Results 41 to 50 of about 45,770 (169)
Sirtuins in Epigenetic Regulation [PDF]
Chemical Reviews, 2015 1.1. Discovery of Sirtuins The founding member of sirtuin is the yeast-silencing information regulator 2 (SIR2) protein, one of four proteins (SIR1–4) required for silencing the mating-type information loci in yeast.1 SIR2–4, but not SIR1, are also required for gene silencing at telomeres.2 SIR2 also mediates gene silencing at the rDNA (rDNA) loci ...
Jing, Hui, Lin, Hening
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Drugs Targeting Sirtuin 2 Exhibit Broad-Spectrum Anti-Infective Activity
PharmaceuticalsDirect-acting anti-infective drugs target pathogen-coded gene products and are a highly successful therapeutic paradigm. However, they generally target a single pathogen or family of pathogens, and the targeted organisms can readily evolve resistance ...
Thomas Shenk +2 more
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Insights regarding sirtuin-dependent gene regulation during white koji production
Communicative & Integrative Biology, 2022 White koji, a solid-state culture of Aspergillus luchuensis mut. kawachii using grains such as rice and barley, is used as a source of amylolytic enzymes and citric acid for the production of shochu, a traditional Japanese distilled spirit. We previously
Taiki Futagami, Masatoshi Goto
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Sirtuin-mediated nuclear differentiation and programmed degradation in
BMC Cell Biology, 2011 Background The NAD+-dependent histone deacetylases, known as "sirtuins", participate in a variety of processes critical for single- and multi-cellular life.
Smith Joshua J +4 more
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Will Sirtuins Be Promising Therapeutic Targets for TBI and Associated Neurodegenerative Diseases?
Frontiers in Neuroscience, 2020 Traumatic brain injury (TBI), a leading cause of morbidity worldwide, induces mechanical, persistent structural, and metabolic abnormalities in neurons and other brain-resident cells.
Qianjie Yang +5 more
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Cells, 2022 Mitochondrial protein acetylation is associated with a host of diseases including cancer, Alzheimer’s, and metabolic syndrome. Deciphering the mechanisms regarding how protein acetylation contributes to disease pathologies remains difficult due to the ...
Courtney D. McGinnis +4 more
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Sirtuin Inhibitors Are Broadly Antiviral against Arboviruses
mBio, 2019 Arthropod-borne viruses are diverse pathogens and are often associated with human disease. These viruses span multiple genera, including flaviviruses, alphaviruses, and bunyaviruses. In a high-throughput drug screen, we found that tenovin-1 was antiviral
Brent A. Hackett +8 more
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NAD+ Homeostasis and Autophagy: Integrated Control Through Nutrient Signaling in Yeast and Mammals
CellsNicotinamide adenine dinucleotide (NAD+) is an essential metabolite facilitating redox and biochemical reactions in many cellular processes. Maintaining NAD+ homeostasis is critical for proper cellular function, and abnormalities in NAD+ metabolism have ...
Matilda McDaniel +2 more
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Frontiers in BioinformaticsBackgroundThe sirtuin (SIRT) family is an NAD+-dependent class III histone deacetylase protein that comprises seven members (SIRT1–7). SIRTs are involved in many cellular pathways, which enable them to act as significant regulators of critical diseases ...
Deepak Sharma, Rajiniraja Muniyan
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Elevated Serum SIRT 2 May Differentiate Parkinson’s Disease From Atypical Parkinsonian Syndromes
Frontiers in Molecular Neuroscience, 2019 Atypical Parkinson syndromes (APSs) often have symptoms that overlap with those of Parkinson’s disease (PD), especially early in the disease, making these disorders difficult to diagnose.
Amrendra Pratap Singh +7 more
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