Results 51 to 60 of about 55,883 (307)
Frontiers in Nutrition, 2022 Backgroundalpha-Mangostin, a polyphenolic xanthone, is primarily found in the pericarp of mangosteen throughout Southeast Asia and is considered as the “Queen of Fruit” in Thailand.
Waralee Ruankham +6 more
doaj +1 more source
, 2021 Breast feeding is regarded as the preferred nutrition modality for children during the first few months of life. It not only furthers growth and development but also is supposed to impact later life.
Kristina Hase +5 more
core +1 more source
Sirtuins: New Roles for Sirtuins in Aging and Disease [PDF]
Innovation in Aging, 2020 Abstract Sirtuins are NAD+-dependent enzymes related to yeast silent information regulator-2, a histone deacetylase that prevents premature aging through chromatin silencing. Mammalian sirtuins, SIRT1-SIRT7, have key functions that protect against diverse aging-related pathologic states, from cancer to metabolic and neurodegenerative ...
openaire +1 more source
Sirtuin as the target of anti-cancer therapy
Journal of Education, Health and Sport, 2020 Sirtuins is a group of nicotinamide dinucleotide (NAD +) - dependent, which have deacetylation and ADP-ribosylation activity. They work by detaching the acetyl group from the lysine residue of the histones, thanks to which they influence the control of ...
Marzena Baran +2 more
doaj +1 more source
Lipoic acid improves mitochondrial function in nonalcoholic steatosis through the stimulation of sirtuin 1 and sirtuin 3 [PDF]
, 2012 Nonalcoholic steatosis is an important hepatic complication of obesity linked to mitochondrial dysfunction and oxidative stress. Lipoic acid (LA) has been reported to have beneficial effects on mitochondrial function and to attenuate oxidative stress ...
Martínez, Jose A. [0000-0001-5218-6941] +10 more
core +1 more source
The roles of sirtuins in ferroptosis
Frontiers in Physiology, 2023 Ferroptosis represents a novel non-apoptotic form of regulated cell death that is driven by iron-dependent lipid peroxidation and plays vital roles in various diseases including cardiovascular diseases, neurodegenerative disorders and cancers. Plenty of iron metabolism-related proteins, regulators of lipid peroxidation, and oxidative stress-related ...
Jieqing Zeng +8 more
openaire +3 more sources
Chronobiology of Cancer: How Aging Fuels Oncogenesis at the Molecular Level
Aging and Cancer, EarlyView.This graphical abstract illustrates the key biological pathways linking aging with cancer development and progression. In the upper left, cumulative exposure to ultraviolet radiation, toxins, and reactive oxygen species (ROS) causes DNA damage and genomic instability, whereas age‐related decline in repair mechanisms, such as ATM/ATR, BER, and NER ...
Anu Singh, Aroonima Misra, Sufian Zaheer
wiley +1 more source
Putative involvement of sirtuin modulators in LPS-induced sickness behaviour in mice
, 2022 NAD(+)—dependent histone deacetylases (sirtuins 1–7) have been shown to be involved in various pathophysiological conditions including their involvement in cardiovascular, cancerous, neurodegenerative, immune dysregulation and inflammatory conditions ...
Kinra, Manas +11 more
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Advanced Healthcare Materials, EarlyView.Mitochondria‐targeted nanotherapies emerge as a promising strategy for combating aging‐associated neurodegenerative disorders (NDs) by restoring mitochondrial function, reducing oxidative stress, and improving neuronal survival. Recent advances in nanotechnology, therapeutic delivery, and translational research are highlighted, providing insights into ...
Dnyandev G. Gadhave +8 more
wiley +1 more source
Sirtuin modulators. Past, present, and future perspectives
, 2022 Sirtuins are NAD(+)-dependent protein lysine deacylase and mono-ADP ribosylases present in both prokaryotes and eukaryotes. The sirtuin family comprises seven isoforms in mammals, each possessing different subcellular localization and biological ...
D'Acunzo, Francesca +5 more
core +1 more source