Results 31 to 40 of about 11,198 (208)
Cell Death and Disease, 2022 Osteosarcomas (OS) are highly metastatic and usually lead to poor outcomes. Epithelial-mesenchymal transition (EMT) is reported to be a critical event in metastasis. SIRT2 exerts dual functions in many different tumors.
Yonghao Tian +5 more
doaj +1 more source
SIRT1 and SIRT2 Modulators: Potential Anti-Inflammatory Treatment for Depression?
, 2021 Depression is a psychiatric disorder that has a significant health burden on patients and their families. Unfortunately, the current antidepressant medications that mainly target monoamine neurotransmitters have limited efficacy.
Shailendra Anoopkumar-Dukie +5 more
core +1 more source
Interphase nucleo-cytoplasmic shuttling and localization of SIRT2 during mitosis. [PDF]
PLoS ONE, 2007 The human NAD+-dependent protein deacetylase SIRT2 resides predominantly in the cytoplasm where it functions as a tubulin deacetylase. Here we report that SIRT2 maintains a largely cytoplasmic localization during interphase by active nuclear export in a ...
Brian J North, Eric Verdin
doaj +1 more source
SIRT2 mediated downregulation of FOXM1 in response to TGFβ through the RAF-MEK-ERK signaling pathway in colon cancer [PDF]
Archives of Biological Sciences, 2021 The transcription factor forkhead box M1 (FOXM1) is frequently upregulated in many solid tumors, including those in the colon. As a master regulator, the sirtuin (SIRT) protein family is comprised of seven nicotinamide adenine dinucleotide (NAD ...
Ozden Ozkan, Park Seong-Hoon
doaj +1 more source
SIRT2, tubulin deacetylation, and oligodendroglia differentiation [PDF]
Cell Motility, 2007 AbstractThe mammalian silent information regulator 2 (SIRT2) is an NAD‐dependent histone deacetylase with known roles in the regulation of the cell cycle. SIRT2 is also a tubulin deacetylase functioning as an early mitotic checkpoint, but its roles in regulating cytoplasmic microtubule dynamics were unknown.
Bor Luen, Tang, Christelle En Lin, Chua
openaire +2 more sources
Development of First-in-Class Dual Sirt2/HDAC6 Inhibitors as Molecular Tools for Dual Inhibition of Tubulin Deacetylation [PDF]
, 2023 Dysregulation of both tubulin deacetylases sirtuin 2 (Sirt2) and the histone deacetylase 6 (HDAC6) has been associated with the pathogenesis of cancer and neurodegeneration, thus making these two enzymes promising targets for pharmaceutical intervention.
Olaf, Groß +23 more
core +2 more sources
Technology in Cancer Research & Treatment, 2020 Objective: The present study aimed to explore the function of sirtuin 2 (SIRT2) on cell proliferation, apoptosis, rat sarcoma virus (RAS)/ extracellular signal-regulated kinase (ERK) pathway in endometrial cancer (EC).
Yanjuan Guo MD +4 more
doaj +1 more source
Inhibition of SIRT2 suppresses hepatic fibrosis [PDF]
American Journal of Physiology-Gastrointestinal and Liver Physiology, 2016 Liver fibrosis can progress to cirrhosis and result in serious complications of liver disease. The pathogenesis of liver fibrosis involves the activation of hepatic stellate cells (HSCs), the underlying mechanisms of which are not fully known. Emerging evidence suggests that the classic histone deacetylases play a role in liver fibrosis, but the role ...
Maribel, Arteaga +9 more
openaire +2 more sources
SIRT1 and SIRT2 Activity Control in Neurodegenerative Diseases [PDF]
Frontiers in Pharmacology, 2021 Sirtuins are NAD+ dependent histone deacetylases (HDAC) that play a pivotal role in neuroprotection and cellular senescence. SIRT1-7 are different homologs from sirtuins. They play a prominent role in many aspects of physiology and regulate crucial proteins.
Ramu Manjula +3 more
openaire +3 more sources
npj Parkinson's Disease, 2022 NAD-dependent protein deacetylase Sirtuin 2 (SIRT2), which regulates several cellular pathways by deacetylating multiple substrates, has been extensively studied in the context of Parkinson’s disease (PD). Although several studies based on the MPTP model
Jianguo Yan +9 more
doaj +1 more source