Results 1 to 10 of about 10,461 (217)

The Clinical Significance of SIRT2 in Malignancies: A Tumor Suppressor or an Oncogene?

Frontiers in Oncology, 2020
Sirtuin 2 (SIRT2) is a member of the sirtuin protein family. It is a Class III histone deacetylase (HDACs) and predominantly localized to the cytosol. SIRT2 deacetylates histones and a number of non-histone proteins and plays a pivotal role in various ...
Ren Xiubao
exaly   +3 more sources

Sirtuin 2 inhibits global protein synthesis via Rheb-GTPase degradation [PDF]

EMBO Reports
Increased global protein synthesis is associated with the development and progression of several aging-related diseases and disorders. Strategies like calorie restriction and pharmacological inhibition of protein synthesis have exhibited health-promoting
Amarjeet Shrama, Yanlin Zi, Anwit Shriniwas Pandit, Kirtika Jha, Vikrant Kumar Sinha, Dimple Nagesh, Bhoomika Shivanaiah, Venkatraman Ravi, Souvik Ghosh, Danish Khan, Arathi Bangalore Prabhashankar, Thoniparambil Sunil Sumi, Satish Rajpurohit, Sunayana Ningaraju, Sukanya Raghu, Anand Srivastava, Mahavir Singh, Hening Lin, Nagalingam R Sundaresan   +18 more
doaj   +2 more sources

SIRT2 Alleviates Chronic Cold Stress-Induced Lung Injury by Regulating Lung Macrophage M1 Polarization [PDF]

Current Issues in Molecular Biology
SIRT2 (Sirtuin 2) is an NAD+-dependent deacetylase that exerts crucial regulatory effects on immune homeostasis and macrophage activation. While chronic cold exposure is a known predisposing factor for pulmonary dysfunction, the precise mechanisms by ...
Bin Xu, Shizhen Lu, Rongge Xia, Qi Han, Zhiqi Zhu, Xinpeng Chen, Huiying Shi, Wencong Wu, Wanqun Xing, Jingjing Lu   +9 more
doaj   +2 more sources

Dihydroartemisinin exerts antitumour activity by blocking SIRT2-IGFBP1-induced PI3K/AKT/mTOR signal transduction in liver cancer [PDF]

Scientific Reports
The human NAD (+)-dependent deacetylase silent information regulator isoform 2 (SIRT2) is the cytoplasm-localized member of the sirtuin family, which has received increasing attention for its potential roles in cancer diagnosis and therapy.
Zhengbin Chai, Jingwen Liu, Jing Liu, Linfei Niu, Xiaoqing Wang, Chunyan Liu, Fabin Han   +6 more
doaj   +2 more sources

Elucidating the role of SIRT2 in hepatocellular carcinoma through multi-omics and deep learning [PDF]

Discover Oncology
Background Hepatocellular carcinoma (HCC) is a prevalent global malignancy characterized by a high incidence and poor prognosis. Current diagnostic and therapeutic modalities are insufficient to meet the demands for effective HCC diagnosis and management.
Changan Chen, Tingmei Yang, Caiyuan Yu, Lijiao Cui, Bingjun Cai, Zhenkai Li, Shicai Ye, Yijie Weng   +7 more
doaj   +2 more sources

Usnic acid reduces colon cancer cell viability and colony formation by aff ecting cancer cell metabolism [PDF]

Kafkas Universitesi Veteriner Fakültesi Dergisi, 2022
Today, some natural and plant-based products are of great interest, at least as supplements, in cancer prevention and treatment due to their anti-cancer properties.
Turgut ANUK, Barış YILDIZ, Ramazan DEMİREL, Meryem İÇEN, Selma YILDIRIM, Hatice BEŞEREN, Baycan MOR, Özkan ÖZDEN   +7 more
doaj   +1 more source

SIRT2 gene has a classic SRE element, is a downstream target of serum response factor and is likely activated during serum stimulation. [PDF]

PLoS ONE, 2017
The sirtuin proteins are an evolutionarily conserved family of NAD+-dependent deacetylases that regulate various cellular functions. Among the seven sirtuins, SIRT2 is predominantly found in the cytoplasm, and is present in a wide range of tissues ...
Xiaomin Zhang, Gohar Azhar, Jeanne Y Wei
doaj   +1 more source

Sirt2-associated transcriptome modifications in cisplatin-induced neuronal injury

BMC Genomics, 2020
Background Chemotherapy-induced peripheral neuropathy is not only one of the most common causes of dose reduction or discontinuation of cancer treatment, but it can also permanently decrease the quality of life of cancer patients and survivors.
Xin Zhao, Wuying Du, Manchao Zhang, Zainab O. Atiq, Fen Xia   +4 more
doaj   +1 more source

Multiple Roles of SIRT2 in Regulating Physiological and Pathological Signal Transduction

Genetics Research, 2022
Sirtuin 2 (SIRT2), as a member of the sirtuin family, has representative features of evolutionarily highly conserved nicotinamide adenine dinucleotide (NAD+)-dependent deacetylase activity. In addition, SIRT2, as the only sirtuin protein colocalized with
Changhui Zhu, Xue Dong, Xiwei Wang, Yingying Zheng, Juanjuan Qiu, Yanling Peng, Jiajun Xu, Zhengbin Chai, Chunyan Liu   +8 more
doaj   +1 more source

Discovery of Selective SIRT2 Inhibitors as Therapeutic Agents in B-Cell Lymphoma and Other Malignancies

Molecules, 2020
Genetic ablation as well as pharmacological inhibition of sirtuin 2 (SIRT2), an NAD+-dependent protein deacylase, have therapeutic effects in various cancers and neurodegenerative diseases.
Sarwat Chowdhury, Smitha Sripathy, Alyssa A. Webster, Angela Park, Uyen Lao, Joanne H. Hsu, Taylor Loe, Antonio Bedalov, Julian A. Simon   +8 more
doaj   +1 more source