Results 21 to 30 of about 45,770 (169)

Sirtuins, Metabolism, and Cancer [PDF]

Frontiers in Pharmacology, 2012
More than a decade ago, sirtuins were discovered as a highly conserved family of NAD(+)-dependent enzymes that extend lifespan in lower organisms. In mammals, sirtuins are key regulators of stress responses and metabolism, influencing a range of diseases, including diabetes, neurodegeneration, and cancer. In recent years, new functions of sirtuins have
Martinez-Pastor, Barbara, Mostoslavsky, Raul   +1 more
openaire   +6 more sources

SIRT6 regulates Ras-related protein R-Ras2 by lysine defatty-acylation

eLife, 2017
The Ras family of GTPases are important in cell signaling and frequently mutated in human tumors. Understanding their regulation is thus important for studying biology and human diseases.
Xiaoyu Zhang, Nicole A Spiegelman, Ornella D Nelson, Hui Jing, Hening Lin   +4 more
doaj   +1 more source

Cardioprotective Effects of SIRT6 in a Mouse Model of Transverse Aortic Constriction-Induced Heart Failure

Frontiers in Physiology, 2017
SIRT6, a member of the NAD (+)-dependent class III deacetylase sirtuin family, plays important roles in the maintenance of cardiovascular homeostasis. Telomere shortening is a risk factor for age-associated diseases, including heart disease.
Yongming Li, Xianda Meng, Wenguang Wang, Fu Liu, Zhiru Hao, Yang Yang, Jinbo Zhao, Wensi Yin, Lijuan Xu, Ruiping Zhao, Ruiping Zhao, Jiang Hu   +11 more
doaj   +1 more source

Roles of sirtuins in asthma

Respiratory Research, 2022
AbstractSirtuins are nicotinamide adenine dinucleotide (NAD+)-dependent lysine deacylases and deacetylases that participate in a variety of cellular processes, including transcriptional activity, energy metabolism, DNA damage response, inflammation, apoptosis, autophagy, and oxidative stress.
Yahui Liu, Guochao Shi
openaire   +3 more sources

Histone Deacetylase 1 and Sirtuin 1 Expression in Psoriatic Skin: A Comparison between Guttate and Plaque Psoriasis

Life, 2020
Abnormal histone modification by histone deacetylases (HDACs), including HDAC1 and sirtuin 1 (SIRT1), has been reported to play an important role in the pathogenesis of psoriasis by altering cell proliferation, differentiation, and inflammation. However,
Young-Ji Hwang, Jung-Im Na, Sang-Young Byun, Soon-Hyo Kwon, Seung-Hye Yang, Hyun-Sun Lee, Hye-Ryung Choi, Soyun Cho, Sang Woong Youn, Kyoung-Chan Park   +9 more
doaj   +1 more source

Sirtuin 1 and Sirtuin 3: Physiological Modulators of Metabolism [PDF]

Physiological Reviews, 2012
The sirtuins are a family of highly conserved NAD+-dependent deacetylases that act as cellular sensors to detect energy availability and modulate metabolic processes. Two sirtuins that are central to the control of metabolic processes are mammalian sirtuin 1 (SIRT1) and sirtuin 3 (SIRT3), which are localized to the nucleus and mitochondria ...
Ruben, Nogueiras, Kirk M, Habegger, Nilika, Chaudhary, Brian, Finan, Alexander S, Banks, Marcelo O, Dietrich, Tamas L, Horvath, David A, Sinclair, Paul T, Pfluger, Matthias H, Tschöp   +9 more
openaire   +2 more sources

Integration of the Deacetylase SIRT1 in the Response to Nucleolar Stress: Metabolic Implications for Neurodegenerative Diseases

Frontiers in Molecular Neuroscience, 2019
Understanding underlying mechanisms of neurodegenerative diseases is fundamental to develop effective therapeutic intervention. Yet they remain largely elusive, but metabolic, and transcriptional dysregulation are common events.
Grzegorz Kreiner, Aynur Sönmez, Birgit Liss, Birgit Liss, Rosanna Parlato, Rosanna Parlato   +5 more
doaj   +1 more source

Sirtuin Control of Mitochondrial Dysfunction, Oxidative Stress, and Inflammation in Chagas Disease Models

Frontiers in Cellular and Infection Microbiology, 2021
Trypanosoma cruzi is a digenetic parasite that requires triatomines and mammalian host to complete its life cycle. T. cruzi replication in mammalian host induces immune-mediated cytotoxic proinflammatory reactions and cellular injuries, which are the ...
Xianxiu Wan, Nisha Jain Garg, Nisha Jain Garg   +2 more
doaj   +1 more source

Retinal Aging and Sirtuins [PDF]

Ophthalmic Research, 2010
The process of aging involves the accumulating changes in the microenvironment that lead to cell senescence or apoptosis, and subsequent tissue or organ dysfunction. Multiple extrinsic and intrinsic events that cause DNA instability are associated with aging.
Yoko, Ozawa, Shunsuke, Kubota, Toshio, Narimatsu, Kenya, Yuki, Takashi, Koto, Mariko, Sasaki, Kazuo, Tsubota   +6 more
openaire   +2 more sources

Natural Products as Modulators of Sirtuins

Molecules, 2020
Natural products have been used for the treatment of human diseases since ancient history. Over time, due to the lack of precise tools and techniques for the separation, purification, and structural elucidation of active constituents in natural resources
Berin Karaman Mayack, Wolfgang Sippl, Fidele Ntie-Kang   +2 more
doaj   +1 more source