Results 31 to 40 of about 55,883 (307)

Discovery, in vivo activity, and mechanism of action of a small-molecule p53 activator [PDF]

, 2008
We have carried out a cell-based screen aimed at discovering small molecules that activate p53 and have the potential to decrease tumor growth. Here, we describe one of our hit compounds, tenovin-1, along with a more water-soluble analog, tenovin-6.
Campbell, Johanna, Murray, Karen E., Stark, Michael J.R., Lain, Sonia, Stark, Michael J. R., Baker, Lee, Appleyard, Virgina, Higgins, Maureen, Pass, Georgia, Mathers, Joanne, Lane, David P., Staples, Oliver D., Woods, Julie, McCarthy, Anna, Holland, Stephen J., Hollick, Jonathan J., Aoubala, Mustapha, Thompson, Alastair, Westwood, Nicholas J., Appleyard, Virginia   +19 more
core   +1 more source

Human Sirtuin 2 inhibitors, their mechanisms and binding modes - supplementary_material.docx

, 2023
 Figure S1. LigPlotPlus ligand binding diagrams for human Sirtuin 2 (hSIRT2) substrates.     Figure S2. LigPlotPlus ligand binding diagrams for human Sirtuin 2 (hSIRT2) reaction products.    Figure S3.
Andre Berndt Penteado (14766371), Gustavo Henrique Goulart Trossini (1385184), Haifa Hassanie (14766374), Renan Augusto Gomes (14293938), Flavio da Silva Emery (2917898)   +4 more
core   +1 more source

AIF1+CSF1R+ MSCs, induced by TNF‐α, act to generate an inflammatory microenvironment and promote hepatocarcinogenesis

Hepatology, EarlyView., 2022
Mesenchymal stem cells subset, educated by TNF‐α, are involved to generate inflammatory microenvironment and promote hepatocarcinogenesis Abstract Background and Aims Increasing evidence suggests that mesenchymal stem cells (MSCs) home to injured local tissues and the tumor microenvironment in the liver.
Chen Zong, Yan Meng, Fei Ye, Xue Yang, Rong Li, Jinghua Jiang, Qiudong Zhao, Lu Gao, Zhipeng Han, Lixin Wei   +9 more
wiley   +1 more source

Cardioprotective Effects of SIRT6 in a Mouse Model of Transverse Aortic Constriction-Induced Heart Failure

Frontiers in Physiology, 2017
SIRT6, a member of the NAD (+)-dependent class III deacetylase sirtuin family, plays important roles in the maintenance of cardiovascular homeostasis. Telomere shortening is a risk factor for age-associated diseases, including heart disease.
Yongming Li, Xianda Meng, Wenguang Wang, Fu Liu, Zhiru Hao, Yang Yang, Jinbo Zhao, Wensi Yin, Lijuan Xu, Ruiping Zhao, Ruiping Zhao, Jiang Hu   +11 more
doaj   +1 more source

RIPK3 dampens mitochondrial bioenergetics and lipid droplet dynamics in metabolic liver disease

Hepatology, EarlyView., 2022
RIPK3 dampens mitochondrial bioenergetics and lipid droplet dynamics in metabolic liver disease. Abstract Background and Aims Receptor‐interacting protein kinase 3 (RIPK3) mediates NAFLD progression, but its metabolic function is unclear. Here, we aimed to investigate the role of RIPK3 in modulating mitochondria function, coupled with lipid droplet (LD)
Marta B. Afonso, Tawhidul Islam, Julie Magusto, Ricardo Amorim, Véronique Lenoir, Rui F. Simões, José Teixeira, Liana C. Silva, Dominique Wendum, Isabelle Jéru, Corinne Vigouroux, Rui E. Castro, Paulo J. Oliveira, Carina Prip‐Buus, Vlad Ratziu, Jérémie Gautheron, Cecília M. P. Rodrigues   +16 more
wiley   +1 more source

Roles of sirtuins in asthma

Respiratory Research, 2022
AbstractSirtuins are nicotinamide adenine dinucleotide (NAD+)-dependent lysine deacylases and deacetylases that participate in a variety of cellular processes, including transcriptional activity, energy metabolism, DNA damage response, inflammation, apoptosis, autophagy, and oxidative stress.
Yahui Liu, Guochao Shi
openaire   +3 more sources

Nicotinamide riboside and pterostilbene reduces markers of hepatic inflammation in NAFLD: A double‐blind, placebo‐controlled clinical trial

Hepatology, EarlyView., 2022
NRPT 1X reduces ALT and ceramide 14:0 in 65% of subjects as compared to only 28% in the placebo group. Abstract Background and Aims The prevalence of NAFLD is increasing globally and on a path to becoming the most frequent cause of chronic liver disease. Strategies for the prevention and treatment of NAFLD are urgently needed.
Ryan W. Dellinger, Holly E. Holmes, Tina Hu‐Seliger, Rodney W. Butt, Stephen A. Harrison, Dariush Mozaffarian, Oliver Chen, Leonard Guarente   +7 more
wiley   +1 more source

Histone Deacetylase 1 and Sirtuin 1 Expression in Psoriatic Skin: A Comparison between Guttate and Plaque Psoriasis

Life, 2020
Abnormal histone modification by histone deacetylases (HDACs), including HDAC1 and sirtuin 1 (SIRT1), has been reported to play an important role in the pathogenesis of psoriasis by altering cell proliferation, differentiation, and inflammation. However,
Young-Ji Hwang, Jung-Im Na, Sang-Young Byun, Soon-Hyo Kwon, Seung-Hye Yang, Hyun-Sun Lee, Hye-Ryung Choi, Soyun Cho, Sang Woong Youn, Kyoung-Chan Park   +9 more
doaj   +1 more source

Integration of the Deacetylase SIRT1 in the Response to Nucleolar Stress: Metabolic Implications for Neurodegenerative Diseases

Frontiers in Molecular Neuroscience, 2019
Understanding underlying mechanisms of neurodegenerative diseases is fundamental to develop effective therapeutic intervention. Yet they remain largely elusive, but metabolic, and transcriptional dysregulation are common events.
Grzegorz Kreiner, Aynur Sönmez, Birgit Liss, Birgit Liss, Rosanna Parlato, Rosanna Parlato   +5 more
doaj   +1 more source

Sirtuin Control of Mitochondrial Dysfunction, Oxidative Stress, and Inflammation in Chagas Disease Models

Frontiers in Cellular and Infection Microbiology, 2021
Trypanosoma cruzi is a digenetic parasite that requires triatomines and mammalian host to complete its life cycle. T. cruzi replication in mammalian host induces immune-mediated cytotoxic proinflammatory reactions and cellular injuries, which are the ...
Xianxiu Wan, Nisha Jain Garg, Nisha Jain Garg   +2 more
doaj   +1 more source