Results 41 to 50 of about 55,883 (307)
Retinal Aging and Sirtuins [PDF]
Ophthalmic Research, 2010 The process of aging involves the accumulating changes in the microenvironment that lead to cell senescence or apoptosis, and subsequent tissue or organ dysfunction. Multiple extrinsic and intrinsic events that cause DNA instability are associated with aging.
Yoko, Ozawa +6 more
openaire +2 more sources
Natural Products as Modulators of Sirtuins
Molecules, 2020 Natural products have been used for the treatment of human diseases since ancient history. Over time, due to the lack of precise tools and techniques for the separation, purification, and structural elucidation of active constituents in natural resources
Berin Karaman Mayack +2 more
doaj +1 more source
Sirtuin 1: A Dilemma in Transplantation
, 2020 Sirtuin 1, a member of sirtuin family of histone deacetylase enzymes, has been implicated in a variety of physiologic and pathologic events, including energy metabolism, cell survival, and age-related alterations.
Nuala Mooney +4 more
core +1 more source
Microbial Cell, 2016 Increasing the stability or dynamics of the actin cytoskeleton can extend lifespan in C. elegans and S. cerevisiae. Actin cables of budding yeast, bundles of actin filaments that mediate cargo transport, affect lifespan control through effects on ...
Ryo Higuchi-Sanabria +4 more
doaj +1 more source
SIRT4 is an early regulator of branched-chain amino acid catabolism that promotes adipogenesis
Cell Reports, 2021 Summary: Upon nutrient stimulation, pre-adipocytes undergo differentiation to transform into mature adipocytes capable of storing nutrients as fat.
Elma Zaganjor +15 more
doaj +1 more source
Development of Second Generation Activity-Based Chemical Probes for Sirtuins
Molecules, 2020 NAD+ (nicotinamide adenine dinucleotide)-dependent protein deacylases, namely, the sirtuins, are important cell adaptor proteins that alter cell physiology in response to low calorie conditions.
Alyson M. Curry +4 more
doaj +1 more source
The Relationship of Sirtuin 1 and Sirtuin 2 Expression with Clinicopathological Parameters in Non Small-Cell Lung Carcinomas [PDF]
Aim: Recent studies have shown that sirtuin signaling pathway activation could be a potential therapeutic target for future therapies and biomarkers for predicting prognosis in cancer. We aimed to investigate the association between Sirtuin 1 (SIRT1) and
Nagehan Barisik Ozdemir +3 more
core +1 more source
Sirtuins and Their Relevance to the Kidney [PDF]
Journal of the American Society of Nephrology, 2010 Sirtuins (silent information regulator 2 [Sir2] proteins) belong to an ancient family of evolutionary conserved nicotinamide adenine dinucleotide (NAD)(+)-dependent enzymes with deacetylase and/or mono-ADP-ribosyltransferase activity. They regulate DNA repair and recombination, chromosomal stability, and gene transcription, and most importantly mediate
Chuan-Ming, Hao, Volker H, Haase
openaire +2 more sources
Interaction of Klotho and sirtuins
Experimental Gerontology, 2023 In this article, we review the articles that have reported the interaction between Klotho and sirtuins.Sirtuins are a family of histone deacetylase enzymes that are considered to be the main regulators of biological processes. This family is one of the essential factors for postponing aging and increasing the life span of organisms.
Farzaneh Rostamzadeh +2 more
openaire +3 more sources
Opportunities and Difficulties in the Repurposing of HDAC Inhibitors as Antiparasitic Agents
Drugs and Drug CandidatesOngoing therapy for human parasite infections has a few known drugs but with serious side effects and the problem of drug resistance, impelling us to discover novel drug candidates with newer mechanisms of action.
Tapas Kumar Mohapatra +4 more
doaj +1 more source