Results 21 to 30 of about 6,092 (196)

MDCAN-Lys: A Model for Predicting Succinylation Sites Based on Multilane Dense Convolutional Attention Network

Biomolecules, 2021
Lysine succinylation is an important post-translational modification, whose abnormalities are closely related to the occurrence and development of many diseases.
Huiqing Wang, Hong Zhao, Zhiliang Yan, Jian Zhao, Jiale Han   +4 more
doaj   +2 more sources

Regulators of Cancer Progression: Succinylation

Cancers
Lysine succinylation is a recently discovered post-translational protein modification, the process of which requires the participation of various enzymes. The close association between cancer and protein post-translational modifications (PTMs), such as acetylation and phosphorylation, has been extensively investigated and well-established.
Jie Gao, Wei Yu
openaire   +3 more sources

A systematic identification of species-specific protein succinylation sites using joint element features information

International Journal of Nanomedicine, 2017
Md Mehedi Hasan,1 Mst Shamima Khatun,2 Md Nurul Haque Mollah,2 Cao Yong,3 Dianjing Guo1 1School of Life Sciences and the State Key Laboratory of Agrobiotechnology, The Chinese University of Hong Kong, Shatin, New Territory, Hong Kong, People’s ...
Hasan MM, Khatun MS, Mollah MNH, Yong C, Guo D   +4 more
doaj   +1 more source

The role and therapeutic potential of succinate and succinylation in cardiovascular diseases [PDF]

Clinical Epigenetics
Cardiovascular diseases (CVDs) are the leading cause of global mortality and disease burden, with pathogenesis involving metabolic remodelling and inflammatory responses.
Wenyan Liu, Yu Han, Fengquan Zhang, Shuai Leng, Wenqian Yu   +4 more
doaj   +2 more sources

G3BP1 Succinylation at K413 is Critical for Cardiac Function by Modulating PI3K-AKT-mTOR Signal Axis. [PDF]

Adv Sci (Weinh)
Schematic illustrating the impact of G3BP1 succinylation at K413 on cardiac function. In the healthy human heart, G3BP1 succinylation maintains homeostatic mTOR signaling. In patients with dilated cardiomyopathy (DCM) and heart failure (HF), G3BP1 de‐succinylation induces RagA expression and disrupts the binding of the TSC1/2 complex, leading to the ...
Zhang Y, Yao C, Chen Y, Cai K, Lu Z, Wu B, Yu K, Shi Y, Zhao J, Zhou X.   +9 more
europepmc   +2 more sources

Altered succinylation of mitochondrial proteins, APP and tau in Alzheimer’s disease [PDF]

Nature Communications, 2022
Succinylation is a metabolism-associated post-translational protein modification. Here the authors describe changes to the succinylation of proteins in the brain of individuals with Alzheimer’s disease.
Yun Yang, Victor Tapias, Diana Acosta, Hui Xu, Huanlian Chen, Ruchika Bhawal, Elizabeth T. Anderson, Elena Ivanova, Hening Lin, Botir T. Sagdullaev, Jianer Chen, William L. Klein, Kirsten L. Viola, Sam Gandy, Vahram Haroutunian, M. Flint Beal, David Eliezer, Sheng Zhang, Gary E. Gibson   +18 more
doaj   +2 more sources

The metabolic-epigenetic interface: lysine succinylation orchestrates bidirectional crosstalk in neurodegenerative disorders [PDF]

Frontiers in Neurology
Succinylation, a nexus between metabolism and epigenetic regulation, is a central factor in the onset and progression of neurodegenerative diseases (NDDs).
Fanglei Chai, Chong Liu, Yandong Liu, Wei Zou   +3 more
doaj   +2 more sources

Detecting Succinylation sites from protein sequences using ensemble support vector machine

BMC Bioinformatics, 2018
Background Lysine succinylation is a new kind of post-translational modification which plays a key role in protein conformation regulation and cellular function control. To understand the mechanism of succinylation profoundly, it is necessary to identify
Qiao Ning, Xiaosa Zhao, Lingling Bao, Zhiqiang Ma, Xiaowei Zhao   +4 more
doaj   +2 more sources

Cholangiocarcinoma PDHA1 succinylation suppresses macrophage antigen presentation via alpha-ketoglutaric acid accumulation

Nature Communications
Gemcitabine combined with cisplatin is the first-line chemotherapy for advanced cholangiocarcinoma, but drug resistance remains a challenge, leading to unsatisfactory therapeutic effect.
Ning Zhang, Linmao Sun, Shuo Zhou, Changyong Ji, Tianming Cui, Qi Chu, Jiareng Ye, Shuhang Liang, Kun Ma, Yufeng Liu, Xianying Li, Xinyu Guo, Weizhi Zhang, Xuetian Gu, Cheng Cheng, Qingrui Zha, Shengwei Tao, Yunguang Zhang, Junhui Chu, Chenghui Wu, Yuchen Zhang, Jiabei Wang, Yao Liu, Lianxin Liu   +23 more
doaj   +2 more sources

SUCLG1 deficiency-induced histone succinylation impairs oncogene expression in acute myeloid leukemia

Cell Reports
Summary: Mitochondria-driven histone lysine succinylation is emerging as a critical signaling system that links cellular metabolism to the pathogenesis of diseases, including cancer. Here, we report that a global increase in protein/histone succinylation
Mengqing Gao, Minhui Shi, Hao Ding, Lei Xu, Na Zhao, Li Wang, Shujuan Huang, Hui Jiang, Ekaterina Bourova-Flin, Jianqing Mi, Saadi Khochbin, Domenico Iuso, Xiaoyu Zhu   +12 more
doaj   +2 more sources