Results 61 to 70 of about 10,461 (217)
The SIRT2 Deacetylase Stabilizes Slug to Control Malignancy of Basal-like Breast Cancer
Cell Reports, 2016 Summary: Overabundance of Slug protein is common in human cancer and represents an important determinant underlying the aggressiveness of basal-like breast cancer (BLBC).
Wenhui Zhou +6 more
doaj +1 more source
Activation of GSK3β by Sirt2 is required for early lineage commitment of mouse embryonic stem cell. [PDF]
PLoS ONE, 2013 Sirt2, a member of the NAD(+)-dependent protein deacetylase family, is increasingly recognized as a critical regulator of the cell cycle, cellular necrosis and cytoskeleton organization.
Xiaoxing Si +6 more
doaj +1 more source
Image_1_Inhibition of SIRT2 by Targeting GSK3β-Mediated Phosphorylation Alleviates SIRT2 Toxicity in SH-SY5Y Cells.JPEG [PDF]
, 2019 Sirtuin 2 (SIRT2) is thought to be important in the pathogenesis of Parkinson’s disease (PD), and the inhibition of SIRT2 rescues α-synuclein toxicity in a cellular model of PD.
Xuemin Wang (337948) +5 more
core +1 more source
THE STRESS RESPONSE ROLE OF SIRT2 IN CANCER AND IMMUNOLOGY [PDF]
, 2020 150 pagesSIRT2 is one of the mammalian NAD+-dependent lysine deacylase. It has attracted growing research interest due to the broad deacylation substrate scope and diverse cellular functions.
Wang, Miao
core +1 more source
SIRT2 promotes murine melanoma progression through natural killer cell inhibition
Scientific Reports, 2021 SIRT2, an NAD+-dependent histone deacetylase, has been shown to play a pivotal role in various physiological processes, however, its role in cancer is currently controversial.
Manchao Zhang +8 more
doaj +1 more source
Modulation Of Microtubule Acetylation By The Interplay Of TPPP/p25, SIRT2 And New Anticancer Agents With Anti-SIRT2 Potency [PDF]
Scientific Reports, 2017 AbstractThe microtubule network exerts multifarious functions controlled by its decoration with various proteins and post-translational modifications. The disordered microtubule associated Tubulin Polymerization Promoting Protein (TPPP/p25) and the NAD+-dependent tubulin deacetylase sirtuin-2 (SIRT2) play key roles in oligodendrocyte differentiation by
Szabó, Adél +9 more
openaire +3 more sources
Structural features of SIRT2. [PDF]
, 2015 (A) Primary sequences of SIRT2 isoform 1 (SIRT2-iso1) and isoform 2 (SIRT2-iso2) aligned with that of Hst2 from S. cerevisiae (obtained using the BLAST webserver (http://blast.ncbi.nlm.nih.gov/Blast.cgi)).
Patricia Verheugd (800551) +5 more
core +1 more source
PLoS Pathogens, 2018 Salmonella being a successful pathogen, employs a plethora of immune evasion mechanisms. This contributes to pathogenesis, persistence and also limits the efficacy of available treatment.
Mayuri Gogoi +5 more
doaj +1 more source
Aging Is a Key Driver for Adult Acute Myeloid Leukemia
Aging and Cancer, EarlyView.Acute myeloid leukemia (AML) is a classical age‐related hematologic malignancy, and a key driver of AML is aging, which profoundly regulates intrinsic factors such as genomic instability, epigenetic reprogramming, and metabolic dysregulation, and alters bone marrow microenvironment.
Rong Yin, Haojian Zhang
wiley +1 more source
Advanced Science, EarlyView.METTL3‐mediated m6A modification stabilizes KDR/Kdr mRNA through YTHDC2, amplifying the VEGFA‐KDR feedback loop and disturbing Th17/Treg balance. This pathway promotes persistent inflammation and tissue damage in patients with AIT, and inhibiting the METTL3‐KDR axis effectively disrupts this circuit, alleviating thyroid tissue injury and disease ...
Qingyi Hu +7 more
wiley +1 more source