Results 31 to 40 of about 45,770 (169)
Microbial Cell, 2016 Increasing the stability or dynamics of the actin cytoskeleton can extend lifespan in C. elegans and S. cerevisiae. Actin cables of budding yeast, bundles of actin filaments that mediate cargo transport, affect lifespan control through effects on ...
Ryo Higuchi-Sanabria +4 more
doaj +1 more source
SIRT4 is an early regulator of branched-chain amino acid catabolism that promotes adipogenesis
Cell Reports, 2021 Summary: Upon nutrient stimulation, pre-adipocytes undergo differentiation to transform into mature adipocytes capable of storing nutrients as fat.
Elma Zaganjor +15 more
doaj +1 more source
Development of Second Generation Activity-Based Chemical Probes for Sirtuins
Molecules, 2020 NAD+ (nicotinamide adenine dinucleotide)-dependent protein deacylases, namely, the sirtuins, are important cell adaptor proteins that alter cell physiology in response to low calorie conditions.
Alyson M. Curry +4 more
doaj +1 more source
Opportunities and Difficulties in the Repurposing of HDAC Inhibitors as Antiparasitic Agents
Drugs and Drug CandidatesOngoing therapy for human parasite infections has a few known drugs but with serious side effects and the problem of drug resistance, impelling us to discover novel drug candidates with newer mechanisms of action.
Tapas Kumar Mohapatra +4 more
doaj +1 more source
Frontiers in Nutrition, 2022 Backgroundalpha-Mangostin, a polyphenolic xanthone, is primarily found in the pericarp of mangosteen throughout Southeast Asia and is considered as the “Queen of Fruit” in Thailand.
Waralee Ruankham +6 more
doaj +1 more source
Sirtuin as the target of anti-cancer therapy
Journal of Education, Health and Sport, 2020 Sirtuins is a group of nicotinamide dinucleotide (NAD +) - dependent, which have deacetylation and ADP-ribosylation activity. They work by detaching the acetyl group from the lysine residue of the histones, thanks to which they influence the control of ...
Marzena Baran +2 more
doaj +1 more source
Sirtuins and Insulin Resistance [PDF]
Frontiers in Endocrinology, 2018 The mammalian Sirtuins (SIRT1-7) are an evolutionarily conserved family of NAD+-dependent deacylase and mono-ADP-ribosyltransferase. Sirtuins display distinct subcellular localizations and functions and are involved in cell survival, senescence, metabolism and genome stability.
Shuang Zhou +2 more
openaire +3 more sources
A Selective Cyclic Peptidic Human SIRT5 Inhibitor
Molecules, 2016 In the current study, we discovered that a side chain-to-side chain cyclic pentapeptide harboring a central Nε-carboxyethyl-thiocarbamoyl-lysine residue behaved as a strong and selective (versus human SIRT1/2/3/6) inhibitor against human SIRT5-catalyzed ...
Jiajia Liu, Yajun Huang, Weiping Zheng
doaj +1 more source
Data in Brief, 2015 Expression of genes associated with inflammation was analyzed during differentiation of human pluripotent stem cells (PSCs) to hepatic cells. Messenger RNA transcript profiles of differentiated endoderm (day 5), hepatoblast (day 15) and hepatocyte-like ...
Joseph Ignatius Irudayam +10 more
doaj +1 more source
Frontiers in Bioengineering and Biotechnology, 2022 This study examined the role of sirtuins in the regenerative potential of articular chondrocytes. Sirtuins (SIRT1-7) play a key role in regulating cartilage homeostasis.
Hannah K. Heywood +6 more
doaj +1 more source