Results 51 to 60 of about 11,198 (208)
, 2021 Neuroinflammation is associated with the development of depression. Deacetylases SIRT1 and SIRT2 are reported to exert neuroprotective effects in aging, neurogenesis, neurodegeneration and neuroinflammation. Therefore, this study aimed to investigate the
Mallik, SB +3 more
core +1 more source
The FASEB Journal, 2018 In our everyday lives, we are constantly being exposed to DNA damaging agents, both from internal and external sources. The most deleterious type of DNA damage a cell can suffer is the DNA double‐stranded break (DSB). Breast Cancer 1 (BRCA1) is a protein necessary for the proper repair of resultant DNA DSBs through the homologous ...
Elizabeth Minten +4 more
openaire +1 more source
Scientific Reports, 2021 Sirtuin 2 (Sirt2) nicotinamide adenine dinucleotide-dependent deacetylase enzyme has been reported to alter diverse biological functions in the cells and onset of diseases, including cancer, aging, and neurodegenerative diseases, which implicate the ...
Shiv Bharadwaj +5 more
doaj +1 more source
Role of microglial SIRT2 on neuroinflammation
, 2023 reservedSirtuin 2 (SIRT2) has been associated with aging, age-related pathologies and neuroinflammation. In the present study, we have analyzed in mice the implication of microglial sirtuin 2 in two different models of neuroinflammation: an acute pro ...
CUCCHIARA, ESTER
core
SIRT2 as a Therapeutic Target for Age-Related Disorders [PDF]
Frontiers in Pharmacology, 2012 Sirtuin proteins are conserved regulators of aging that have recently emerged as important modifiers of several diseases which commonly occur later in life such as cancer, diabetes, cardiovascular, and neurodegenerative diseases. In mammals, there are seven sirtuins (SIRT1-7), which display diversity in subcellular localization and function.
RIta eMachado de Oliveira +6 more
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Inhibition of Sirt2 Alleviates Fibroblasts Activation and Pulmonary Fibrosis via Smad2/3 Pathway
Frontiers in Pharmacology, 2021 Idiopathic pulmonary fibrosis (IPF) is a fatal disease with unknown cause and limited treatment options. Its mechanism needs to be further explored. Sirtuin2 (Sirt2), a nicotinamide adenine dinucleotide (NAD)-dependent deacetylase, has been proved to be ...
Hui Gong +5 more
doaj +1 more source
SIRT1 and SIRT2: emerging targets in neurodegeneration
EMBO Molecular Medicine, 2013 Abstract Sirtuins are NAD‐dependent protein deacetylases known to have protective effects against age‐related diseases such as cancer, diabetes, cardiovascular and neurodegenerative diseases. In mammals, there are seven sirtuins (SIRT1‐7), which display diversity in subcellular localization and function.
Donmez G, Outeiro TF
openaire +5 more sources
The SIRT2 Deacetylase Stabilizes Slug to Control Malignancy of Basal-like Breast Cancer
Cell Reports, 2016 Summary: Overabundance of Slug protein is common in human cancer and represents an important determinant underlying the aggressiveness of basal-like breast cancer (BLBC).
Wenhui Zhou +6 more
doaj +1 more source
Modulation Of Microtubule Acetylation By The Interplay Of TPPP/p25, SIRT2 And New Anticancer Agents With Anti-SIRT2 Potency [PDF]
Scientific Reports, 2017 AbstractThe microtubule network exerts multifarious functions controlled by its decoration with various proteins and post-translational modifications. The disordered microtubule associated Tubulin Polymerization Promoting Protein (TPPP/p25) and the NAD+-dependent tubulin deacetylase sirtuin-2 (SIRT2) play key roles in oligodendrocyte differentiation by
Szabó, Adél +9 more
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Effects of Dimerization on the Deacylase Activities of Human SIRT2
Biochemistry, 2023 Human sirtuin isoform 2 (SIRT2) is an NAD+-dependent enzyme that functions as a lysine deacetylase and defatty-acylase. Here, we report that SIRT2 readily dimerizes in solution and in cells and that dimerization affects its ability to remove different acyl modifications from substrates.
Jie Yang +2 more
openaire +3 more sources