DLST Succinylation-Mediated Mitochondrial Metabolic Remodeling and Cuproptosis Resistance Promote Malignant Progression of Lung Adenocarcinoma. [PDF]
Adv Sci (Weinh)The DLST K409 succinylation mediated by CPT1A promotes OXPHOS and redox homeostasis through regulating enzyme activity, thereby promoting the malignant progression of LUAD. Notably, the succinylation of DLST can enhance the cuproptosis resistance by inhibiting its lipoylation.
Li X +9 more
europepmc +3 more sources
Biochemical Analysis of Histone Succinylation [PDF]
Biochemistry Research International, 2017 Posttranslational modification (PTM) of proteins is used to regulate protein activity and stability. Histone PTMs are regarded as some of the most important, as they can directly regulate gene expression through chromatin reorganization.
Atsushi Yokoyama +2 more
doaj +5 more sources
The dawn of succinylation: a posttranslational modification [PDF]
American Journal of Physiology - Cell Physiology, 2018 Posttranslational modifications affect almost all proteins and are critical to a well-functioning and diverse proteome; however, many modifications remain relatively unknown and unstudied. This paper will give a perspective on the rapidly developing, novel posttranslational modification called succinylation.
Narasaiah Kolliputi +2 more
exaly +4 more sources
A Novel tRNA Half mt-5'-tiRNA-Tyr Promotes Colorectal Cancer Proliferation via Inducing HARS2 Succinylation. [PDF]
Adv Sci (Weinh)A mitochondria‐derived tRNA half, mt‐5’‐tiRNA‐Tyr, is upregulated in colorectal cancer tissues and plasma and promotes tumor proliferation. It binds HARS2 and promotes CPT1A‐associated HARS2 K91 succinylation, disrupts HARS2–mt‐tRNA‐His association, impairs mitochondrial translation, enhances succinate‐linked metabolic reprogramming, and shows promise ...
Gu X +10 more
europepmc +2 more sources
Lysine succinylation, the metabolic bridge between cancer and immunity
Genes and Diseases, 2023 Lysine succinylation is a naturally occurring post-translational modification (PTM) that regulates the stability and function of proteins. It can be regulated by enzymes such as SIRT5 and SIRT7.
Shuye Lin, Teng Ma, Hongyun Ruan
exaly +3 more sources
SIRT7‐Mediated H2BK120 Succinylation Drives Aberrant Mitophagy in Sepsis‐Associated Cognitive Dysfunction [PDF]
Advanced scienceSepsis triggers hippocampal SIRT7 loss, promoting histone H2B succinylation and activation of the PD‐1/PD‐L1–PINK1 axis. This metabolic‐epigenetic cascade drives aberrant mitophagy and neuronal injury, ultimately causing cognitive deficits. Targeting SIRT7‐dependent succinylation offers a potential strategy to protect brain function during sepsis ...
Meng N +12 more
europepmc +2 more sources
CPT1A through succinylation regulates the CTCF/LINC01503‒91aa feedback loop to promote gemcitabine resistance in pancreatic ductal adenocarcinoma. [PDF]
Clin Transl MedLINC01503 encoded a 91‐amino acid protein named 1503‒91aa, which enhanced carnitine palmitoyl transferase 1A (CPT1A) activity and regulated fatty acid oxidation (FAO) by competitively binding to malonyl‐CoA. Meanwhile, we found a positive feedback loop whereby CPT1A acts as a succinyltransferase to stabilise CTCF (a transcription factor driving ...
Fang DL +8 more
europepmc +2 more sources
A succinylation‐based classifier predicts chemotherapy response in prostate cancer and reveals KAT2A as a therapeutic target [PDF]
Clinical and Translational MedicineBackground Chemotherapy resistance remains a critical hurdle in advanced prostate cancer (PCa). Succinylation, an essential post‐translational modification linking cellular metabolism with epigenetic regulation, has been implicated in tumour progression;
Antao Dong +6 more
doaj +2 more sources
KAT2A Promotes the Progression of Renal Cell Carcinoma by Regulating the Succinylation of SERPINE2. [PDF]
Kaohsiung J Med SciABSTRACT Epithelial‐mesenchymal transition (EMT) and angiogenesis are critical drivers of renal cell carcinoma (RCC) progression, yet their upstream regulatory mechanisms remain incompletely understood. This study aimed to investigate the role of KAT2A in RCC and elucidate the underlying molecular mechanism by which it promotes tumor progression.
Liu CC, Li XD.
europepmc +2 more sources
Stage-Specific H3K14 and H3K23 Succinylation Orchestrates Insect Metamorphosis and Oogenesis. [PDF]
Adv Sci (Weinh)Stage‐specific succinylation of histone H3 at lysine 14 and 23 differentially controls insect metamorphosis and oogenesis through distinct GPCR‐PKC signaling cascades, revealing an evolutionarily conserved epigenetic mechanism that coordinates key life‐history traits.
Jing YP +9 more
europepmc +2 more sources