Results 51 to 60 of about 45,770 (169)
Preconception resveratrol intake against infertility: Friend or foe?
Reproductive Medicine and Biology, 2020 Background Resveratrol is an antiaging, antioxidant, anti‐inflammatory, and insulin‐sensitizing natural polyphenolic compound. Growing evidence indicates that resveratrol has potential therapeutic effects in infertile women with diminished ovarian ...
Asako Ochiai, Keiji Kuroda
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Sirtuins, Aging, and Metabolism [PDF]
Cold Spring Harbor Symposia on Quantitative Biology, 2011 Sirtuins are nicotinamide adenine dinucleotide (NAD)-dependent protein deacetylases that link protein acetylation, metabolism, aging, and diseases of aging. Sirtuins were initially found to slow aging in lower organisms and more recently shown to mediate many effects of calorie restriction on metabolism and longevity in mammals. This chapter focuses on
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Sirtuins: New Roles for Sirtuins in Aging and Disease [PDF]
Innovation in Aging, 2020 Abstract Sirtuins are NAD+-dependent enzymes related to yeast silent information regulator-2, a histone deacetylase that prevents premature aging through chromatin silencing. Mammalian sirtuins, SIRT1-SIRT7, have key functions that protect against diverse aging-related pathologic states, from cancer to metabolic and neurodegenerative ...
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Molecules, 2012 The search for potent and selective sirtuin inhibitors continues as chemical tools of this type are of use in helping to assign the function of this interesting class of deacetylases.
Nicholas J. Westwood +8 more
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Molecules, 2018 Chromenone-derived natural products include chromones (flavone, isoflavone) and coumarins. Chromenone compounds not only exhibit impressive biological activities, but also are an important resource of experimentally used fluorophores, such as, 7-amino-4 ...
Hui Wen +6 more
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SIRTUINS, AGING AND DISEASE [PDF]
The FASEB Journal, 2010 SIR2 and related genes are NAD‐dependent deacetylases that slow aging in yeast, C. elegans , and Drosophila .
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LifeMetabolic dysfunction-associated steatotic liver disease (MASLD) is rapidly emerging as the most prevalent chronic liver disease, closely linked to the escalating rates of diabesity.
Zehuan Ding, Jian Zhang, Mahua Choudhury
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Assaying Chromatin Sirtuins [PDF]
, 2013 Most of the sirtuins' nuclear substrates identified so far are histones or other chromatin-associated proteins and, thus, it is of special relevance the development of good biochemical techniques to analyze the biology of these proteins in the context of chromatin.
Zhong, Lei +4 more
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Sirtuin chemical mechanisms [PDF]
Biochimica et Biophysica Acta (BBA) - Proteins and Proteomics, 2010 Sirtuins are ancient proteins widely distributed in all lifeforms of earth. These proteins are universally able to bind NAD(+), and activate it to effect ADP-ribosylation of cellular nucleophiles. The most commonly observed sirtuin reaction is the ADP-ribosylation of acetyllysine, which leads to NAD(+)-dependent deacetylation.
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MedicinaBackground and Objectives: The aim of this study was to investigate the changes in the SIRT family, the effects of sirtuins on kidney graft function, and their potential as biomarkers in patients who develop rejection after kidney transplantation ...
Necip Altundaş +8 more
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