 and endothelial glycocalyx [PDF]

, 2023
Sirtuin1 deficiency or reduced activity comprises one of the hallmarks of diseases as diverse as chronic cardiovascular, renal, and metabolic, some malignancies, and infections, as well as aging-associated diseases.
Song, Jong Wook, Song, Jong Wook; Department of Anesthesiology and Pain Medicine, Yonsei University College of Medicine, Seoul, South Korea, Goligorsky, Michael S, Lipphardt, Mark; Department of Nephrology and Rheumatology, Göttingen University Medical Center, Georg August University, Göttingen, Germany, Lipphardt, Mark, Goligorsky, Michael S; Renal Research Institute, New York Medical College at the Touro University, Valhalla, USA   +5 more
core   +3 more sources

Mitochondrial Sirtuins in Reproduction [PDF]

Antioxidants, 2021
Mitochondria act as hubs of numerous metabolic pathways. Mitochondrial dysfunctions contribute to altering the redox balance and predispose to aging and metabolic alterations. The sirtuin family is composed of seven members and three of them, SIRT3-5, are housed in mitochondria.
Di Emidio, Giovanna, Falone, Stefano, Artini, Paolo Giovanni, Amicarelli, Fernanda, D'Alessandro, Anna Maria, Tatone, Carla   +5 more
openaire   +5 more sources

Sirtuins in Women’s Health

Pharmaceuticals
The human sirtuins (SIRT1–SIRT7) are NAD+-dependent protein deacylases that orchestrate key cellular events such as metabolism, stress response, DNA repair, and aging. Accumulating evidence highlights their central role in women’s health.
Rasajna Madhusudhana, Abu Hamza, Emily Boyle, Shannon Pollock, Yana Cen   +4 more
doaj   +3 more sources

Sirtuins at a glance [PDF]

Journal of Cell Science, 2011
Sirtuins are NAD-dependent deacetylases that are highly conserved from bacteria to human and SIR2 was originally shown to extend lifespan in budding yeast ([Imai et al., 2000][1]; [Kaeberlein et al., 1999][2]).
Takashi, Nakagawa, Leonard, Guarente
openaire   +2 more sources

HaloTag-Targeted Sirtuin Rearranging Ligand (SirReal) for the Development of Proteolysis Targeting Chimeras (PROTACs) Against the Lysine Deacetylase Sirtuin 2 (Sirt2) [PDF]

, 2020
We have discovered the sirtuin rearranging ligands (SirReals) as a novel class of highly potent and selective inhibitors of the NAD+-dependent lysine deacetylase sirtuin 2 (Sirt2).
Sándor, Szunyogh, Dina, Robaa, Manfred, Jung, Attila, Lehotzky, Oliver, Einsle, Sören, Hammelmann, Nathalie, Wössner, Wolfgang, Sippl, Judit, Ovádi, Matthias, Schiedel, Judit, Oláh   +10 more
core   +2 more sources

Sirtuins: To Be or Not To Be in Diabetic Cardiomyopathy

Trends in Molecular Medicine, 2021
Diabetic cardiomyopathy is the leading cause of death among people with diabetes. Despite its severity and poor prognosis, there are currently no approved specific drugs to prevent or even treat diabetic cardiomyopathy. There is a need to understand the pathogenic mechanisms underlying the development of diabetic cardiomyopathy to design new ...
Palomer, Xavier, Aguilar-Recarte, David, García López, Raquel, Nistal Herrera, Juan Francisco, Vázquez-Carrera, Manuel   +4 more
openaire   +3 more sources

Sirtuins, Metabolism, and Cancer [PDF]

Frontiers in Pharmacology, 2012
More than a decade ago, sirtuins were discovered as a highly conserved family of NAD(+)-dependent enzymes that extend lifespan in lower organisms. In mammals, sirtuins are key regulators of stress responses and metabolism, influencing a range of diseases, including diabetes, neurodegeneration, and cancer. In recent years, new functions of sirtuins have
Martinez-Pastor, Barbara, Mostoslavsky, Raul   +1 more
openaire   +6 more sources