Results 1 to 10 of about 9,186 (133)

Aspirin-Derived Salicyl-CoA Drives Histone Lysine Salicylation Regulated by CBP and SIRT2. [PDF]

Adv Sci (Weinh)
Aspirin‐derived salicyl‐CoA serves as a previously unrecognized acyl donor for protein lysine salicylation. This study identifies histone lysine salicylation as a reversible epigenetic modification regulated by CBP and SIRT2, expanding the biochemical actions of aspirin beyond its canonical acetylation‐dependent mechanisms and providing a new framework
Zhang F, Zhou C, He J, Huang P, Zhang R, Hu H, Jiao M, Hu L, Liu F, Qi X, He X, Yang Y, Chinn YE, Feng D, Zhang D, Zhang Q.   +15 more
europepmc   +2 more sources

Hypoxia/lactate orchestrates the reprogramming metabolism of lung adenocarcinoma by modulating the SIRT2-mediated acetylation [PDF]

Journal of Translational Medicine
Background Silent information regulator 2 (SIRT2) has been described to have dual roles as an oncogene and tumor suppressor gene in non-small cell lung cancer, but its functional selection and the precise mechanisms of its action remain to be elucidated.
Jie Tao, Zhan-yi Chen, Jing-na Xun, Meixiang Wang, Juan-xi Liu, Ying Zhang, Douglas B. Lowrie, Yao Li, Xiao-yong Fan   +8 more
doaj   +2 more sources

SIRT2-mediated deacetylation activates USP22 catalytic function for PD-L1 protein stabilization and tumor immune escape [PDF]

The Journal of Clinical Investigation
Immune checkpoint blockade (ICB), including PD-1/PD-L1 inhibitors, has transformed cancer therapy but benefits only a subset of patients. Understanding how PD-L1 is regulated and identifying strategies to overcome resistance remain critical.
Na Li, Qiong Gao, Huijun Jia, Guoqing Xue, Yuanzhang Zhou, Shengnan Wang, Suxian Ma, Bingjin Hu, Zhuoyue Zhao, Chen Su, Yinghong Liu, Wenxuan Xi, Zhonghao Li, Donna D. Zhang, Peng Chu, Zhaolin Sun, Deyu Fang   +16 more
doaj   +2 more sources

SIRT2 Alleviates Chronic Cold Stress-Induced Lung Injury by Regulating Lung Macrophage M1 Polarization [PDF]

Current Issues in Molecular Biology
SIRT2 (Sirtuin 2) is an NAD+-dependent deacetylase that exerts crucial regulatory effects on immune homeostasis and macrophage activation. While chronic cold exposure is a known predisposing factor for pulmonary dysfunction, the precise mechanisms by ...
Bin Xu, Shizhen Lu, Rongge Xia, Qi Han, Zhiqi Zhu, Xinpeng Chen, Huiying Shi, Wencong Wu, Wanqun Xing, Jingjing Lu   +9 more
doaj   +2 more sources

Sirtuin 2 inhibits global protein synthesis via Rheb-GTPase degradation [PDF]

EMBO Reports
Increased global protein synthesis is associated with the development and progression of several aging-related diseases and disorders. Strategies like calorie restriction and pharmacological inhibition of protein synthesis have exhibited health-promoting
Amarjeet Shrama, Yanlin Zi, Anwit Shriniwas Pandit, Kirtika Jha, Vikrant Kumar Sinha, Dimple Nagesh, Bhoomika Shivanaiah, Venkatraman Ravi, Souvik Ghosh, Danish Khan, Arathi Bangalore Prabhashankar, Thoniparambil Sunil Sumi, Satish Rajpurohit, Sunayana Ningaraju, Sukanya Raghu, Anand Srivastava, Mahavir Singh, Hening Lin, Nagalingam R Sundaresan   +18 more
doaj   +2 more sources

Dihydroartemisinin exerts antitumour activity by blocking SIRT2-IGFBP1-induced PI3K/AKT/mTOR signal transduction in liver cancer [PDF]

Scientific Reports
The human NAD (+)-dependent deacetylase silent information regulator isoform 2 (SIRT2) is the cytoplasm-localized member of the sirtuin family, which has received increasing attention for its potential roles in cancer diagnosis and therapy.
Zhengbin Chai, Jingwen Liu, Jing Liu, Linfei Niu, Xiaoqing Wang, Chunyan Liu, Fabin Han   +6 more
doaj   +2 more sources

Usnic acid reduces colon cancer cell viability and colony formation by aff ecting cancer cell metabolism [PDF]

Kafkas Universitesi Veteriner Fakültesi Dergisi, 2022
Today, some natural and plant-based products are of great interest, at least as supplements, in cancer prevention and treatment due to their anti-cancer properties.
Turgut ANUK, Barış YILDIZ, Ramazan DEMİREL, Meryem İÇEN, Selma YILDIRIM, Hatice BEŞEREN, Baycan MOR, Özkan ÖZDEN   +7 more
doaj   +1 more source

Sirt2-associated transcriptome modifications in cisplatin-induced neuronal injury

BMC Genomics, 2020
Background Chemotherapy-induced peripheral neuropathy is not only one of the most common causes of dose reduction or discontinuation of cancer treatment, but it can also permanently decrease the quality of life of cancer patients and survivors.
Xin Zhao, Wuying Du, Manchao Zhang, Zainab O. Atiq, Fen Xia   +4 more
doaj   +1 more source

SIRT2 gene has a classic SRE element, is a downstream target of serum response factor and is likely activated during serum stimulation. [PDF]

PLoS ONE, 2017
The sirtuin proteins are an evolutionarily conserved family of NAD+-dependent deacetylases that regulate various cellular functions. Among the seven sirtuins, SIRT2 is predominantly found in the cytoplasm, and is present in a wide range of tissues ...
Xiaomin Zhang, Gohar Azhar, Jeanne Y Wei
doaj   +1 more source

Multiple Roles of SIRT2 in Regulating Physiological and Pathological Signal Transduction

Genetics Research, 2022
Sirtuin 2 (SIRT2), as a member of the sirtuin family, has representative features of evolutionarily highly conserved nicotinamide adenine dinucleotide (NAD+)-dependent deacetylase activity. In addition, SIRT2, as the only sirtuin protein colocalized with
Changhui Zhu, Xue Dong, Xiwei Wang, Yingying Zheng, Juanjuan Qiu, Yanling Peng, Jiajun Xu, Zhengbin Chai, Chunyan Liu   +8 more
doaj   +1 more source