SIRT1 and SIRT2 Modulators: Potential Anti-Inflammatory Treatment for Depression? [PDF]
, 2021 Depression is a psychiatric disorder that has a significant health burden on patients and their families. Unfortunately, the current antidepressant medications that mainly target monoamine neurotransmitters have limited efficacy.
Shailendra Anoopkumar-Dukie +5 more
core +1 more source
Development of a NanoBRET assay to validate inhibitors of Sirt2-mediated lysine deacetylation and defatty-acylation that block prostate cancer cell migration [PDF]
, 2022 Sirtuin2 (Sirt2) with its NAD+-dependent deacetylase and defatty-acylase activities plays a central role in the regulation of specific cellular functions.
Olaf, Groß +18 more
core +1 more source
SIRT1 and SIRT2 modulators reduce LPS-induced inflammation in HAPI microglial cells and protect SH-SY5Y neuronal cells in vitro [PDF]
, 2021 Neuroinflammation is associated with the development of depression. Deacetylases SIRT1 and SIRT2 are reported to exert neuroprotective effects in aging, neurogenesis, neurodegeneration and neuroinflammation. Therefore, this study aimed to investigate the
Mallik, SB +3 more
core +1 more source
Is SIRT2 required for necroptosis? [PDF]
Nature, 2014 Sirtuins can promote deacetylation of a wide range of substrates in diverse cellular compartments and regulate many cellular processes¹,². Recently Narayan et al., reported that SIRT2 was required for necroptosis based on their findings that SIRT2 inhibition, knock-down or knock-out prevented necroptosis.
Newton K +17 more
openaire +3 more sources
Development of First-in-Class Dual Sirt2/HDAC6 Inhibitors as Molecular Tools for Dual Inhibition of Tubulin Deacetylation [PDF]
, 2023 Dysregulation of both tubulin deacetylases sirtuin 2 (Sirt2) and the histone deacetylase 6 (HDAC6) has been associated with the pathogenesis of cancer and neurodegeneration, thus making these two enzymes promising targets for pharmaceutical intervention.
Olaf, Groß +23 more
core +1 more source
SIRT2- and NRF2-Targeting Thiazole-Containing Compound with Therapeutic Activity in Huntington's Disease Models [PDF]
, 2016 There are currently no disease-modifying therapies for the neurodegenerative disorder Huntington's disease (HD). This study identified novel thiazole-containing inhibitors of the deacetylase sirtuin-2 (SIRT2) with neuroprotective activity in ex vivo ...
H Runne (7752554) +23 more
core +4 more sources
Discovery and validation of SIRT2 inhibitors based on tenovin-6 : use of a 1H-NMR method to assess deacetylase activity [PDF]
, 2012 The search for potent and selective sirtuin inhibitors continues as chemical tools of this type are of use in helping to assign the function of this interesting class of deacetylases.
Pirrie, L +26 more
core +1 more source
Role of microglial SIRT2 on neuroinflammation [PDF]
, 2023 reservedSirtuin 2 (SIRT2) has been associated with aging, age-related pathologies and neuroinflammation. In the present study, we have analyzed in mice the implication of microglial sirtuin 2 in two different models of neuroinflammation: an acute pro ...
CUCCHIARA, ESTER
core
SIRT2 inhibition rescues neurodegenerative pathology but increases systemic inflammation in a transgenic mouse model of alzheimer’s disease [PDF]
, 2023 Sirtuin 2 (SIRT2) has been proposed to have a central role on aging, inflammation, cancer and neurodegenerative diseases; however, its specific function remains controversial.
Expósito, S. (Sara) +15 more
core +2 more sources
Expression of SIRT2 and SIRT6 in Retinoblastoma
Ophthalmic Research, 2015 <b><i>Purpose:</i></b> SIRT2 and SIRT6 are members of the sirtuin family and are associated with cancer development and progression in certain tumours, but their expression in retinoblastoma has not been studied. The primary objective of our study was to determine the expression of SIRT2 and SIRT6 in human retinoblastoma cases. &
Maria Eugenia Orellana +5 more
openaire +2 more sources