Results 71 to 80 of about 45,770 (169)

X‐Box binding protein 1 downregulates SIRT6 to promote injury in pancreatic ductal epithelial cells

Immunity, Inflammation and Disease
Objective Acute pancreatitis (AP) stands as a frequent cause for clinical emergency hospital admissions. The X‐box binding protein 1 (XBP1) was found to be implicated in pancreatic acinar cell apoptosis.
Zhuo Yang, Shaojun Li, Chuan Zhao, Zongzheng Zhao, Juan Tan, Lu Zhang, Yuanqing Huang   +6 more
doaj   +1 more source

Unraveling the Role of AtSRT2 in Energy Metabolism, Stress Responses, and Gene Expression during Osmotic Stress in Arabidopsis thaliana

Plants
Sirtuins participate in chromatin remodeling and gene expression regulation during stress responses. They are the only deacetylases that couple the cellular NAD+-dependent energy metabolism with transcriptional regulation. They catalyze the production of
Alberto Obrecht, Manuel Paneque
doaj   +1 more source

Association of changes in expression of HDAC and SIRT genes after drug treatment with cancer cell line sensitivity to kinase inhibitors

Epigenetics
Histone deacetylases (HDACs) and sirtuins (SIRTs) are important epigenetic regulators of cancer pathways. There is a limited understanding of how transcriptional regulation of their genes is affected by chemotherapeutic agents, and how such ...
Julia Krushkal, Yingdong Zhao, Kyle Roney, Weimin Zhu, Alan Brooks, Deborah Wilsker, Ralph E. Parchment, Lisa M. McShane, James H. Doroshow   +8 more
doaj   +1 more source

Effects of Psyllium Husk on Metabolic Regulators, Insulin Resistance, and SIRT6 in Liver and Muscle of Type 2 Diabetic Rats. [PDF]

Vet Med Sci
Ümit F, Çiftci G, Onuk B, Aci R, Çaka Ö, Çiftci A.   +5 more
europepmc   +1 more source

The metabolic-epigenetic landscape of aging: interplay between histone acetylation, lactylation, and glycation. [PDF]

Front Aging
Bolgova O, Shypilova I, Mavrych V.
europepmc   +1 more source

Cross-Disorder Pruning-Plasticity-Aging Architecture in Substance Use Disorders and Anxiety: Transcriptome-Wide Association Insights and Mechanistic Synthesis. [PDF]

Cureus
Cheung N.
europepmc   +1 more source

Evaluation of Molecular Responses and Longevity Markers in <i>Acheta domesticus</i> Following Combined Resveratrol and Nanodiamond Exposure. [PDF]

Int J Mol Sci
Ziętara-Krzyk P, Flasz B, Augustyniak M.   +2 more
europepmc   +1 more source

Dapagliflozin Protects Cardiomyocytes against Doxorubicin-Induced Toxicity by Modulating Sirtuin 1/Sirtuin 3 and Ferroptosis Pathway. [PDF]

ACS Pharmacol Transl Sci
Khine HEE, Mangmool S, Parichatikanond W.   +2 more
europepmc   +1 more source

Correction: Exercise and the hepatic sirtuin network: rethinking the research focus on SIRT1, SIRT3, and SIRT6. [PDF]

Front Physiol
Kwon JW.
europepmc   +1 more source

[Retracted] Ultrasound‑targeted microbubble destruction‑mediated overexpression of Sirtuin 3 inhibits the progression of ovarian cancer. [PDF]

Oncol Rep
Cheng L, Zhang D, Yan W.
europepmc   +1 more source