Results 41 to 50 of about 70,332 (311)
Cell, 2014 The mammalian sirtuins have emerged as critical regulators of cellular stress resistance, energy metabolism, and tumorigenesis. In some contexts, they delay the onset of age-related diseases and promote a healthy lifespan. The seven mammalian sirtuins, SIRT1-7, share a highly conserved NAD+-binding catalytic core domain although they exhibit distinct ...
Anderson, Kristin A. +4 more
openaire +2 more sources
Sirt1 expression is associated with CD31 expression in blood cells from patients with chronic obstructive pulmonary disease [PDF]
, 2016 Background: Cigarette smoke induced oxidative stress has been shown to reduce silent information regulator 1 (Sirt1) levels in lung tissue from smokers and patients with COPD patients.
Akai, Masaya +11 more
core +2 more sources
Retinal Aging and Sirtuins [PDF]
Ophthalmic Research, 2010 The process of aging involves the accumulating changes in the microenvironment that lead to cell senescence or apoptosis, and subsequent tissue or organ dysfunction. Multiple extrinsic and intrinsic events that cause DNA instability are associated with aging.
Yoko, Ozawa +6 more
openaire +2 more sources
Microbial Cell, 2016 Increasing the stability or dynamics of the actin cytoskeleton can extend lifespan in C. elegans and S. cerevisiae. Actin cables of budding yeast, bundles of actin filaments that mediate cargo transport, affect lifespan control through effects on ...
Ryo Higuchi-Sanabria +4 more
doaj +1 more source
Novel treatment strategies for chronic kidney disease: insights from the animal kingdom [PDF]
, 2018 Many of the >2 million animal species that inhabit Earth have developed survival mechanisms that aid in the prevention of obesity, kidney disease, starvation, dehydration and vascular ageing; however, some animals remain susceptible to these ...
Arnold, Walter +7 more
core +1 more source
Segmental aging underlies the development of a Parkinson phenotype in the AS/AGU rat [PDF]
, 2016 There is a paucity of information on the molecular biology of aging processes in the brain. We have used biomarkers of aging (SA β-Gal, p16Ink4a, Sirt5, Sirt6, and Sirt7) to demonstrate the presence of an accelerated aging phenotype across different ...
Khojah, Sohair M. +3 more
core +2 more sources
Sirtuin chemical mechanisms [PDF]
Biochimica et Biophysica Acta (BBA) - Proteins and Proteomics, 2010 Sirtuins are ancient proteins widely distributed in all lifeforms of earth. These proteins are universally able to bind NAD(+), and activate it to effect ADP-ribosylation of cellular nucleophiles. The most commonly observed sirtuin reaction is the ADP-ribosylation of acetyllysine, which leads to NAD(+)-dependent deacetylation.
openaire +2 more sources
SIRT4 is an early regulator of branched-chain amino acid catabolism that promotes adipogenesis
Cell Reports, 2021 Summary: Upon nutrient stimulation, pre-adipocytes undergo differentiation to transform into mature adipocytes capable of storing nutrients as fat.
Elma Zaganjor +15 more
doaj +1 more source
Development of Second Generation Activity-Based Chemical Probes for Sirtuins
Molecules, 2020 NAD+ (nicotinamide adenine dinucleotide)-dependent protein deacylases, namely, the sirtuins, are important cell adaptor proteins that alter cell physiology in response to low calorie conditions.
Alyson M. Curry +4 more
doaj +1 more source
Opportunities and Difficulties in the Repurposing of HDAC Inhibitors as Antiparasitic Agents
Drugs and Drug CandidatesOngoing therapy for human parasite infections has a few known drugs but with serious side effects and the problem of drug resistance, impelling us to discover novel drug candidates with newer mechanisms of action.
Tapas Kumar Mohapatra +4 more
doaj +1 more source