Results 71 to 80 of about 55,883 (307)

Rhoifolin Alleviates Ulcerative Colitis by Targeting NMNAT1 and Activating SIRT1‐FOXO1 Signaling to Enhance ILC3s Effector Function

Advanced Science, EarlyView.
Rhoifolin directly targets NMNAT1, thereby activating nicotinamide salvage pathway and promoting intracellular NAD+ biosynthesis. Elevated NAD+ levels enhance SIRT1 activity, leading to FOXO1 deacetylation and nuclear translocation. Nuclear FOXO1 subsequently binds to the IL‐22 promoter, upregulating IL‐22 transcription and potentiating ILC3 effector ...
Hongqiong Yang, Yishu Zhang, Sijia Feng, Xiaoqing Ma, Jiayi Feng, Junwei Wang, Jialin Gao, An Pan, Dapeng Wu, Kang Ding, Caijuan Zheng, Qi Lv, Lihong Hu   +12 more
wiley   +1 more source

Modulation of sirtuins during monolayer chondrocyte culture influences cartilage regeneration upon transfer to a 3D culture environment

Frontiers in Bioengineering and Biotechnology, 2022
This study examined the role of sirtuins in the regenerative potential of articular chondrocytes. Sirtuins (SIRT1-7) play a key role in regulating cartilage homeostasis.
Hannah K. Heywood, Stephen D. Thorpe, Stephen D. Thorpe, Stephen D. Thorpe, Renos M. Jeropoulos, Paul W. Caton, David A. Lee   +6 more
doaj   +1 more source

Role of Sirtuin 1 in metabolic regulation

, 2010
Sirtuin proteins are an evolutionarily conserved family of NAD(+)-dependent protein deacetylases. Originally discovered in yeast as gene-silencing proteins, they subsequently emerged as key regulators of life span in yeast and other lower species. Recent
Silva, Jose P, Claes Wahlestedt, Wahlestedt, Claes, Jose P. Silva   +3 more
core   +1 more source

Fibrillarin Resists Cellular Senescence Via SIRT1‐Dependent Nicotinamide Metabolism and Its Inhibition Sensitizes Senolytic Therapy in Esophageal Squamous Cell Carcinoma

Advanced Science, EarlyView.
FBL directly binds to and stabilizes SIRT1 by blocking its ubiquitin‐proteasome degradation, thereby sustaining nicotinamide metabolism and redox homeostasis to counteract cellular senescence in ESCC. Genetic and pharmacological suppression of FBL sensitizes tumor cells to senolytic therapy.
Xing Jin, Hong Liu, Ling Gao, Lei Liu, Ji‐Bin Liu, Xiaoxia Jin, Ming‐Song Wang, Dan Liu, Li Feng, Wen‐Lian Chen   +9 more
wiley   +1 more source

Drugs Targeting Sirtuin 2 Exhibit Broad-Spectrum Anti-Infective Activity

Pharmaceuticals
Direct-acting anti-infective drugs target pathogen-coded gene products and are a highly successful therapeutic paradigm. However, they generally target a single pathogen or family of pathogens, and the targeted organisms can readily evolve resistance ...
Thomas Shenk, John L. Kulp III, Lillian W. Chiang   +2 more
doaj   +1 more source

Insights regarding sirtuin-dependent gene regulation during white koji production

Communicative & Integrative Biology, 2022
White koji, a solid-state culture of Aspergillus luchuensis mut. kawachii using grains such as rice and barley, is used as a source of amylolytic enzymes and citric acid for the production of shochu, a traditional Japanese distilled spirit. We previously
Taiki Futagami, Masatoshi Goto
doaj   +1 more source

Sirtuin deacetylases in neurodegenerative diseases of aging

, 2013
Sirtuin enzymes are a family of highly conserved protein deacetylases that depend on nicotinamide adenine dinucleotide (NAD+) for their activity. There are seven sirtuins in mammals and these proteins have been linked with caloric restriction and aging ...
Guarente, Leonard Pershing, Leonard Guarente, Herskovits, A. Zara, Adrianna Z Herskovits   +3 more
core   +1 more source

DDX3x Regulates NINJ1 Transcription via Histone Lactylation in Sepsis Associated‐Acute Kidney Injury

Advanced Science, EarlyView.
This study identifies a potential therapeutic approach for sepsis‐associated acute kidney injury (SA‐AKI). We found that during SA‐AKI, reduced expression of DDX3x in renal tubular epithelial cells mediates histone delactylation, which in turn upregulates NINJ1 transcription and triggers tubular cell death. Conversely, Odetiglucan confers protection by
Hongyu Liang, Jihong Jiang, Huanxin Yin, Chunyan Liu, Hongjun Huang, Yan Luo, Minmin Zhu, Qiuyun Wang   +7 more
wiley   +1 more source

Sirtuin-mediated nuclear differentiation and programmed degradation in Tetrahymena

BMC Cell Biology, 2011
Background The NAD+-dependent histone deacetylases, known as "sirtuins", participate in a variety of processes critical for single- and multi-cellular life.
Smith Joshua J, Cottrell Kyle A, Freggiaro Sydney, Slade Kristin M, Wiley Emily A   +4 more
doaj   +1 more source

Sirtuin 1 Levels in Recurrent Implantation Failure

, 2017
Sirtuin 1 has an important role in cellular processes, including apoptosis and cellular stress. The purpose of this study was to assess serum sirtuin 1 levels in women with recurrent implantation failure (RIF).
Ozgu-Erdinc, A.S., Ayla Aktulay, Caglayan, E.K., Salim Erkaya, Sarikaya, E., A. Ozgu-Erdinc, Aktulay, Ayla, Kiyak Caglayan, Emel, Erkaya, Salim, Yilmaz, N., Gulerman, C., Ozgu-Erdinc, A Seval, Yaprak Engin-Ustun, Gulerman, Cavidan, Emel Kiyak Caglayan, Erkaya, S., Engin-Ustun, Y., Cavidan Gulerman, Esma Sarikaya, Nafiye Yilmaz, Sarikaya, Esma, Aktulay, A., Engin-Ustun, Yaprak, Demirtas, Canan, Yilmaz, Nafiye, Canan Demirtas, Demirtas, C.   +26 more
core   +1 more source