Results 51 to 60 of about 10,461 (217)
Inhibition of SIRT2 suppresses hepatic fibrosis [PDF]
American Journal of Physiology-Gastrointestinal and Liver Physiology, 2016 Liver fibrosis can progress to cirrhosis and result in serious complications of liver disease. The pathogenesis of liver fibrosis involves the activation of hepatic stellate cells (HSCs), the underlying mechanisms of which are not fully known. Emerging evidence suggests that the classic histone deacetylases play a role in liver fibrosis, but the role ...
Maribel, Arteaga +9 more
openaire +2 more sources
SIRT1 and SIRT2 Activity Control in Neurodegenerative Diseases [PDF]
Frontiers in Pharmacology, 2021 Sirtuins are NAD+ dependent histone deacetylases (HDAC) that play a pivotal role in neuroprotection and cellular senescence. SIRT1-7 are different homologs from sirtuins. They play a prominent role in many aspects of physiology and regulate crucial proteins.
Ramu Manjula +3 more
openaire +3 more sources
Review of the anti-inflammatory effect of SIRT1 and SIRT2 modulators on neurodegenerative diseases [PDF]
, 2020 Neurodegenerative disease refers to a range of chronic and progressive disorders that are characterized by dysfunction and loss of neurons. Neurodegeneration involves protein misfolding, oxidative injury, impaired mitochondrial function, neurotrophin ...
Zhang, Yuqing +3 more
core +1 more source
SIRT2 Contributes to the Regulation of Intestinal Cell Proliferation and DifferentiationSummary
Cellular and Molecular Gastroenterology and Hepatology, 2020 Background and Aims: Intestinal mucosa undergoes a continual process of proliferation, differentiation, and apoptosis. Disruption of this homeostasis is associated with disorders such as inflammatory bowel disease (IBD).
Chang Li +8 more
doaj +1 more source
Scientific Reports, 2021 Sirtuin 2 (Sirt2) nicotinamide adenine dinucleotide-dependent deacetylase enzyme has been reported to alter diverse biological functions in the cells and onset of diseases, including cancer, aging, and neurodegenerative diseases, which implicate the ...
Shiv Bharadwaj +5 more
doaj +1 more source
The FASEB Journal, 2018 In our everyday lives, we are constantly being exposed to DNA damaging agents, both from internal and external sources. The most deleterious type of DNA damage a cell can suffer is the DNA double‐stranded break (DSB). Breast Cancer 1 (BRCA1) is a protein necessary for the proper repair of resultant DNA DSBs through the homologous ...
Elizabeth Minten +4 more
openaire +1 more source
The SIRT2 Deacetylase Regulates Autoacetylation of p300 [PDF]
Molecular Cell, 2008 Autoacetylation of the p300 histone acetyltransferase controls the transition between VP16-mediated chromatin acetylation and preinitiation complex (PIC) assembly. Currently, it is unknown if and how autoacetylated p300 is deacetylated. We found that the NAD(+)-dependent histone deacetylase SIRT2 deacetylates p300 in vitro and in cells.
Black, Joshua C. +4 more
openaire +2 more sources
Inhibition of Sirt2 Alleviates Fibroblasts Activation and Pulmonary Fibrosis via Smad2/3 Pathway
Frontiers in Pharmacology, 2021 Idiopathic pulmonary fibrosis (IPF) is a fatal disease with unknown cause and limited treatment options. Its mechanism needs to be further explored. Sirtuin2 (Sirt2), a nicotinamide adenine dinucleotide (NAD)-dependent deacetylase, has been proved to be ...
Hui Gong +5 more
doaj +1 more source
Tubulin deacetylation assay with SIRT2. [PDF]
, 2015 (A) GST-SIRT2 wild-type (wt) or a C-terminally truncated GST-SIRT2-ΔCT fusion proteins were incubated with commercially available purified tubulin in the presence of NAD+ for the indicated periods of time (0 to 90 minutes). GST was included as a negative
Patricia Verheugd (800551) +5 more
core +1 more source
SIRT2 as a Therapeutic Target for Age-Related Disorders [PDF]
Frontiers in Pharmacology, 2012 Sirtuin proteins are conserved regulators of aging that have recently emerged as important modifiers of several diseases which commonly occur later in life such as cancer, diabetes, cardiovascular, and neurodegenerative diseases. In mammals, there are seven sirtuins (SIRT1-7), which display diversity in subcellular localization and function.
RIta eMachado de Oliveira +6 more
openaire +5 more sources